Effects of electrostatic charge on the pulmonary deposition of mineral dust aerosols inhaled by rats

Jones, A. D.; Johnston, A.M.; McMillan, C.H.

doi:10.1016/0021-8502(88)90208-x

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…Compared with drag and gravitational forces, electrostatic effects on charged inertial particle transport in the lungs are much less understood. Aerosol inhalation studies of charged aerosols have been conducted on human and animal subjects 22–24. Related theoretical studies of this subject have mainly focused on charged submicron particles where the continuum approach could be applied in the context of a cylindrical geometry 25–28…”

Section: Introductionmentioning

confidence: 99%

Electrostatic effects on inertial particle transport in bifurcated tubes

et al. 2009

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Most aerosols found naturally in the ambient environment or those dispersed from artificial devices such as dry powder inhalers, are electrically charged. It is known that a strong electrostatic charge on aerosols can result in transport behavior dramatically different from that of uncharged aerosols, even in the absence of an external electric field. In the present work, we study pneumatic transport of corona‐charged particles in bifurcated tubes. This is accomplished by tracking the motion of discrete particles numerically under the influence of drag, gravitational, and electrostatic forces. The model aerosol is fly ash powder, whose size and charge distributions have been determined experimentally. The electrical mobility of the charged particle cloud is modeled through coulombic interactions between discrete point charges. For the case of polydispersed particles electrically charged across a distribution, the deposition efficiency was found to be greater than what is indicated by the mean charge and size. In particular, use of negatively charged fly ash powder of mean size of 2 μm and mean charge of −1.5 C/kg led to significant increase in deposition efficiency (∼29%) compared with uncharged fly ash powder of the same size distribution (∼8%). Analysis of particle residence times suggests significant interaction between electrical and drag forces. These findings could have implications for pneumatic powder conveying or pulmonary drug delivery applications. © 2009 American Institute of Chemical Engineers AIChE J, 2009

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Section: Introductionmentioning

confidence: 99%

Electrostatic effects on inertial particle transport in bifurcated tubes

et al. 2009

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The Influence of Charge on the Deposition Behavior of Aerosol Particles with Emphasis on Singly Charged Nanometer Sized Particles

Cohen

Xiong

1996

Aerosol Inhalation: Recent Research Frontiers

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Estimation of the Deposition of Aerosolized Drugs in the Human Respiratory Tract Due to Hygroscopic Growth

Ferron¹,

Oberdörster²,

Henneberg³

1989

Journal of Aerosol Medicine

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Hygroscopic aerosol particles will grow in the human respiratory tract due to the nearly saturated air. A calculation method had been developed previously to estimate the growth and the deposition in the human respiratory tract of salt particles.This method is adapted here to estimate the growth and the deposition of particles of three drugs during respiration. The relative growth of drug particles is comparable to the growth of salt particles, where different drug particles change their size by a factor of 2.2-3.5, and salt particles by a factor of 2.0-4.4. Likewise, the deposition in the bronchial and pulmonary regions is enhanced for particles with initial sizes in the range of 0.3-5 urn for both the drug and salt particles. The increase in deposition is about a factor of 2 for particles with initial sizes between 0.5-2 urn. Also, the maximum values for deposition in the bronchial and pulmonary regions at initial particle sizes between 2-4 urn are increased by up to 20% compared to the values for stable particles. An equation is proposed to estimate the deposition of an arbitrary aerosolized drug particle in the bronchial and pulmonary regions.We conclude that the hygroscopicity of drug particles is an important factor for estimating their deposition in the human respiratory tract.

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Effects of electrostatic charge on the pulmonary deposition of mineral dust aerosols inhaled by rats

Cited by 3 publications

References 18 publications

Electrostatic effects on inertial particle transport in bifurcated tubes

Electrostatic effects on inertial particle transport in bifurcated tubes

The Influence of Charge on the Deposition Behavior of Aerosol Particles with Emphasis on Singly Charged Nanometer Sized Particles

Estimation of the Deposition of Aerosolized Drugs in the Human Respiratory Tract Due to Hygroscopic Growth

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