Effects of Eriobotrya japonica Lindl. (Loquat) Leaf Ethanol Extract on Cholesterol and Antioxidative Activity in Rats Fed a High-Fat/High-Cholesterol Diet

Abstract

We investigated the effects of an ethanol extract of Eriobotrya japonica Lindl. (loquat) leaves (EJ) on the lipid metabolism of serum, liver, and adipose tissue, and antioxidative activity in rats fed a fat/cholesterol diet for four weeks. Male Sprague-Dawley rats weighing 207 g were divided into 4 groups: a normal diet group (N), a high-fat/high-cholesterol diet group (HFC), a high-fat/high-cholesterol diet group administered 200 mg/kg day EJ (HFC-EJL), and a high-fat/high-cholesterol diet group administered 400 mg/kg/day EJ (HFC-EJH). The serum ALT and AST activities of the EJ groups were lower than those of HFC group, but there was no significant change in serum ALP or LDH activities. The serum total and LDL-cholesterol, atherogenic index, and cardiac risk factor tended to be decreased in the EJ groups compared to the HFC group, while the serum HDL-cholesterol decreased in the HFC group and increased only minimally in the EJ groups. The total cholesterol in liver and mesenteric adipose tissues was lower in the EJ groups than in the HFC group. Triglycerides in the mesenteric and epididymal adipose tissues were lower in the EJ groups than in the HFC group. The liver GSH levels of the EJ groups were significantly lower than the HFC group. The liver TBARS content was significantly lower in the EJ groups than in the HFC group. These results suggest that EJ ethanol extract may improve the lipid metabolism of serum, liver, and adipose tissue and prevent oxidative stress by stimulating antioxidative systems in rats fed a high-fat/high-cholesterol diet.

Polyphenol-rich extract from loquat fruit peel prevents hyperlipidemia and hepato-nephrotoxicity in mice: in vivo study and in silico prediction of possible mechanisms involving identified polyphenols and/or their circulating metabolites

“…[59][60][61] As previously hypothesized, the protective effect of the peel extract could be due to the presence of phenolic compounds, which are known especially for their hypolipidemic, anti-oxidant and hepatoprotective activities. 2,15,16 Thus, after HPLC analysis, we realized that the studied extract contained five major phenolic compounds, namely, ferulic acid, caffeic acid, neochlorogenic acid, chlorogenic acid and quercetin. Furthermore, it appears that neochlorogenic acid is the most prevalent phenolic component, which is known in the literature for its interesting pharmacological activities.…”

“…12 To date, several scientific studies have investigated the biological properties of various parts of the loquat plant, including its antidiabetic, antihyperlipidemic, anti-obesity, hepatoprotective and antioxidant effects in different animal models. 11,[13][14][15][16] However, the protective effect of fruit peel against tyloxapol-induced hyperlipidemia and liver and kidney toxicity has not yet been studied.…”

Assessment of antioxidant activities of HeukHarang a novel Korean Lectuca sativa L.

“…This method can be used to obtain results in a short time. It can be applied to both hydrophobic and hydrophilic sample (Kim et al, 2019). ABTS free radial scavenging activities of HeukHarang and red lettuce extracts were compared.…”

The Efficacy of Eriobotryae Folium Pharmacopuncture on Local Fat of High Fat Diet Induced Obesity Mice※

“…그 주요 성분은 nerolidol, ferulic acid이며, 그 외에 ursolic acid, oleanolic acid, β-carotene, kaempherol, amygdalin, malic acid, citric acid, tannin 등이 함유되어 있으며 항당뇨, 항산화, 항염 증, 항암, 항균 효과, 항바이러스 효과가 있는 것으로 알려 져 있다. 또한 비파엽에 함유된 polyphenol, flavonoid 등의 생리활성 물질은 체지방형성을 억제하고, 체내 지질대사 개 선과 심혈관계 질환 예방에 효과가 있다는 보고가 있다 [10][11][12][13][14][15][16][17][18][19][20][21] . 5).…”