Effects of estrogen on acetylcholine release in frontal cortex of female rats: involvement of serotonergic neuronal systems

Matsuda, Yoshito; Hirano, Hirohiko; Watanabe, Yoshifumi

doi:10.1016/s0006-8993(02)02465-4

Cited by 30 publications

(26 citation statements)

References 48 publications

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“…Female rats were ovariectomized (OVX), and half of the rats received estrogen replacement by insertion of a 0.5 mg timed release tablet that maintains estrogen levels within the range observed naturally during the proestrous phase (OVX + E; Matsuda, Hirano, & Watanabe, 2002). The rats were also implanted with recording electrodes just above dorsal striatum.…”

Section: Are Hippocampus and Striatum Differentially Regulated By Intmentioning

confidence: 99%

Parallel processing across neural systems: Implications for a multiple memory system hypothesis

Mizumori

Yeshenko

Gill

et al. 2004

Neurobiology of Learning and Memory

108

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Section: Are Hippocampus and Striatum Differentially Regulated By Intmentioning

confidence: 99%

Parallel processing across neural systems: Implications for a multiple memory system hypothesis

Mizumori

Yeshenko

Gill

et al. 2004

Neurobiology of Learning and Memory

108

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“…At least two transmitters, serotonin and enkephalin, have been implicated in indirect release of acetylcholine in the presence of estrogens. Stimulation of serotonin by estrogens can increase acetylcholine release in the frontal cortex as measured by in vivo microdialysis via activation of presynaptic 5HT 1A receptors (Matsuda et al, 2002). Estrogen can stimulate enkephalin release and subsequent mu-opioid receptor (MOR) activation in other brain areas (Eckersell et al, 1998).…”

Section: Vacht-labeled Terminals Apposed Er␣-ir Profilesmentioning

confidence: 99%

Subcellular relationships between cholinergic terminals and estrogen receptor‐α in the dorsal hippocampus

Towart

Alves

Znamensky

et al. 2003

J of Comparative Neurology

105

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Cholinergic septohippocampal neurons are affected by circulating estrogens. Previously, we found that extranuclear estrogen receptor-alpha (ERalpha) immunoreactivity in presynaptic profiles had an overlapping distribution with cholinergic afferents in the rat hippocampal formation. To determine the subcellular relationships between cholinergic presynaptic profiles and ERalpha, hippocampal sections were dually immunolabeled for vesicular acetylcholine transporter (VAChT) and ERalpha and examined by electron microscopy. Within the hippocampal formation, immunoreactivities for VAChT and ERalpha both were presynaptic, although their subcellular targeting was distinct. VAChT immunoreactivity was found exclusively within presynaptic profiles and was associated with small synaptic vesicles, which usually filled axon terminals. VAChT-labeled presynaptic profiles were most concentrated in stratum oriens of the hippocampal CA1 region and dentate inner molecular layer and hilus. In contrast, ERalpha immunoreactivity was found in clusters affiliated either with select vesicles or with the plasmalemma within preterminal axons and axon terminals. ERalpha-immunoreactive (IR) presynaptic profiles were more evenly distributed between hippocampal lamina than VAChT-IR profiles. Quantitative ultrastructural analysis revealed that VAChT-IR presynaptic profiles contained ERalpha immunoreactivity (ranging from 3% to 17%, depending on the lamina). Additionally, VAChT-IR presynaptic profiles apposed ERalpha-IR dendritic spines, presynaptic profiles, and glial profiles; many of the latter two types of profiles abutted unlabeled dendritic spines that received asymmetric (excitatory-type) synapses from unlabeled terminals. The presence of ERalpha immunoreactivity in cholinergic terminals suggests that estrogen could rapidly and directly affect the local release and/or uptake of acetylcholine. The affiliation of cholinergic terminals with excitatory terminals near ERalpha-labeled dendritic spines or glial profiles suggests that alterations in acetylcholine release could indirectly affect estrogen-modulated structural plasticity.

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“…Furthermore, neurotrophic effects of estrogen may explain how this hormone could have a protective action against cognitive deficit during aging (3,4).…”

Section: Received February 25 2010 Accepted September 23 2010 Avamentioning

confidence: 99%

Effects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled study

Santos-Galduróz

Galduróz

Facco

et al. 2010

Braz J Med Biol Res

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Effects of estrogen on acetylcholine release in frontal cortex of female rats: involvement of serotonergic neuronal systems

Cited by 30 publications

References 48 publications

Parallel processing across neural systems: Implications for a multiple memory system hypothesis

Parallel processing across neural systems: Implications for a multiple memory system hypothesis

Subcellular relationships between cholinergic terminals and estrogen receptor‐α in the dorsal hippocampus

Effects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled study

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