The Efficacy of Eriobotryae Folium Pharmacopuncture on Local Fat of High Fat Diet Induced Obesity Mice※

Abstract

Objectives : This study was designed to investigate the anti-obesity effects in local area adipose tissue using by pharmacopuncture of Eriobotryae Folium on mice fed high fat diet. Methods : Male ICR mouse were divided into three groups. Normal diet group (N), High-fat diet(HFD) group, HFD+E(pharmacopuncture of the Eriobotryae Folium) group for 8 weeks. HFD+E group was injected in the concentration of 50 mg/kg once a day for 4 weeks and every other day during the next 4 weeks. We measured body weight, food intake, absolute weight and relative weight in the liver and adipose tissue. Also, we analyzed hematological levels and histopathological changes on adipose tissue. Results : 1. We observed no difference in food intake among three groups.2. HFD+E group significantly decreased body weight gain and absolute weight and relative weight in the liver and adipose tissue compared with HFD group. 3. Blood AST and ALT were no differences among the experiment groups. However, HFD group was significantly increased higher TG, TC, HDL and LDL than in N group and HDL/LDL ratio was remarkably decreased. On the other hand, HFD+E group was significantly decreased in obesity markers and HDL/LDL ratio was remarkably increased. 4. Levels of adiponectin in serum of HFD+E group was remarkably increased compared with those of HFD group. 5. HFD group was significantly decreased compared with N group in adipocyte number. Compared with the HFD group, HFD+E group was displayed a significant increase by adipocyte number. Conclusions : We suggest that pharmacopuncture of the Leaves of Eriobotrya japonica can play the anti-obesity effects in local area adipose tissue.

Study of Latest Trend on Acupuncture for Obesity Treatment

“…The effects of a decrease in weight gain and a decrease in adipose tissue proliferation [ 25 , 26 ] were confirmed. In addition, there were studies confirming a decrease in adipocyte size and a decrease in plasma Triglycerides and Total-Cholesterol [ 27 , 28 ]. Kwon and Park [ 29 ] confirmed the antioxidant, pro-inflammatory and lipid lowering effects including Triglycerides and Total-Cholesterol.…”

“…As such, animal researches were conducted using pharmacopuncture in most cases, and there was an improvement in obesity index and in some researches reported there was no hepatotoxicity [ 21 , 28 , 33 ]. So it is judged to be the basis for efficacy and safety in clinical obesity treatment.…”

Trend of Pharmacopuncture Treatment on Obesity: Recent 10 Years

“…혈위는 인체와 상응하는 동물의 부위를 취혈하였다. 1) [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] . 21) , 반하추출물 약침 12) , 마황천오 약침 24) 이 사용되었다.…”

Effects of Loquat(Eriobotrya japonica Lindl.) Extracts in Different Aerial Components on Differentiation of 3T3-L1 Cells and Pig Preadipocytes

“…항비만 기능성 소재 개발 연구는 대부분 지방세포의 분화과정을 억제하 거나 지방분해를 촉진하는 소재를 탐색하는 방향으 로 진행되고 있다 (Kwon 2016;Song & Choi 2016). 최근에는 천연물에 함유된 phytochemical, 색소, 효소, 식이섬유소 등이 체지방 축적을 억제하 거나, 분해를 증가시켜 항비만 효과가 있다는 연구 (Choi et al 2010;Song et al 2013: Jeong et (Roh et al 2013). 비파 잎의 주요 성분은 sesquiterpene 배당체로 ferulic acid, nerolidol 등을 함유하고 있으며 (Lee et al 2004), triterpene 계열의 화합물로는 ursolic acid, oleanolic acid, maslinic acid, tormentic acid, hyptadienic acid 등을 함유하고 있는 것으로 보고 (Shimizu et al 1996; Taniguchi et al 2002)되었다.…”