Effects of electroconvulsive shock on food and water intake in the rat

Prewett, Michael J.; Milner, Joel S.

doi:10.1016/0031-9384(77)90350-x

Cited by 10 publications

(6 citation statements)

References 13 publications

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“…Prewett and Milner (1977) found a 15% decrease in food intake following a single ECS treatment, whereas the present study showed a 36% decrease following five ECS treatments. The additional decrement in water intake following multiple shocks was not as great as that observed for food intake.…”

Section: Resultscontrasting

confidence: 89%

“…The decrease in water intake with a subsequent three-day recovery period observed by Prewett and Milner (1977) is supported by biochemical changes that occur following administration of ECS. Acetylcholinesterase (AChE), a cholinergic antagonist, appears to increase following one ECS and, subsequently, returns to baseline after 3 days (Adams, Hoblit, & Sutker, 1969).…”

mentioning

confidence: 79%

“…Acetylcholinesterase (AChE), a cholinergic antagonist, appears to increase following one ECS and, subsequently, returns to baseline after 3 days (Adams, Hoblit, & Sutker, 1969). The decrease in food intake reported by Prewett and Milner (1977) can also be correlated with biochemical changes in the brain. ECS is reported to produce changes in the adrenergic system, albeit the nature and direction of the changes remain unclear (Schildkraut & Draskoczy, 1974).…”

mentioning

confidence: 88%

“…The present study was designed to supplement and extend the initial findings of Prewett and Milner (1977) by investigating the effects of multiple ECS treatments on food and water intake in the rat. The time required for recovery from multiple ECS treatment was also investigated.…”

mentioning

confidence: 99%

“…Investigators (Prewett & Milner, 1977) have studied the effects of electroconvulsive shock (ECS) on feeding and drinking behavior in the rat. They report a single ECS produces a significant decrease in both food and water intake.…”

mentioning

confidence: 99%

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Multiple electroconvulsive shocks and feeding and drinking behavior in the rat

Prewett

Allen

Milner

1978

Bull. Psychon. Soc.

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Daily food and water intakes of 22 male rats were measured during a 4-week habituation period. After habituation, animals were administered a series of five electroconvulsive shock (ECS) treatments, one per day for 5 days. Daily food and water intake measurements were continued during ECS treatments and for 11 days following the last shock. Comparing the last preand the first post-ECS treatment days, a significant decrease in both food and water intake was found. Food and water intakes required 8 to 10 days to return to pre-ECS treatment levels.

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Section: Resultscontrasting

confidence: 89%

mentioning

confidence: 79%

mentioning

confidence: 88%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Multiple electroconvulsive shocks and feeding and drinking behavior in the rat

Prewett

Allen

Milner

1978

Bull. Psychon. Soc.

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Does electroconvulsive shock therapy work through opioid mechanisms?

Jackson¹,

Nutt²

1990

Human Psychopharmacology

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It is now well-established that electroconvulsive shock (ECS) is the most effective treatment for severe depression. Over the past two decades a great deal of new information has been obtained regarding its neuropharmacological basis. The present review examines evidence that the behavioural and mood-elevating actions of ECS are mediated through changes in the function of opioid receptors or their endogenous transmitters. The recent discovery of stable, non-peptide ligands for the K-and &receptor subtypes are detailed, and the prospects for a new phase of research in this area are expounded.

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