Effects of Exercise during Adjuvant Chemotherapy on Breast Cancer Outcomes

Abstract

This exploratory follow-up of the START provides the first randomized data to suggest that adding exercise to standard chemotherapy may improve breast cancer outcomes. A definitive phase III trial is warranted.

Exploring the Feasibility of a Broad-Reach Physical Activity Behavior Change Intervention for Women Receiving Chemotherapy for Breast Cancer: A Randomized Trial

“…Several well-designed studies have emerged demonstrating the feasibility and effectiveness of supervised exercise interventions for women with breast cancer receiving chemotherapy (e.g., enhanced HRQoL and fitness, reduced fatigue, and possibly breast cancer outcomes; refs. 2,6,41). These studies provide a good base of evidence on which to promote and advocate for supervised PA during this time period.…”

“…1). Breast cancer patients who engage in regular PA during chemotherapy have clinically significant improvements in health-related quality of life (HRQoL), physical functioning, fatigue, and cardiorespiratory fitness (2-5) and may even achieve improved disease-free survival (6). One study suggested women who were previously inactive and increased their PA after breast cancer diagnosis had a 45% lower risk of death compared with women who remained inactive after diagnosis (7).…”

Ćwiczenia fizyczne jako czynnik zapobiegający nowotworom i poprawiający rokowanie: dobrze udokumentowana metoda

“…Wpływ ćwiczeń fizycznych na czas do nawrotu i czas przeżycia u chorych na raka piersi i jelita grubego po radykalnym leczeniu jest przedmiotem toczących się obecnie badań z randomizacją: START (Supervised Trial of Areobic versus Resistance Training) i CHALLENGE (The Colon Health and Life-Long Exercise Change) [16][17][18].…”

Nutrition, Nitrogen Requirements, Exercise and Chemotherapy-Induced Toxicity in Cancer Patients. A puzzle of Contrasting Truths?

“…It has been demonstrated that physical exercise stimulates the mTOR pathway and this is correlated with the prevention of certain type of cancers [34][35][36]. mTOR can also increase tolerability of chemotherapy and can protect against autophagy (frequently associate with cancer resistance to therapy) and improve prognosis [37][38][39]. It is interesting that, it has been recently proposed that physical exercise and nutrients, such as amino acids, maintain protein synthesis and anabolism because they activate different pathways upstream of mTOR [30].…”