Effects of endotoxic shock on neuronal NOS and calcium transients in rat cardiac myocytes

SERCA Cys674sulphonylation and inhibition of L-type Ca2+influx contribute to cardiac dysfunction in endotoxemic mice, independent of cGMP synthesis

“…SERCA inhibition has been previously demonstrated in two different rat (7,35,41) and dog (36) models of SIC. From a methodological point of view, it is important to point out that, in our study, SERCA activity was measured in intact cells, as Ca 2ϩ transient Ca (Fig.…”

Differences in the Effect of Angiotensin-converting Enzyme Inhibitors on the Rate of Endothelial Cell Apoptosis: In Vitro and In Vivo Studies

“…LPS also regulates The effects of different ACE inhibitors on SBP are reported as a percentage pressure reduction with respect to basal evaluation. Data are expressed as means±SD [32]. There is a downregulation of both the endothelial and neuronal NOS isoforms concomitant to an increase in the inducible NOS isoform [32].…”

“…Data are expressed as means±SD [32]. There is a downregulation of both the endothelial and neuronal NOS isoforms concomitant to an increase in the inducible NOS isoform [32]. This could account for either antiapoptotic or proapoptotic activity [33,34].…”

Cardiovascular and pulmonary effects of NOS inhibition in endotoxemic conscious rats subjected to swimming training

“…In this respect, it has been noted that many compounds that either stimulate the catalytic activity of cNOS, or upregulate the expression of the enzyme, are reported to act as downregulators, or suppressors, of iNOS expression (Colasanti and Suzuki, 2000;Mariotto et al, 2004;Persichini et al, 2006). In a recent study (Comini et al, 2005), it was observed that nNOS and eNOS in cardiac myocytes were downregulated in response to LPS treatment, while iNOS was upregulated. The cytosolic calcium seems to be affected by LPS, but probably not through endogenous NO production.…”