Effects of Exercise and Weight Loss on Cardiac Risk Factors Associated With Syndrome X

Watkins, Lana L.; Sherwood, Andrew; Feinglos, Mark N.; Hinderliter, Alan L.; Babyak, Michael A.; Gullette, Elizabeth C. D.; Waugh, Robert; Blumenthal, James A.

doi:10.1001/archinte.163.16.1889

Cited by 118 publications

(100 citation statements)

References 35 publications

(51 reference statements)

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“…Comparable trials, where exercise programs induced substantial weight loss in postmenopausal women, suggest that weight loss is important for favorable effects on insulin resistance (15,16,18,21,(38)(39)(40). For example, in the NEW trial, effects of weight The b (95% CI) is the treatment effect ratio representing the overall intervention effect on metabolic variable (adjusted for baseline), including changes from baseline to 4 months and 4 to 12 months.…”

Section: Discussionmentioning

confidence: 99%

Effect of Exercise on Insulin Sensitivity in Healthy Postmenopausal Women: The SHAPE Study

Gemert

Monninkhof

May

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: An inactive lifestyle is a risk factor for several types of cancer. A proposed pathway through which exercise influences cancer risk is via insulin. We aim to investigate the effect of a oneyear exercise intervention on insulin sensitivity, and the role of body fat in this association, in healthy, normal to overweight/ obese, postmenopausal women.Methods: In the Sex Hormones And Physical Exercise (SHAPE) study, 189 healthy, inactive and postmenopausal women [ages, 50-69 years; body mass index (BMI), 22-40 kg/m 2 ] were randomly assigned to a one-year aerobic and strength exercise intervention (150 min/wk), or a control group. Between-group differences in fasting insulin, glucose, and homeostatic model assessment of insulin resistance (HOMA2) over time were estimated using linear mixed models.Results: Follow-up measurements of insulin sensitivity were available for 181 (95.8%) and 182 (96.3%) women at 4 and 12

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Section: Discussionmentioning

confidence: 99%

Effect of Exercise on Insulin Sensitivity in Healthy Postmenopausal Women: The SHAPE Study

Gemert

Monninkhof

May

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…These results appear to be contradictory. Indeed, both lower physical activity and excess energy intake were reported to be associated with the MetS [8][9][10][11][28][29][30][31]. MetS is, as described above, essentially obesity in combination with a clustering of other MetRFs.…”

Section: Discussionmentioning

confidence: 99%

“…The effects of physical activity and energy intake on MetS have been examined in numerous studies [8][9][10][11][29][30][31][32]. However, few studies have examined their effects in non-obese subjects with a clustering of MetRFs.…”

Section: Discussionmentioning

confidence: 99%

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Lower physical activity is a risk factor for a clustering of metabolic risk factors in non-obese and obese Japanese subjects: The Takahata study

et al. 2013

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“…Other studies have shown that the majority of medical risk factors associated with obesity (diabetes, HTN) respond more to changes in weight than to changes in energy expenditure from exercise [28] . However, several studies have reported that weight maintenance following an intervention may be improved by continued exercise [9,10] .…”

Section: Discussionmentioning

confidence: 99%

http://www.ommegaonline.org/article-details/Obesity-Related-Hormones-and-Metabolic-Risk-Factors--A-Randomized-Trial-of-Diet-Plus-Either-Strength-or-Aerobic-Training-versus-Diet-Alone-in-Overweight-Participants/186

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Abstract:There is debate about the additive effects of exercise in conjunction with diet to treat obesity, and not much is known about the differential effects of strength versus aerobic training. This randomized controlled trial examined the effects of diet plus strength training, diet plus aerobic training, or diet only on metabolic risk factors associated with obesity. Eighty-one overweight and obese participants completed the 8-week intervention. All participants received an energy-restrictive formula diet with an energy content based on 70% of measured resting metabolic rate (RMR). Participants assigned to an exercise group trained 3 days/week under supervision. Anthropometrics and fasting hormones were assessed pre-and post-intervention. Mean weight loss (8.5 ± 4.3kg SD) did not differ between groups nor did reductions in BMI or body fat, although the diet plus strength training group showed marginally greater lean mass retention. There were significant improvements in the values and number of metabolic syndrome risk factors, and decreases in insulin concentrations and insulin resistance, which did not vary between groups. For men, testosterone increased significantly more in the diet plus aerobic training as compared to the other groups. As compared to diet alone, the addition of strength or aerobic training did not improve changes in BMI, body fat, or metabolic risk factors although the diet plus strength training group showed a trend toward preservation of lean mass, and the diet plus aerobic group in men resulted in increased testosterone.

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Effects of Exercise and Weight Loss on Cardiac Risk Factors Associated With Syndrome X

Abstract: These results suggest that EX + WL is an effective treatment for hyperinsulinemia and lowering of diastolic BP in patients with the syndrome X.

Cited by 118 publications

References 35 publications

Effect of Exercise on Insulin Sensitivity in Healthy Postmenopausal Women: The SHAPE Study

Effect of Exercise on Insulin Sensitivity in Healthy Postmenopausal Women: The SHAPE Study

Lower physical activity is a risk factor for a clustering of metabolic risk factors in non-obese and obese Japanese subjects: The Takahata study

http://www.ommegaonline.org/article-details/Obesity-Related-Hormones-and-Metabolic-Risk-Factors--A-Randomized-Trial-of-Diet-Plus-Either-Strength-or-Aerobic-Training-versus-Diet-Alone-in-Overweight-Participants/186

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