2006
DOI: 10.1007/s11255-005-3150-4
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Effects of Ethanol on Intracorporeal Structures of the Rat

Abstract: Our findings suggest that in this animal model chronic ethanol exposure decreases the percentage of staining for smooth muscle actin, elastin, and collagen type 4 which are the key structures fundamental for erection.

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Cited by 6 publications
(11 citation statements)
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References 21 publications
(32 reference statements)
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“…In addition to changes in collagen, we detected a decrease in elastin content in response to ETOH. This finding is in agreement with published data whereby EtOH attenuated levels of elastic fibers in smooth muscle cells [YeS silli et al, 2006]. Thus, the increase of fibrillar collagen I and/ or III in combination with decreased elastic fibers may contribute to the characteristic syndrome of fibrotic diseases.…”
Section: Discussionsupporting
confidence: 93%
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“…In addition to changes in collagen, we detected a decrease in elastin content in response to ETOH. This finding is in agreement with published data whereby EtOH attenuated levels of elastic fibers in smooth muscle cells [YeS silli et al, 2006]. Thus, the increase of fibrillar collagen I and/ or III in combination with decreased elastic fibers may contribute to the characteristic syndrome of fibrotic diseases.…”
Section: Discussionsupporting
confidence: 93%
“…Conversely, studies using skin fibroblasts have shown a decrease in collagen I, albeit in conjunction with an increase in collagen III [Ranzer et al, ]. In smooth muscle cells, on the other hand, chronic EtOH exposure to rats decreases elastic fiber and collagen IV [Yeşilli et al, ].…”
mentioning
confidence: 99%
“…(HYUNG et al, 2000;SAITO et al, 1994). Yesilli et al (2006) Adicionado a estes resultados, Yesilli et al (2006) também observaram alterações no conteúdo de fibras colágenas e elásticas do tecido cavernoso. O conteúdo colágeno e elástico tem papel importante na capacidade do corpo cavernoso em alcançar rigidez, complacência e elasticidade durante a ereção.…”
Section: Discussionunclassified
“…Não encontramos na literatura, estudos semelhantes para discussão. No seu trabalho, Yesilli et al (2006) observaram por avaliação histoquímica, decréscimo significante no conteúdo de fibras elásticas (p=0.002) nos animais alcoolizados, comparados aos animais controle.…”
Section: Discussionunclassified
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