Effects of Ethanol on in Vivo Cystometry and in Vitro Whole Bladder Contractility in the Rat

Abstract

Ethanol significantly impairs detrusor contractility in the rat in vivo and in vitro.

Effects of Ethanol on Intracorporeal Structures of the Rat

“…Elastic and easily expandable erectile tissue provides adequate compressive and stretching forces to drain the subtunical venules and cause high venous outflow resistance [18]. Changes in those structures may cause decreased relaxation of erectile tissue and affect the normal filling of the vascular spaces [19,20]. In our study we observed a significant decrease in the content of EF (p=0.002).…”

“…It is known that acute ethanol intoxication can cause urinary retention in benign prostatic hyperplasia [17]. In animal studies, the mechanism of urinary retention induced by ethanol partly showed that ethanol significantly impaired detrusor contractility in vivo and in vitro [18][19][20]. Several in vitro studies have revealed that ethanol had significant effect on both contractility and relaxation of rabbit corpus cavernosal smooth muscle (CCSM) [12][13][14].…”

Effects of ethanol and its metabolite acetaldehyde on responses of the rat bladder

“…It is known that acute ethanol intoxication can cause urinary retention in patients with BPH [ 1, 2]. In animal studies, ethanol significantly impaired detrusor contractility in vivo and in vitro [ 2, 7]. The primary enzymatic steps in ethanol metabolism to acetaldehyde, acetate, CO 2 and water have been known for many decades but the implications of this for smooth muscle contractility have often not been recognised [ 4].…”

Ätiologie und Pathogenese der Blasenüberaktivität

“…bilateraler Ligatur der A. iliaca interna bei Ratten zu induzieren, was zu gesteigerter Miktionsfrequenz, dem Auftreten von Detrusorhyperaktivitäten und Reduktion des maximalen Detrusordruckes führte [26]. [27,28]. Ursächlich werden Urothelschä-den, ein submuköses und intramuskulä-res Ödem sowie eine glattmuskuläre Degeneration beschrieben [26,27,28].…”

“…[27,28]. Ursächlich werden Urothelschä-den, ein submuköses und intramuskulä-res Ödem sowie eine glattmuskuläre Degeneration beschrieben [26,27,28]. Die Blasenüberaktivität wird einer Neurodegeneration mit konsekutivem Anstieg des NGF zugeschrieben [26,29].…”