Effects of Exercise During Radiation Therapy on Physical Function and Treatment-Related Side Effects in Men With Prostate Cancer: A Systematic Review and Meta-Analysis

Schumacher, Oliver; Luo, Hao; Taaffe, Dennis R.; Galvão, Daniel A.; Tang, Colin; Chee, Raphael; Spry, Nigel; Newton, Robert U.

doi:10.1016/j.ijrobp.2021.06.034

Cited by 23 publications

(14 citation statements)

References 62 publications

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“…The relevance of such an intervention for this group is supported by Ursem et al reporting declining PF during radiotherapy for patients without any intervention to support PF [ 47 ]. Similar results were found in a recent meta-analysis which concluded that exercise interventions are beneficial for PF in prostate cancer patients undergoing radiation therapy [ 48 ].…”

Section: Discussionsupporting

confidence: 88%

Development and Evaluation of a Multimodal Supportive Intervention for Promoting Physical Function in Older Patients with Cancer

Shehu

Roggendorf

Golla

et al. 2022

Cancers

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Physical function (PF) in older patients with cancer may decline during and after oncologic therapy. This study aimed to develop and pilot test an individually tailored unsupervised physical activity (PA) program and dietary recommendations to promote PF in older patients with cancer. Following development and pretest, the intervention was pilot tested to explore feasibility, acceptance, adherence and potential benefit. Patients ≥60 years, with heterogeneous cancer diagnoses, starting outpatient radiotherapy were randomized in two study arms: paper-based vs. video-based instructions. Based on assessments of PF, PA, nutrition, cognition, mental health, social support, HRQOL and personal goals, participants received individual recommendations for PA and nutrition. After 12 weeks of intervention (T1), reassessments were performed. The postal 4-week follow-up questionnaire included PA, nutrition and HRQOL. Participants (n = 24, 14 female, mean age 70 ± 7 years) showed comparable characteristics in both study arms. The majority rated the program as helpful. Facilitators and barriers to PA adherence were collected. Both modes of instructions were appreciated equally. PF (EORTC QLQ-C30) declined slightly (not clinically relevant >10 pts.) at group level T0: 76 ± 16, T1: 68 ± 21, T2: 69 ± 24. The intervention was feasible, well accepted, showing potential benefit for the maintenance of PF during outpatient radiotherapy, and should be further tested in a larger sample.

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Section: Discussionsupporting

confidence: 88%

Development and Evaluation of a Multimodal Supportive Intervention for Promoting Physical Function in Older Patients with Cancer

Shehu

Roggendorf

Golla

et al. 2022

Cancers

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“…Only score changes between different dates were examined without the patient receiving any training from our side. Nevertheless, this could be investigated in further studies, as Zaorsky et al and Schumacher et al have shown that exercise therapy can be safely utilized during radiotherapy of various carcinomas and leads to increased “physical function” [ 17 , 18 , 19 ]. Furthermore, a number of meta-analyses have already shown that an improvement in physical activity after diagnosis has a positive effect on survival [ 6 , 11 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

Baseline Quality of Life of Physical Function Is Highly Relevant for Overall Survival in Advanced Rectal Cancer

et al. 2022

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In advanced rectal cancer, neoadjuvant radiochemotherapy and total mesorectal excision lead to long overall survival. The quality of life (QOL) of the patients is clearly related to the prognosis. Our question was whether the prognosis can be represented with only one question or one score from the QOL questionnaires. 360 consecutively recruited patients diagnosed with advanced rectal cancer were questioned during radiochemotherapy and a follow-up of 8 years. The questionnaires QLQ-C30 and QLQ-CR38 were used; 10 functional and 17 symptom scores were calculated. The functional score “physical function” and the symptom scores “fatigue”, “nausea and vomiting”, “pain” and “appetite loss” were highly prognostic (p < 0.001) for overall survival. “Physical function” was highly prognostic at all time points up to 1 year after starting therapy (p ≤ 0.001). The baseline “physical function” score divided the cohort into a favorable group with an 8-year overall survival rate of 70.4% versus an unfavorable group with 47.5%. In the multivariable analysis, baseline “physical function”, age and distant metastases were independent predictors of overall survival. The score “physical function” is a powerful unrelated risk factor for overall survival in patients with rectal cancer. Future analyses should study whether increased “physical function” after diagnosis could improve survival.

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“…The results highlighted the improvements in strength, endurance, and quality of life from the exercise training in comparison to the control group [ 7 ]. Further positive study results on physical activity parallel to adjuvant therapy are available, for example, with prostate cancer or breast cancer patients during radiotherapy [ 8 , 9 ]. Studies on the use of physical activity as part of inpatient treatment with non-small-cell lung cancer patients, with patients after a hematological stem cell transplant, and with lymphoma patients report a stabilization of exercise intensity and walking distance, an improvement in quality of life, and a reduction in fatigue symptoms [ 10 , 11 , 12 ].…”

Section: Physical Activity and Exercise Therapy In Different Therapy ...mentioning

confidence: 99%

Supportive Care in Oncology—From Physical Activity to Nutrition

et al. 2022

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The diagnosis and treatment of cancer are associated with impairment at the physical and at psychological level. In addition, side effects are a potentially treatment-limiting factor that may necessitate dose reduction, delay, or even discontinuation of therapy, with negative consequences for outcome and mean survival. Numerous studies have shown that physical activity and sports and exercise therapy programs are not only practicable but also recommendable for oncologic patients during the acute phase and in the aftercare. Furthermore, nutrition plays an important role in all stages of tumor therapy. A timely integration of a nutrition therapy and physical activity in the form of physiotherapy and sports therapy serves to prevent and reduce treatment-associated side effects. Evidence-based recommendations on cancer prevention through nutrition therapy, physical activity, and sports and exercise therapy should be integrated into treatment plans for oncology patients as well as in health care services for the general population. Individual counselling by trained nutrition and exercise specialists may be advisable to receive concrete recommendations on the respective tumor entity or specific side effects. This mini review is based on a selective literature search in the PubMed database and Cochrane Central Register of Controlled Trials on the subjects of healthy diet and physical activity in primary prevention and follow-up about cancer.

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Effects of Exercise During Radiation Therapy on Physical Function and Treatment-Related Side Effects in Men With Prostate Cancer: A Systematic Review and Meta-Analysis

Abstract: Effects of exercise during radiotherapy on physical function and treatment-related side effects in men with prostate cancer: a systematic review and meta-analysis,

Cited by 23 publications

References 62 publications

Development and Evaluation of a Multimodal Supportive Intervention for Promoting Physical Function in Older Patients with Cancer

Development and Evaluation of a Multimodal Supportive Intervention for Promoting Physical Function in Older Patients with Cancer

Baseline Quality of Life of Physical Function Is Highly Relevant for Overall Survival in Advanced Rectal Cancer

Supportive Care in Oncology—From Physical Activity to Nutrition

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