Effects of estrogen on food intake, serum leptin levels and leptin mRNA expression in adipose tissue of female rats

Fungfuang, Wirasak; Terada, Misao; Komatsú, Noriyuki; Moon, Changjong; Saitô, Tôru

doi:10.5625/lar.2013.29.3.168

Cited by 37 publications

(25 citation statements)

References 28 publications

(35 reference statements)

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“…Similarly, estrogen levels are linked with appetite. Animal studies have found that estrogen treatment leads to significantly higher serum leptin levels and lower food intake (28). Klump et al showed that increases in DEBQ Emotional Eating Scale scores were associated with decreases in estradiol and increases in progesterone across the menstrual cycle among women in community samples (23).…”

Section: Discussionmentioning

confidence: 99%

The Impact of Menstrual Cycle Phases on Cardiac Autonomic Nervous System Activity: An Observational Study Considering Lifestyle (Diet, Physical Activity, and Sleep) among Female College Students

Tada

Yoshizaki

Tomata

et al. 2017

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Summary Studies examining the impact of menstrual cycle phases on the cardiac autonomic nervous system have produced inconsistent results. This study aimed to investigate this relationship, controlling for the confounding effects of diet, physical activity, and sleep, which can be affected by the menstrual cycle. Fifteen female college students with regular menses were enrolled. Data regarding 24-h heart rate variability (HRV), dietary intake, eating behavior, menstrual distress, and sleep and activity parameters were obtained during the follicular and luteal phases. Power spectral analysis of HRV was used to calculate low-frequency (0.04-0.15 Hz, LF), high-frequency (.0.15 Hz, HF), and total spectral power (TP). Cardiac sympathetic and parasympathetic nervous system activity indicators were evaluated as LF/HF and HF/TP, respectively. Intake of protein and fat, as well as total sleep time and number of awakenings, were higher in the luteal phase than in the follicular phase (p,0.05). Tendencies for increased mean activity counts, emotional eating scores, and behavioral change scores in the Menstrual Distress Questionnaire were observed in the luteal phase (p,0.10). Although LF/HF was higher in the luteal phase (p50.036), the relationship was weakened after controlling for diet, physical activity, and sleep (p50.113). Our findings suggest that altering sympathetic nervous system activity during the menstrual cycle was not independent from major lifestyle factors (diet, physical activity, and sleep). Menstrual cycle phase and changes of these parameters should be considered when assessing the cardiac autonomic function among menstruating woman.

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Section: Discussionmentioning

confidence: 99%

The Impact of Menstrual Cycle Phases on Cardiac Autonomic Nervous System Activity: An Observational Study Considering Lifestyle (Diet, Physical Activity, and Sleep) among Female College Students

Tada

Yoshizaki

Tomata

et al. 2017

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…18 Estrogen is also known have a role in the regulation of orexigenic neuropeptides such as NPY and grelin, and anorexigenic neuropeptides like insulin, leptin and serotonin. 19 In addition, studies reveals that estrogen deficiency causes excessive production of NPY in the hypothalamus and central leptin sensitivity disorders that causes an increase food intake and contributes to obesity. The results of paired t-test showed that there was a significant increase in the value of the index Lee before and after ovariectomy both in ovariectomy and non ovariectomy group.…”

Section: -17mentioning

confidence: 99%

The effect of long-term high-fat diet in ovariectomized Wistar rat on leptin serum levels

2016

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Leptin and estrogen have an important role in energy homeostasis through anorexic effects on the central nervous system. These hormones can decrease food intake, increases energy expenditure and thermogenesis. Long-term high-fat diet can lead to impaired leptin function. Moreover, estrogen, deficiency is a risk factor of obesity in menopause. The aim of this study is to investigate the effect of long-term high-fat diet on leptin serum levels in ovariectomized rats. Twenty-eight female Wistar rats (Rattus norvegicus) aged 6-8 weeks with body weight 120-150 g were used in this study. Rats were divided into 4 groups i.e. OVXSC groups: rat were ovariectomized and given a standard diet; OVXH groups: rat were ovariectomized and given a high-fat diet; SHAMSC groups: rat were not ovariectomized and given a standard diet; SHAMHF groups : rat were not ovariectomized and given a high-fat diet. Pre-post test with control group design for measurement of serum leptin levels, food intake, and Lee index. While post-test only control group design for measurement of abdominal fat mass. Pearson test was used to analyze the correlation between leptin serum levels, food intake, Lee index and abdominal fat mass. Paired t-test was used to analyze the differences between values before and after being treated. The daily food intake dropped in rat fed a high-fat diet although it was not statistically significant (p>0.05). Ovariectomy significantly increase Lee index (p<0.05). Obesity occurs in ovariectomized group, both of high-fat diet and standard diet. Abdominal fat mass was significantly higher in high-fat compared to standard diet group (p<0.05). Increase in levels of serum leptin highest in OVX-HF group (16.45 ± 8.75 ng/mL), and the lowest in the SHAM-SC (2.98 ± 1.61 ng/mL). In conclusion, serum leptin levels positively correlated with Lee index and abdominal fat mass, but negatively correlated with daily food intake. ABSTRAKLeptin dan estrogen memiliki peran penting dalam homeostasis energi melalui efek anoreksigenik pada sistem saraf pusat. Kedua hormon ini dapat menurunkan asupan makan, meningkatkan pengeluaran energi, dan termogenesis. Diet tinggi lemak jangka panjang dapat menyebabkan fungsi leptin terganggu. Selain itu, defisiensi estrogen merupakan faktor risiko terjadinya obesitas pada menopause. Penelitian ini bertujuan mengkaji efek pemberian diet tinggi lemak jangka panjang terhadap kadar leptin serum pada tikus yang diovariektomi. Sebanyak 28 ekor tikus Wistar betina berumur 6-8 minggu dengan berat J Med Sci, Volume 48, No. 2, 2016 April: 69-80 70 120-150 g digunakan dalam penelitian. Tikus dibagi menjadi 4 kelompok, yaitu kelompok tikus ovariektomi dan diberi diet standar (OVX-SC), kelompok tikus ovariektomi dan diberi diet tinggi lemak (OVX-HF), kelompok tikus tidak ovariektomi dan diberi diet standar (SHAM-SC), kelompok tikus tidak ovariektomi dan diberi diet tinggi lemak (SHAM-HF). Penelitian ini menggunakan metode eksperimental murni dengan pre-post test with control group design untuk pengukuran kadar l...

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“…These observations suggest a key role of estrogens in lipid distribution and metabolism homeostasis. In rodents, E2 treatment opposes obesity in both males and females (83) and reduces food intake, increases lipolysis and physical activity (89)(90)(91).…”

Section: Lxr Function: Sex Differencesmentioning

confidence: 99%

Liver X receptors as regulators of metabolism

Korach-André

Gustafsson²

2015

Biomolecular Concepts

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Abstract:The liver X receptors (LXR) are crucial regulators of metabolism. After ligand binding, they regulate gene transcription and thereby mediate changes in metabolic pathways. Modulation of LXR and their downstream targets has appeared to be a promising treatment for metabolic diseases especially atherosclerosis and cholesterol metabolism. However, the complexity of LXR action in various metabolic tissues and the liver side effect of LXR activation have slowed down the interest for LXR drugs. In this review, we summarized the role of LXR in the main metabolically active tissues with a special focus on obesity and associated diseases in mammals. We will also discuss the dual interplay between the two LXR isoforms suggesting that they may collaborate to establish a fine and efficient system for the maintenance of metabolism homeostasis.

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Effects of estrogen on food intake, serum leptin levels and leptin mRNA expression in adipose tissue of female rats

Cited by 37 publications

References 28 publications

The Impact of Menstrual Cycle Phases on Cardiac Autonomic Nervous System Activity: An Observational Study Considering Lifestyle (Diet, Physical Activity, and Sleep) among Female College Students

The Impact of Menstrual Cycle Phases on Cardiac Autonomic Nervous System Activity: An Observational Study Considering Lifestyle (Diet, Physical Activity, and Sleep) among Female College Students

The effect of long-term high-fat diet in ovariectomized Wistar rat on leptin serum levels

Liver X receptors as regulators of metabolism

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