Effects of exercise in normobaric hypoxia on hemodynamics during muscle metaboreflex activation in normoxia

Mulliri, Gabriele; Sainas, Gianmarco; Magnani, Sara; Roberto, Silvana; Ghiani, Giovanna; Mannoni, Mauro; Pinna, Virginia; Willis, Sarah J.; Millet, Grégoire P.; Doneddu, Azzurra; Crisafulli, Antonio

doi:10.1007/s00421-019-04103-y

Cited by 11 publications

(19 citation statements)

References 53 publications

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“…Subjects were blinded about the actual content of oxygen they were breathing, which was constantly checked by an operator by means of oxygen analyser provided with the device (Maxtec, Handi+, Salt Lake City, UT, USA). A similar experimental setting was already employed in our lab in a recent investigation (Mulliri et al 2019 ).…”

Section: Methodsmentioning

confidence: 99%

“…In a recent paper from our lab, Mulliri et al ( 2019 ) showed the effect on central hemodynamics of a hypoxic dynamic exercise sessions at two different levels of fraction of inspired oxygen (13.5% and 15.5% of FiO 2 ) during a subsequent PEMI protocol conducted in normoxia. Authors found a reduction in the responses of SV and ventricular filling rate (VFR; a measure of venous return/ventricular diastolic function) after hypoxic exercise.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, further studies are needed to better understand the physiological and hemodynamic changes that occur when a hypoxic stimulus is applied during exercise. Specifically, considering that the few studies which dealt with the consequences of hypoxia on the cardiovascular regulation took into account only few variables (blood pressure and HR) (Gujic et al 2007 ; Houssiere et al 2005 ) or were conducted after exercise in hypoxia (Mulliri et al 2019 ), it should be advisable to conduct a study which takes into account all the hemodynamic modulators (pre-load, inotropism, after-load, chronotropism) during hypoxic exercise. This would help in better clarify the effect of hypoxic exercise on the cardiovascular reflexes and regulation.…”

Section: Introductionmentioning

confidence: 99%

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A brief bout of exercise in hypoxia reduces ventricular filling rate and stroke volume response during muscle metaboreflex activation

et al. 2020

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Purpose The hemodynamic consequences of exercise in hypoxia have not been completely investigated. The present investigation aimed at studying the hemodynamic effects of contemporary normobaric hypoxia and metaboreflex activation. Methods Eleven physically active, healthy males (age 32.7 ± 7.2 years) completed a cardiopulmonary test on an electromagnetically braked cycle-ergometer to determine their maximum workload (W max). On separate days, participants performed two randomly assigned exercise sessions (3 minutes pedalling at 30% of W max): (1) one in normoxia (NORMO), and (2) one in normobaric hypoxia with FiO 2 set to 13.5% (HYPO). After each session, the following protocol was randomly assigned: either (1) post-exercise muscle ischemia (PEMI) to study the metaboreflex, or (2) a control exercise recovery session, i.e., without metaboreflex activation. Hemodynamics were assessed with impedance cardiography. Results The main result was that the HYPO session impaired the ventricular filling rate (measured as stroke volume/diastolic time) response during PEMI versus control condition in comparison to the NORMO test (31.33 ± 68.03 vs. 81.52 ± 49 .23 ml•s −1 ,respectively, p = 0.003). This caused a reduction in the stroke volume response (1.45 ± 9.49 vs. 10.68 ± 8.21 ml, p = 0.020). As a consequence, cardiac output response was impaired during the HYPO test. Conclusions The present investigation suggests that a brief exercise bout in hypoxia is capable of impairing cardiac filling rate as well as stroke volume during the metaboreflex. These results are in good accordance with recent findings showing that among hemodynamic modulators, ventricular filling is the most sensible variable to hypoxic stimuli.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A brief bout of exercise in hypoxia reduces ventricular filling rate and stroke volume response during muscle metaboreflex activation

et al. 2020

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“…In addition, even though our model did not allow the three-way statistical analysis, from Figure 3 it can be observed a difference between ethnic groups: Nepalese porters may have required a higher blood flow increment after exercise in altitude, both in the forearm and in the thigh muscle. The marked hemodynamic response to submaximal dynamic exercise, as found in the present study, might be further characterized in terms of hemodynamic reserves (Bassareo and Crisafulli, 2020): hypoxia has a role in muscle metaboreflex (Mulliri et al, 2019), and the dynamics of diverse muscle groups can be stressed to achieve further insight. This response might be the result of systemic advantage, achieved by heritable factors or due to long-term adaptation, representing a likely basis for a further adaptation in exercised muscles.…”

Section: Discussionmentioning

confidence: 63%

Muscle Oxygen Delivery in the Forearm and in the Vastus Lateralis Muscles in Response to Resistance Exercise: A Comparison Between Nepalese Porters and Italian Trekkers

et al. 2020

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“…The study of precerebral and cerebral hemodynamics allows estimating the mechanisms of anatomic, myogenic, and metabolic reserves in cerebral blood flow regulation [24,25]. The literature provides the data on the effect of circulating hormones on cerebral blood flow regulation, in particular, on changes in the tone of brain vessels depending on the concentration of blood melatonin and estrogen/testosterone [26].…”

Section: Discussionmentioning

confidence: 99%

Analysis of muscle tone and strength and cerebral blood flow in kickboxers

Shevtsov

Сашенков

Шибкова

et al. 2019

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Purpose: the article deals with providing a characteristic of muscle and tone status as well as precerebral and cerebral hemodynamics in kickboxers. Materials: 102 athletes with the qualification from the Second-class Athlete to the Master of Sport voluntary participated in the study. The average age of athletes at the moment of the study was 20.90±0.50. The average sports experience of participants was equal to 4.15±2.77. The control group consisted of apparently healthy young males of the same age but not involved in sports activities (n=35). The indicators of muscle tone and strength and cerebral blood flow were studied with the help of Doppler ultrasound of the main arteries of the head, electroneuromyography, and transcranial Doppler. Results: the article provides the results of the study on the effect of muscle and tone disturbances in the spinal motion segment on the functional status of precerebral and cerebral blood flow. The disturbances in nerve conduction velocity in the symmetrical groups of trunk muscles are considered as the reason for muscle imbalance in 50% of athletes. The analysis of blood flow indicators in kickboxers with muscle imbalance revealed a typical increase in the tone of precerebral vessels and changes in the gradients of blood flow velocity in various segments of the carotid and vertebral arteries. The decrease of cerebral blood flow in athletes, in particular, the venous outflow of a dystonic nature, is the result of spasmodic and ischemic Doppler patterns against a decreased indicator of arteriovenous balance. Mild traumatic brain injuries should also be taken into account when speaking about the development of cerebrovascular dysfunction as a result of kickboxers’ sparring activities and competitions. Conclusions: Differentiated disturbances in sensory and motor conductivity result in the disturbance of afferentation and muscle imbalance intensity. Angiospasm and vascular ischemia determine the increase in the linear blood flow velocity in the carotid system and the decrease in the vessels of the vertebrobasilar system against the increase in resistivity indicators in the carotid basins and vertebrobasilar system in kickboxers. Correlation analysis revealed visceral motor correlations, which proved the influence of the functional status of the regional muscle system on cerebral hemodynamics. The analysis of tone and strength muscle characteristics and cerebral blood flow in kickboxers indicates the necessity of correcting muscle and tone asymmetry of the paravertebral area.

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Effects of exercise in normobaric hypoxia on hemodynamics during muscle metaboreflex activation in normoxia

Cited by 11 publications

References 53 publications

A brief bout of exercise in hypoxia reduces ventricular filling rate and stroke volume response during muscle metaboreflex activation

A brief bout of exercise in hypoxia reduces ventricular filling rate and stroke volume response during muscle metaboreflex activation

Muscle Oxygen Delivery in the Forearm and in the Vastus Lateralis Muscles in Response to Resistance Exercise: A Comparison Between Nepalese Porters and Italian Trekkers

Analysis of muscle tone and strength and cerebral blood flow in kickboxers

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