Effects of environment pollution on the ocular surface

Jung, Se Ji; Mehta, Jodhbir S.; Tong, Louis

doi:10.1016/j.jtos.2018.03.001

Cited by 150 publications

(107 citation statements)

References 54 publications

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“…The effects of UPM for long-term application on various parts of the eye, including the cornea, the conjunctiva and the retina, were carefully investigated. As shown in several human studies, PM is harmful to the ocular surface and causes various discomforts, including presbyopia, instability of tear film, allergic conjunctivitis, toxicity, oxidative stress and inflammation [2,8,25,26]. These symptoms, such as dry eye, have also been reported in animal studies applying various types of PM to the eye [10,11,18].…”

Section: Discussionmentioning

confidence: 83%

Long-Term Exposure to Urban Particulate Matter on the Ocular Surface and the Incidence of Deleterious Changes in the Cornea, Conjunctiva and Retina in Rats

Kang

Choi

Jang

et al. 2020

IJMS

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We investigated the time-dependent deleterious ocular changes induced by urban particulate matter (UPM) in vitro and in vivo. UPM treatment decreased human corneal epithelial cell migration and survival. Fluorescein scores were consistently increased by UPM application for 16 weeks. One week of rest at 2 or 4 weeks led to a recovery trend, whereas two weeks of rest at 8 weeks induced no change. UPM treatment decreased the tear film break-up time at 2 weeks, which was thereafter maintained until 16 weeks. No changes were found after periods of rest. UPM-treated eyes exhibited greater corneal epithelium thickness than normal eyes at 2 weeks, which recovered to normal at 4 and 8 weeks and was significantly decreased at 16 weeks. Apoptotic cell number in the epithelium was increased at 2 weeks, which remained constant except at 8 weeks. IL-6 expression in the cornea of the right eye continually increased for 16 weeks, and significant recovery was only observed at 8 weeks after 2 weeks of rest. Ocular pressure was significantly increased in the right eye at 12 and 16 weeks. Topical UPM application to the eye induced deleterious changes to various closely related parts of the eye.

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Section: Discussionmentioning

confidence: 83%

Long-Term Exposure to Urban Particulate Matter on the Ocular Surface and the Incidence of Deleterious Changes in the Cornea, Conjunctiva and Retina in Rats

Kang

Choi

Jang

et al. 2020

IJMS

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“…Secondly, we were unable to assess the actual duration and concentration of air pollution exposure in our study participants. Measurement of the PM 2.5 and NO 2 concentration, along with a range of other ocular surface disorder diagnostic tests similar to that of few previous studies 20 , would have provided us a better understanding of the association between air pollution and ocular surface disorders. Thirdly, a comparison with a control group of individuals who were not exposed to such level of air pollution or exposed to a lower level of air pollution would have allowed us to confirm that the ocular symptoms were primarily due to air pollution.…”

Section: Discussionmentioning

confidence: 93%

Ocular surface symptoms among individuals exposed to ambient levels of traffic derived air pollution – a cross-sectional study

et al. 2018

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Background: The ocular surface is separated by a thin layer of tear film from outdoor air pollutants making individuals exposed to outdoor air pollution prone to various ocular surface disorders. The aim of this study was to determine the magnitude of ocular surface disorders symptoms among traffic police officers of Kathmandu, Nepal. Methods: Two hundred traffic police officers working at different traffic police office branches of Kathmandu, Nepal were invited to the police headquarters for eye and vision examination. Among them, 91 individuals (95% males) completed the ocular surface disease index (OSDI) questionnaire and underwent Schirmer’s I tear test. Results: Symptoms of ocular surface disorders were reported by over 80% of the individuals. Approximately two-fifths of the individuals (38%) reported severe symptoms. Only 17% of the individuals’ tear secretion was found to be below normal using the Schirmer’s tear test. No significant association was observed between the OSDI score and Schirmer’s tear test scores (r = 0.008, p = 0.94). A weak but significant relationship was observed between the OSDI score and job duration (r=0.21,p = 0.04). Individual exposed to outdoor air pollution for more than 10 years had higher odds of reporting ocular surface complaints as compared to those who were exposed for less than 10 years (OR = 3.94, p = 0.02). Conclusion: Ocular surface disorder symptoms are common among traffic police officers of Kathmandu, Nepal. The duration of exposure appears to significantly contribute to the increased symptoms in this exposed population.

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“…The DE incidence increased gradually due to environmental pollution and the overuse of visual display terminal in recent years. [ 39 , 40 ] AC treatment for DE attracted increasing attention of scholars, considering its benefit of simple operation, low price, and fewer side effects. Although the mechanism of AC for DE is still not completely clarified, an experimental study has revealed that AC could reduce the concentration of proinflammatory cytokines (TNF-α, IL-4, IL-12) in tears.…”

Section: Discussionmentioning

confidence: 99%

Acupuncture for the treatment of dry eye

et al. 2020

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Background: As a common ophthalmic disease, dry eye (DE) may bring several adverse effects on the quality of life for patients. In recent years, Acupuncture (AC) is becoming increasingly popular for treating DE. Thus, we conceived this systematic review aims to evaluate the effectiveness and safety of AC for DE objectively. Methods: The search results are restricted to randomized controlled trials and human studies. We will establish the inclusion criteria through discussion and design a detailed literature search strategy for each database. Articles are searched from 4 English databases (the Cochrane Library, PubMed, Web of Science, and EMBASE) and 4 Chinese databases (Wangfang, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, and Chinese scientific and technical journals database). The relevant studies published from the date of database inception until January 2020 will be collected. We will also search (International Clinical Trials Registry Platform), PROSPERO, and potential gray literature. Two reviewers independently perform literature screening, information extraction, and assessment of study quality. The outcome measures include primary outcome measures (Schirmer I test and break-up time), secondary outcome measures (Ocular Surface Disease Index, corneal fluorescein staining, and tear osmolarity), and safety outcome measures. Assessment of bias risk and data processing are performed using RevMan 5.3 software ( the Nordic Cochrane Centre, Copenhagen, Denmark). Results: We will evaluate the curative effect of AC for DE comprehensively based on multiple outcome measures. Conclusion: This systematic review will provide evidence for the effectiveness and safety of AC in the treatment of DE. PROSPERO number: CRD42019144790

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Effects of environment pollution on the ocular surface

Cited by 150 publications

References 54 publications

Long-Term Exposure to Urban Particulate Matter on the Ocular Surface and the Incidence of Deleterious Changes in the Cornea, Conjunctiva and Retina in Rats

Long-Term Exposure to Urban Particulate Matter on the Ocular Surface and the Incidence of Deleterious Changes in the Cornea, Conjunctiva and Retina in Rats

Ocular surface symptoms among individuals exposed to ambient levels of traffic derived air pollution – a cross-sectional study

Acupuncture for the treatment of dry eye

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