Effects of ethanol on visual evoked responses in monkeys performing a memory task

Fuster, Joaquı́n M.; Willey, T. Joe; Riley, Darrell M.; Ashford, J. Wesson

doi:10.1016/0013-4694(82)90138-9

Cited by 12 publications

(5 citation statements)

References 19 publications

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“…Ethanol distributes rapidly throughout the body, based on our observations that plasma levels stabilize relatively quickly and follow first-order elimination kinetics within 7 min following the end of the slow intravenous infusion. This observation is consistent with the relatively stable plasma ethanol levels within 5--10 min following similar, slow infusion protocols for monkeys reported previously (Fuster et al 1982;Kalhorn et al 1986;Bennett and DePetrillo 2004). The plasma levels of ethanol attained after the 0.2 and 0.5 g/kg intravenous dose approximate plasma levels observed after intragastric doses of 1 and 2 g/kg, respectively (Ando et al 1987;Katner et al 2004).…”

Section: Discussionsupporting

confidence: 89%

“…A similar altered response time distribution and elevated tau value is observed in clinical populations with attentional deficits (Leth-Steensen et al 2000;Castellanos et al 2005;Hervey et al 2006). An ethanol-induced decrease in attention was also hypothesized to underlie impaired performance of nonhuman primates on a delayed-match-to-sample task (Fuster et al 1982). More frequent attentional lapses in the presence of ethanol are also suggested by the increased time required to complete the selfpaced SD/Rev task due to delays in initiating trials but not in reaction times on trials once they had been initiated.…”

Section: Discussionmentioning

confidence: 99%

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The Acute Impact of Ethanol on Cognitive Performance in Rhesus Macaques

et al. 2010

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Decreased cognitive control over prepotent responses has been hypothesized to contribute to ethanol-induced behavioral disinhibition. However, the effects of ethanol on specific cognitive domains associated with decision making have not been extensively studied. We examined the impact of acute ethanol administration on cognitive performance of nonhuman primates. Studies were conducted using 0.2, 0.5, and 1 g/kg intravenous ethanol in rhesus macaques performing touch screen-based tasks examining stimulus discrimination, stimulus reversal, and stimulus response performance. The impact on attentional processing was also evaluated. Ethanol reduced the accuracy of reversal performance marginally at 0.2 g/kg and significantly at 0.5 g/kg. This effect was selective given an absence of impairment on the stimulus discrimination and stimulus response tasks at these doses. Performance on stimulus discrimination was impaired at 1.0 g/kg, which prevented determination of reversal performance. Analysis of post-error response times demonstrated that error processing was impaired at both 0.2 and 0.5 g/kg. Ethanol also increased the number of omissions and delayed responses on an attentional task, suggesting more frequent attentional lapses. These data demonstrate that cognitive function mediated by specific prefrontal cortical brain regions is particularly sensitive to ethanol and suggest specific cognitive mechanisms that may underlie harmful decisions made at low doses of ethanol.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

The Acute Impact of Ethanol on Cognitive Performance in Rhesus Macaques

et al. 2010

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“…Evoked-potential recordings in awake behaving monkeys have shown that ethanol reduces visual responses in a variety of brain areas, including the lateral geniculate nucleus, the striate cortex, and the inferotemporal cortex (Fuster et al 1982). A reduction of the P1 and N1 visual ERP components has been found in many studies in human subjects (for review see Jääskeläinen et al 1996).…”

Section: Discussionmentioning

confidence: 99%

Effects of ethanol on anti-saccade task performance

et al. 2003

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“…Similar to sleep loss, the effect of alcohol on attention is well documented, 40 especially with respect to deficits in sustained attention. [41][42][43][44][45] Evidence suggests clear impairment in the voluntary control of attention following alcohol intake. Utilising an antisaccade task, alcohol (BAC 0.07%) has consistently led to slower latencies for correctly directed antisaccades.…”

Section: Introductionmentioning

confidence: 99%