Alcohol and Sleep Restriction Combined Reduces Vigilant Attention, Whereas Sleep Restriction Alone Enhances Distractibility

Lee, James Cheng Yen; Manousakis, Jessica E.; Fielding, Joanne

doi:10.5665/sleep.4672

Cited by 32 publications

(29 citation statements)

References 96 publications

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“…Given the previously observed up-regulation of A 1 AR availability with extended time awake (28,29), the cerebral adenosine system might therefore represent a common pathway for both ethanol and sleep deprivation effects on performance. Behavioral studies have established a link between both stressors, providing evidence for additive or even synergistic detrimental effects on cognitive performance (30)(31)(32)(33). The large interindividual variation in the susceptibility of cognitive performance to acute and chronic sleep deprivation that we found here substantiates previous reports (15,34) and is consistent with a genetic contribution (e.g., refs.…”

Section: Discussionsupporting

confidence: 91%

Cognitive impairments by alcohol and sleep deprivation indicate trait characteristics and a potential role for adenosine A ₁ receptors

Elmenhorst

Benderoth

et al. 2018

Proc. Natl. Acad. Sci. U.S.A.

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Trait-like differences in cognitive performance after sleep loss put some individuals more at risk than others, the basis of such disparities remaining largely unknown. Similarly, interindividual differences in impairment in response to alcohol intake have been observed. We tested whether performance impairments due to either acute or chronic sleep loss can be predicted by an individual's vulnerability to acute alcohol intake. Also, we used positron emission tomography (PET) to test whether acute alcohol infusion results in an up-regulation of cerebral A adenosine receptors (AARs), similar to the changes previously observed following sleep deprivation. Sustained attention in the psychomotor vigilance task (PVT) was tested in 49 healthy volunteers (26 ± 5 SD years; 15 females) () under baseline conditions: () after ethanol intake, and after either () total sleep deprivation (TSD; 35 hours awake; = 35) or () partial sleep deprivation (PSD; four nights with 5 hours scheduled sleep; = 14). Ethanol- versus placebo-induced changes in cerebral AAR availability were measured in 10 healthy male volunteers (31 ± 9 years) with [F]8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine (CPFPX) PET. Highly significant correlations between the performance impairments induced by ethanol and sleep deprivation were found for various PVT parameters, including mean speed (TSD, = 0.62; PSD, = 0.84). AAR availability increased up to 26% in several brain regions with ethanol infusion. Our studies revealed individual trait characteristics for being either vulnerable or resilient to both alcohol and to sleep deprivation. Both interventions induce gradual increases in cerebral AAR availability, pointing to a potential common molecular response mechanism.

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Section: Discussionsupporting

confidence: 91%

Cognitive impairments by alcohol and sleep deprivation indicate trait characteristics and a potential role for adenosine A ₁ receptors

Elmenhorst

Benderoth

et al. 2018

Proc. Natl. Acad. Sci. U.S.A.

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“…Participants took a 30‐ml sip of this drink every minute for 16 min (Filtness, Rudin‐Brown, Mulvihill, & Lenné, ). Alcohol volume was calculated according to each participant's height, weight, and sex as described previously (J. Lee, Manousakis, Fielding, & Anderson, ).…”

Section: Methodsmentioning

confidence: 99%

Impairment due to combined sleep restriction and alcohol is not mitigated by decaying breath alcohol concentration or rest breaks

Manousakis

Anderson

2017

Human Psychopharmacology

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“…Prolonged driving durations can lead to lapses in attention and consequently increase the risk of experiencing a traffic accident [2][3][4] . Approximately 10-25 percent of fatal road accidents worldwide result from attentional failure, where the ability to detect and respond to road-traffic information is impaired [5][6][7][8] . In Australia, such attention-related road accidents are estimated to cost the economy approximately 3 billion dollars per year 9 .…”

Section: Introductionmentioning

confidence: 99%

Monotonous driving induces shifts in spatial attention as a function of handedness

Chandrakumar¹,

Coussens²,

Keage³

et al. 2020

Preprint

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Current evidence suggests that the ability to detect and react to information under lowered alertness conditions might be more impaired on the left than the right side of space. This evidence derives mainly from right-handers being assessed in computer and paper-and-pencil spatial attention tasks. However, there are suggestions that left-handers might show impairments on the opposite (right) side compared to right-handers with lowered alertness, and it is unclear whether the impairments observed in the computer tasks have any real-world implications for activities such as driving. The current study investigated the alertness and spatial attention relationship under simulated monotonous driving in left- and right-handers. Twenty left-handed and 22 right-handed participants (15 males, mean age=23.6y, SD=5.0y) were assessed on a simulated driving task (lasting approximately 60 minutes) to induce a time-on-task effect. The driving task involved responding to stimuli appearing at six different horizontal locations on the screen, whilst driving in a 50km/h zone. Decreases in alertness and driving performance were evident with time-on-task in both handedness groups. We found handedness impacts reacting to lateral stimuli differently with time-on-task: right-handers reacted slower to the leftmost stimuli, while left-handers showed the opposite pattern (although not statistically significant) in the second compared to first half of the drive. Our findings support suggestions that handedness modulates the spatial attention and alertness interactions. The interactions were observed in a simulated driving task which calls for further research to understand the safety implications of these interactions for activities such as driving.

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Alcohol and Sleep Restriction Combined Reduces Vigilant Attention, Whereas Sleep Restriction Alone Enhances Distractibility

Abstract: Our data reveal specific signatures for sleep related attention failure: the voluntary allocation of attention is impaired, whereas the involuntary allocation of attention is enhanced. This provides key evidence for the role of distraction in attention failure during sleep loss.

Cited by 32 publications

References 96 publications

Cognitive impairments by alcohol and sleep deprivation indicate trait characteristics and a potential role for adenosine A ₁ receptors

Cognitive impairments by alcohol and sleep deprivation indicate trait characteristics and a potential role for adenosine A ₁ receptors

Impairment due to combined sleep restriction and alcohol is not mitigated by decaying breath alcohol concentration or rest breaks

Monotonous driving induces shifts in spatial attention as a function of handedness

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Alcohol and Sleep Restriction Combined Reduces Vigilant Attention, Whereas Sleep Restriction Alone Enhances Distractibility

Abstract: Our data reveal specific signatures for sleep related attention failure: the voluntary allocation of attention is impaired, whereas the involuntary allocation of attention is enhanced. This provides key evidence for the role of distraction in attention failure during sleep loss.

Cited by 32 publications

References 96 publications

Cognitive impairments by alcohol and sleep deprivation indicate trait characteristics and a potential role for adenosine A 1 receptors

Cognitive impairments by alcohol and sleep deprivation indicate trait characteristics and a potential role for adenosine A 1 receptors

Impairment due to combined sleep restriction and alcohol is not mitigated by decaying breath alcohol concentration or rest breaks

Monotonous driving induces shifts in spatial attention as a function of handedness

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Product

Resources

About

Cognitive impairments by alcohol and sleep deprivation indicate trait characteristics and a potential role for adenosine A ₁ receptors

Cognitive impairments by alcohol and sleep deprivation indicate trait characteristics and a potential role for adenosine A ₁ receptors