Effects of escin on acute inflammation and the immune system in mice

Wang, Tian; Fu, Fenghua; Zhang, Leiming; Han, Bin; Zhu, Mei; Zhang, Xiumei

doi:10.1016/s1734-1140(09)70122-7

Cited by 53 publications

(36 citation statements)

References 15 publications

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“…However, our recent research showed the serum corticosterone level in mice did not increase after a 7-day intravenous injection of escin [13]. In another study, we further found escin to be a safe and potent anti-inflammatory drug with long effective anti-inflammation and without immunosuppression [14].…”

Section: Proofs For the Hypothesismentioning

confidence: 81%

Escin may exert a synergistic anti-inflammatory effect with glucocorticoids

Zhang¹,

Wang²,

Fan³

et al. 2010

Health

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Escin is a natural mixture of triterpenoid asponin isolated from the seed of the horse chestnut and demonstrates anti-oedematous and anti-inflammatory effects. As yet, the precise mechanisms by which escin exerts its antiinflammatory effects remain unclear. The data from current studies indicate that the anti-inflammatory properties of escin were attributed to its ability to reduce the adhesiveness of neutrophils and the associated release of inflammatory mediators; its ability to decrease histaminic and serotoninergic activities; its ability to inhibit phospholipase A 2 ; its ability to decrease nuclear factor-κ B activation and down-regulate the expression of tumor necrosis factor-α. All these effects are similar to glucocorticoids. Moreover, escin depends on adrenal glands to exert its anti-inflammatory effects. Also, our recent research showed that the serum corticosterone level in mice did not increase after a 7-day intravenous injection of escin. The results support the hypothesis that escin may exert a synergistic anti-inflammatory effect with glucocorticoids. Confirming this hypothesis will play a role in elucidating the anti-inflammatory mechanisms of escin.

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Section: Proofs For the Hypothesismentioning

confidence: 81%

Escin may exert a synergistic anti-inflammatory effect with glucocorticoids

Zhang¹,

Wang²,

Fan³

et al. 2010

Health

Self Cite

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“…Whole blood was assayed in duplicate for hemoglobin concentration by spectrophotometer (GBC, Cintra 10e). Red blood count (RBC) [20] was determined with an blood cell arithmometer (ABX Micros 60, France) and blood glucose (kit from Nanjing Jiancheng Inc, Nanjing, China) was determined by the spectrophotometer (GBC, Cintra 10e) [21] .…”

Section: Methodsmentioning

confidence: 99%

Living high training low induces physiological cardiac hypertrophy accompanied by down-regulation and redistribution of the renin-angiotensin system

et al. 2013

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Aim: Living high training low" (LHTL) is an exercise-training protocol that refers living in hypoxia stress and training at normal level of O 2 . In this study, we investigated whether LHTL caused physiological heart hypertrophy accompanied by changes of biomarkers in reninangiotensin system in rats. Methods: Adult male SD rats were randomly assigned into 4 groups, and trained on living low-sedentary (LLS, control), living lowtraining low (LLTL), living high-sedentary (LHS) and living high-training low (LHTL) protocols, respectively, for 4 weeks. Hematological parameters, hemodynamic measurement, heart hypertrophy and plasma angiotensin II (Ang II) level of the rats were measured. The gene and protein expression of angiotensin-converting enzyme (ACE), angiotensinogen (AGT) and angiotensin II receptor I (AT 1 ) in heart tissue was assessed using RT-PCR and immunohistochemistry, respectively. Results: LLTL, LHS and LHTL significantly improved cardiac function, increased hemoglobin concentration and RBC. At the molecular level, LLTL, LHS and LHTL significantly decreased the expression of ACE, AGT and AT 1 genes, but increased the expression of ACE and AT 1 proteins in heart tissue. Moreover, ACE and AT 1 protein expression was significantly increased in the endocardium, but unchanged in the epicardium. Conclusion: LHTL training protocol suppresses ACE, AGT and AT1 gene expression in heart tissue, but increases ACE and AT 1 protein expression specifically in the endocardium, suggesting that the physiological heart hypertrophy induced by LHTL is regulated by regionspecific expression of renin-angiotensin system components.

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“…Escin is a natural mixture of triterpene saponins, and has shown clinically significant anti-inflammatory activity postoperatively and in chronic venous insufficiency, haemorroids and traumatic brain edema. It mainly exerts its anti-inflammatory and anti-edematous effects through its anti-histamine and antiserotoninergic activities, and by reducing the adhesiveness and migration of neutrophils (6). The aim of the present study was to investigate the effect of escin on the inflammation induced by LPS in primary culture of hPDLs.…”

Section: Introductionmentioning

confidence: 98%

Escin inhibits lipopolysaccharide-induced inflammation in human periodontal ligament cells

Liu

Wang

Qiu

et al. 2012

Molecular Medicine Reports

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Abstract. Periodontitis is a chronic inflammatory disease associated with gram-negative subgingival microflora infection. Accumulating experimental evidence suggests that escin exerts anti-inflammatory and anti-edematous effects. This study was designed to investigate the in vitro effects of escin on the inflammatory reaction of human periodontal ligament cells (hPDLs). hPDLs were stimulated with lipopolysaccharide (LPS). The cells were treated with various concentrations of escin. The viability of hPDLs was evaluated using the MTT method. The expression of Toll-like receptor 2 (TLR2) in hPDLs and the levels of IL-1β, TNF-α and IL-6 in the supernatant were measured. Escin significantly attenuated LPS-induced cytotoxicity in a concentration-dependent manner in hPDLs. Treatment with escin partly blocked the expression of TLR2. Escin also lowered the increase of proinflammatory cytokines (IL-1β, TNF-α and IL-6) induced by LPS. The present findings show that escin exerts a protective effect against LPS-induced inflammation in hPDLs. It was also shown that escin is a promising medicine for the treatment of periodontitis.

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Effects of escin on acute inflammation and the immune system in mice

Cited by 53 publications

References 15 publications

Escin may exert a synergistic anti-inflammatory effect with glucocorticoids

Escin may exert a synergistic anti-inflammatory effect with glucocorticoids

Living high training low induces physiological cardiac hypertrophy accompanied by down-regulation and redistribution of the renin-angiotensin system

Escin inhibits lipopolysaccharide-induced inflammation in human periodontal ligament cells

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