Effects of EMD in combination with bone swaging and calcium phosphate bone cement on periodontal regeneration in one‐wall intrabony defects in dogs

Shirakata, Yoshinori; Yoshimoto, Takehiko; Takeuchi, Naoshi; Taniyama, Katsuyoshi; Noguchi, Kazuyuki

doi:10.1111/j.1600-0765.2012.01499.x

Cited by 9 publications

(10 citation statements)

References 31 publications

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“…[ 15 18 ] However, in the study, alveolar bone and cementum formation almost reached 64–79% of the height of defect and 33–41% bone area formation (not including the residual ABB granules) in the ABB + CM groups. Although the 1-wall intrabony defect size (7 mm × 4 mm) was found healing within an 8-week period in this study, which indicated greater challenge to spontaneous healing than the generally reported 1-wall intrabony defects (4 mm × 5 mm or 3 mm × 5 mm) within an 8- or 12-week,[ 19 20 ] ABB + CM group exhibited more bone regeneration (71.38% on average in height) than those reported only with grafts (36.5–60.0% in newly formed bone height)[ 19 21 22 ] and even than that using grafts combined with cells or growth factors (31–71% in newly formed bone height). [ 23 24 ] In addition, treatment with ABB + CM did not show less periodontal regeneration in 1-wall intrabony defects than that in the 3-wall intrabony defect within the limits of this study.…”

Section: Discussionmentioning

confidence: 56%

Comparison of Different Periodontal Healing of Critical Size Noncontained and Contained Intrabony Defects in Beagles

Zang

Kang

et al. 2017

Chinese Medical Journal

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Background:Regenerative techniques help promote the formation of new attachment and bone filling in periodontal defects. However, the dimensions of intraosseous defects are a key determinant of periodontal regeneration outcomes. In this study, we evaluated the efficacy of use of anorganic bovine bone (ABB) graft in combination with collagen membrane (CM), to facilitate healing of noncontained (1-wall) and contained (3-wall) critical size periodontal defects.Methods:The study began on March 2013, and was completed on May 2014. One-wall (7 mm × 4 mm) and 3-wall (5 mm × 4 mm) intrabony periodontal defects were surgically created bilaterally in the mandibular third premolars and first molars in eight beagles. The defects were treated with ABB in combination with CM (ABB + CM group) or open flap debridement (OFD group). The animals were euthanized at 8-week postsurgery for histological analysis. Two independent Student's t-tests (1-wall [ABB + CM] vs. 1-wall [OFD] and 3-wall [ABB + CM] vs. 3-wall [OFD]) were used to assess between-group differences.Results:The mean new bone height in both 1- and 3-wall intrabony defects in the ABB + CM group was significantly greater than that in the OFD group (1-wall: 4.99 ± 0.70 mm vs. 3.01 ± 0.37 mm, P < 0.05; 3-wall: 3.11 ± 0.59 mm vs. 2.08 ± 0.24 mm, P < 0.05). The mean new cementum in 1-wall intrabony defects in the ABB + CM group was significantly greater than that in their counterparts in the OFD group (5.08 ± 0.68 mm vs. 1.16 ± 0.38 mm; P < 0.05). Likewise, only the 1-wall intrabony defect model showed a significant difference with respect to junctional epithelium between ABB + CM and OFD groups (0.67 ± 0.23 mm vs. 1.12 ± 0.28 mm, P < 0.05).Conclusions:One-wall intrabony defects treated with ABB and CM did not show less periodontal regeneration than that in 3-wall intrabony defect. The noncontained 1-wall intrabony defect might be a more discriminative defect model for further research into periodontal regeneration.

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Section: Discussionmentioning

confidence: 56%

Comparison of Different Periodontal Healing of Critical Size Noncontained and Contained Intrabony Defects in Beagles

Zang

Kang

et al. 2017

Chinese Medical Journal

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“…However, Zetterstrom et al and Hagenaars et al reported no differences in pacients' perceptions and postsurgical healing between surgeries with EMD and flap operations [16][17][18]. Saito et al in a study regarding the treatment of periodontal defects with enamel matrix derivative, showed after three to six months that periodontal surgery with EMD results in a clinically relevant reduction in probing depth and a gain in clinical attachment [19][20][21][22].…”

Section: Discussionmentioning

confidence: 99%

Clinical Outcomes after Regenerative Periodontal Therapy with Emdogain

Bereşescu

Ormenișan

Székely

et al. 2017

Acta Medica Marisiensis

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Objective: Regeneration is defined as a reconstruction of a lost part of the body in such a way that the structure and function of the lost tissue are completely restored. The aim of this study is to compare the clinical outcomes of intrabony defects treatment using regenerative periodontal therapy with enamel matrix proteins (Emdogain, EMD) with a control group. Methods: Ten patients with chronic periodontitis were included in this randomized, controlled clinical study. Two groups received conservative periodontal therapy. In the test group, different teeth received regenerative treatment with EMD. In the control group teeth received solely conservative periodontal therapy. Pocket depth probing (PD) and bone reduction (based on X rays) were registered at baseline and after eight months in both groups. In the control group Results: Both groups showed a significant reduction of PD. The teeth treated with EMD showed a significant attachment gain. Within the test group, the radiographic examination of the teeth treated with EMD showed no significant change, whereas the teeth in the control group showed significant bone reduction. Conclusions: Intrabony defects in teeth treaded with EMD exhibit a substantially higher gain in clinical attachment and defect filling. The use of EMD in dental practice can prevent further bone loss.

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“…These defects were created with trephine burs size 4 under copious amounts of saline solution irrigation. The bone obtained with intrabone marrow penetration was used in treatment as the source of autogenous bone graft (10) . Experimental periodontitis associated with one wall osseous defect was induced on the premolars of each quadrant of both jaw (11).…”

Section: Surgical Proceduresmentioning

confidence: 99%

Evaluation of autogenous Bone Graft with or without Intra-Marrow Penetration in Treating One Osseous Wall Defects: An experimental study.

2021

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Purpose:The study was designed to assess the autogenous bone grafting (ABG) alone or in combination with intra-marrow penetration (IMP) in treating one osseous wall defects in dog model. Material and methods: This study was conducted using 8 Beagle dogs that were divided randomly into two groups: Group I: received open flap debridement with autogenous bone graft, Group П: received open flap debridement with autogenous bone graft and IMP. Each animal received two treatment modalities, one for each jaw. Each jaw was divided into two halves (right and left). The surgery intervention was performed at base line in the left side. The right side received the same treatment after 6 weeks. All experimental defects were followed up through histological analysis. Results: Histomorphometric study presented significantly better bone neogenesis within both groups at 14, 60 days. The total area percent of new bone formed in group I was 38.46+7.71% while it was 33.17+7.3% in group II with non-significant variance between test groups throughout the study intervals. Conclusion:The regenerative therapy using either autogenous bone graft alone or with IMP showed an improvement in the management outcome of one osseous wall defects.

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Effects of EMD in combination with bone swaging and calcium phosphate bone cement on periodontal regeneration in one‐wall intrabony defects in dogs

Abstract: These results indicate that treatment with EMD + BS + CPC promotes favorable periodontal healing in one-wall intrabony defects in dogs.

Cited by 9 publications

References 31 publications

Comparison of Different Periodontal Healing of Critical Size Noncontained and Contained Intrabony Defects in Beagles

Comparison of Different Periodontal Healing of Critical Size Noncontained and Contained Intrabony Defects in Beagles

Clinical Outcomes after Regenerative Periodontal Therapy with Emdogain

Evaluation of autogenous Bone Graft with or without Intra-Marrow Penetration in Treating One Osseous Wall Defects: An experimental study.

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