Effects of estradiol-17β, testosterone and a black cohosh preparation on bone and prostate in orchidectomized rats

Seidlová-Wuttke, Dana; Jarry, Hubertus; Pitzel, L.; Wuttke, W.

doi:10.1016/j.maturitas.2004.07.007

Cited by 25 publications

(22 citation statements)

References 37 publications

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“…On a model of OVX-R, CR was able to exert significant bone-sparing effect, as documented quantitatively by computer tomography (Seidlová-Wuttke et al, 2005). The bone-protective effect of Cimicifuga triterpenoids was devoid of the undesired proliferative effects on the uterus exerted by the estrogens in ovariectomized mice (OVX-M) (Li et al, 2007).…”

Section: Animal Studiesmentioning

confidence: 94%

Osteoprotective Medicinal Plants - Part 1 (A Human Clinical Evidence-Based Review)

Dragoș¹,

Gîlcă²,

Găman³

et al. 2017

Afr J Tradit Complement Altern Med

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Background. Osteoporosis is a bone metabolic disease affecting a large percentage of aging population, which leads to an increased risk of fractures and has a negative impact on life quality. The available treatments for osteoporosis are effective, but are associated with several severe adverse reactions, hence the interest for alternative treatments devoid of such redoubtable side effects. Medicinal plants represent a viable resource for new therapeutic agents. The purpose of this review is to provide an overview about the medicinal plants that have been reported to have antiosteoporotic effects in human clinical studies. Materials and Methods. Relevant studies found in PubMed database, pertaining to efficacy in humans, mechanism of action, osteoactive phytochemicals and safety, were selected. For the inquiry, keywords such as "medicinal plant", "osteoporosis", "bone", "fracture", "osteoclast" and "osteoblast" were used in various combinations. The information extracted was integrated with the traditional knowledge on the correspondent medicinal plants. List of abbreviations: BMD-bone mineral density; CQ-Cissus quadrangularis; CR-Cimicifuga racemose; ESEleutherococcus senticosus; IGF-insulin like growth factor; OPG-osteoprotegerin; OVX-M -ovariectomized mice; OVX-R-ovariectomized rats; PC -Pueraria candollei; PL -Pueraria lobate; PN-Panax notoginseng; RANK-receptor activator of NF-kB; RANKL-receptor activator of NF-kB ligand; ROS -reactive oxygen species; Runx 2-runt related transcription factor 2; SM-Salvia milthiorriza Results. Eight medicinal plants (Cimicifuga racemosa, IntroductionOsteoporosis and osteopenia (low bone density) are bone metabolic diseases affecting a large percentage of aging population, increasing the risk of fractures and having a negative impact on quality of life patients. Risk factors for osteoporosis are: hormonal related risk factors (menopausal and andropausal hormonal disturbances, early menopause, Article HistoryReceived: Jan. 5, 2017. Revised Received: Apr. 7, 2017. Accepted Apr. 12, 2017. Published Online: Nov. 15, 2017 103 hyperparathyroidism, hyperthyroidism), environmental related risk factors (e.g. dioxin-related compounds, heavy metals), nutrition-related risk factors (vitamin D, calcium deficiencies), lifestyle related risk factors (e.g. smoking, sedentarism), drugs (corticosteroids, anticonvulsants, aromatase inhibitors, gonadotropin-releasing hormone agonists), advanced age, female gender (Gonzalez-Macias et al., 2015;Paunescu et al., 2013;Rzymski et al., 2015).Osteoporosis is caused by disturbances of bone remodeling process. The bone tissue is undergoing permanent build-up by osteoblasts and breakdown by osteoclasts. A good dynamic balance between the osteoblastogenesis and osteoclastogenesis is the key for a bone matrix of a high quality. The disbalance occurs especially when the breakdown process overwhelms the building process, being triggered by the risk factors (Leung and Siu, 2013).There are several factors important for osteoblastogenesis, such as run...

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Section: Animal Studiesmentioning

confidence: 94%

Osteoprotective Medicinal Plants - Part 1 (A Human Clinical Evidence-Based Review)

Dragoș¹,

Gîlcă²,

Găman³

et al. 2017

Afr J Tradit Complement Altern Med

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“…Hot water-soluble fraction exhibited a tendency of preventive effect of anal ulcer induced by lactic acid. Isoferulic acid (157), ferulic acid (161) and caffeic acid (153) proved to be the active components responsible for the antiinflammatory activity, however, no significant difference for their activity was observed between the 3 compounds. The water decoction of C. heracleifolia is more potent than that of C. dahurica using carrageenin air-pouch inflammation test [135].…”

Section: Antimalarial Activitymentioning

confidence: 98%

“…Compounds 157 and 161 significantly reduced murine interleukin-8 production in vivo and in vitro with a dose-dependent manner [136] and 161 also inhibited the production of macrophage inflammatory protein-2 (MIP-2), tumor necrosis factor (TNF)-α in lipopolysaccharide (LPS)-stimulated RAW264.7 cells, a murine macrophage cell line [137]. Furthermore, an inhibitory activity of caffeic acid (153), Isoferulic acid (157), fukinoic acid (178), cimicifugic acid A (175), B (176), E (170) and F (171) on neutrophil elastase (EC 3.4.21.37) was tested [98]. As shown in Table 3, all of the tested compounds with Fukiic acid (174) moiety showed much more potent inhibitory activity, in which phenolic hydroxyl groups were closely related to the activity, such as fukinoic acid (178) with 3 OH groups was the strongest one.…”

Section: Remifeminmentioning

confidence: 99%

Cimicifugae Rhizoma: From Origins, Bioactive Constituents to Clinical Outcomes

Publisher¹

2006

CMC

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Cimicifugae Rhizoma, mainly originated from C. acerina, C. dahurica, C. foetida, C. heracleifolia, C. racemosa and C. simplex, has long been used in traditional medicine system. During the past 45 years, a lot of efforts have been dedicated to the studies on their bioactive constituents, pharmacological effects and clinical uses, and a variety of biological activities including relief of hot flash, anti-osteoporosis, anti-human immunodeficiency virus (HIV), antiinflammatory, antidiabetes, antimalaria and vasoactive property have been discovered. Although C. racemosa is widely applied to relieve menopause symptoms in clinic for its hormonal-like action, meaningfully, no estrogenic effect was confirmed up to date. The purpose of this paper is to systematically highlight these achievements and the further therapeutic potential. The origins and distributions of the rhizome are simply listed and phytochemical aspects including over 200 compounds mainly belonging to cycloartane-type triterpenoids have been summarized. The pharmacological characterizations, especially, as a clinically effective phytomedicine, the effects of the rhizoma on menopause symptoms and the clinical applications including possible mechanism have been reviewed in detail. Various in vivo, in vitro studies on the anti-bone resorption effects of the triterpenoids, together with structure-activity relationships are also incorporated to explore the therapeutic potential on osteoporosis, a major public health threat for postmenopausal women.

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“…Similar to estrogen, three day BCE treatment reduced serum LH in ovariectomized rats, although 14 day treatment did not (Jarry and Harnischfeger, 1985). The most consistent evidence of an estrogenic effect of BCE is on the bone (Seidlova-Wuttke et al 2005, Seidlova-Wuttke et al 2003a, Seidlova-Wuttke et al 2003b, Nisslein and Freudenstein, 2003a, Viereck et al 2005). …”

Section: Introductionmentioning

confidence: 99%

Black Cohosh: Insights into its Mechanism(s) of Action

Ruhlen

Sun

Sauter

2008

Integr Med�Insights

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The Women's Health Initiative found that combination estrogen and progesterone hormone replacement therapy increases breast cancer and cardiovascular disease risk, which compelled many women to seek herbal alternatives such as black cohosh extract (BCE) to relieve their menopausal symptoms. While several clinical trials document the effi cacy of BCE in alleviating menopausal symptoms, preclinical studies to determine how BCE works have yielded confl icting results. Part of this is because there is not a universally accepted method to standardize the dose of black cohosh triterpenes, the presumed active ingredients in the extract. Although the mechanism by which BCE relieves symptoms is unknown, several hypotheses have been proposed: it acts 1) as a selective estrogen receptor modulator, 2) through serotonergic pathways, 3) as an antioxidant, or 4) on infl ammatory pathways. We found that while the most prominent triterpene in BCE, 23-epi-26-deoxyactein, suppresses cytokine-induced nitric oxide production in brain microglial cells, the whole BCE extract actually enhanced this pathway. A variety of activities have been reported for black cohosh and its compounds, but the absorption and tissue distribution of these compounds is unknown.

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Effects of estradiol-17β, testosterone and a black cohosh preparation on bone and prostate in orchidectomized rats

Cited by 25 publications

References 37 publications

Osteoprotective Medicinal Plants - Part 1 (A Human Clinical Evidence-Based Review)

Osteoprotective Medicinal Plants - Part 1 (A Human Clinical Evidence-Based Review)

Cimicifugae Rhizoma: From Origins, Bioactive Constituents to Clinical Outcomes

Black Cohosh: Insights into its Mechanism(s) of Action

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