Effects of electroacupuncture at Guanyuan (CV 4) or Sanyinjiao (SP 6) on hypothalamus-pituitary-ovary axis and spatial learning and memory in female SAMP8 mice

Wang, Jing; Cheng, Kai Yuan; Zhuo, Qin; Wang, Yanping; Lijing, Zhai; You, Min; Juanjiao, Wu

doi:10.1016/s0254-6272(17)30032-8

Cited by 13 publications

(4 citation statements)

References 5 publications

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“…Wang [ 30 ] reported that moxibustion on CV 4 could partly improve learning and memory in AD rats, possibly through inhibition of hippocampal GSK-3 β activities and downregulating the phosphorylation levels of Tau protein site Ser396/Thr231. Another study suggested that electroacupuncture at CV 4 could improve spatial learning and memory ability in female SAMP8 mice through regulating HPO axis [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Moxibustion on Behavioral Changes and Expression of APP and BACE1 in Hippocampus of SAMP8 Mice

Yang

Wang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Objective. To observe the effect of moxibustion on cognitive function of aging mice, to observe the effect of moxibustion on protein and gene expression of APP metabolism pathway, and to explore the mechanism of action in moxibustion. Methods. 24 SAMP8 were randomly divided into 2 groups (12 in each group): moxibustion group and model group. 12 SAMR1 mice were used as blank controls. Mice in the moxibustion group were treated with moxibustion for 8 weeks, 10 minutes each time, 5 times a week, and for a total of 8 weeks. The model group and the blank group were treated with sham-moxibustion. Behavior tests were used to detect the learning and memory ability of each group of mice. Immunohistochemical, western blot, and RT-PCR were used to detect the protein and mRNA expression of APP and BACE1. Furthermore, the expressions of miR-29 and miR-101 were observed by RT-PCR method to explore the mechanism of moxibustion at the genetic level. Results. In this study, relative to normal mice, we found that aging mice showed behavioral changes consistent with the onset of AD. However, moxibustion interventions were able to mitigate these effects to some degree in aging mice. In addition, moxibustion was proved to regulate APP metabolism pathway at protein and gene level through molecular biology tests. Conclusion. The data suggest that the effect of moxibustion intervention on cognitive function in aging mice is related to the regulation of genes and proteins involved in APP metabolism pathway; this may be a potential target for treating Alzheimer’s disease.

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Section: Discussionmentioning

confidence: 99%

Effect of Moxibustion on Behavioral Changes and Expression of APP and BACE1 in Hippocampus of SAMP8 Mice

Yang

Wang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…Modern research shows that the incidence of PMS may be related to abnormal neural activity in the brain's default mode network (DMN) [39, 40]; thus, acupuncture treatment at SP6 can regulate abnormal nerve activity in the DMN area [41]. In addition, animal studies have shown that acupuncture at SP6 and RN4 can regulate the hormone balance of the hypothalamic-pituitary-ovarian axis [42]. The other two acupoints with higher frequency are LR3 and Ren4.…”

Section: Discussionmentioning

confidence: 99%

Acupuncture for Premenstrual Syndrome at Different Intervention Time: A Systemic Review and Meta-Analysis

Zhang

Cao²,

Yao

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Background. Premenstrual syndrome (PMS) is one of the most common gynecological conditions with no standard modern therapeutic schedule. Some studies have reported the effects of acupuncture in treating PMS, but the intervention time varies. This review evaluated the efficacy of acupuncture for patients with PMS and the appropriate time to initiate acupuncture therapy. The review has been registered on the “PROSPERO” website; the registration number is CRD42018109724. Methods. A comprehensive literature search was performed on 9 electronic databases from the time of inception to September 2018. RCTs studies on acupuncture for PMS compared with medication, sham acupuncture, or no treatment were included. Statistical analysis and investigation of heterogeneity source were carried out using RevMan5. 3. Results. A total of 15 studies, comprising of 1103 cases, were included. Overall, acupuncture significantly increased the effective rate of PMS compared with medicine and sham acupuncture. Subgroup analyses showed no significant difference among different intervention time to start acupuncture treatment. Among the acupoints involved in the treatment of PMS, SP6, LR3, and RN4 were the most commonly used. Conclusions. The current meta-analysis reveals that acupuncture leads to better effective rate, but the intervention time has no significant effect on the efficacy of acupuncture treatment for PMS. SP6, LR3, and RN4 are the most commonly used acupoints in treating PMS. However, large-scale, case-control studies with rigorous designs are required to provide more accurate evidence.

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“…Moreover, recent studies found that estrogen also have roles in preventing AD, and the mechanism might be related to the effects of estrogen on central BDNF and neurotransmitter. EA at Guanyuan (CV4) and SP6 can increase the level of estradiol (E2) in the hypothalamus-pituitary-ovary (HPO) axis to improve spatial learning and memory of female SAMP8 mice [57]. Recently, the regulatory effect of acupuncture on nerve regeneration also received some attention.…”

Section: Neuron Loss and Degenerationmentioning

confidence: 99%

The Effectiveness and Mechanisms of Acupuncture in Treating Alzheimer's Disease

Kang

Zhao

et al. 2023

Preprint

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Alzheimer's disease (AD), which mainly manifested by cognitive decline, affects millions of elderly people around the world. With the global aging continues to accelerate, the incidence of AD is also increasing year by year. The chronic, persistent, and irreversible decline of learning and memory ability of AD brings serious harm and economic burden to families and society. Because of its complex of pathogenesis, there is still a lack of effective treatment for AD. Acupuncture, as one of the complementary and alternative therapies, has provided a promising avenue for the treatment of AD. This study comprehensively reviews literature from the last ten years, showing that acupuncture indeed exerts strong beneficial effects on AD. Acupuncture can regulate the species and structure of the intestinal flora, repair the intestinal barrier and the brain blood barrier, prevent inflammatory cytokines and harmful substances in the intestine from entering the blood and brain to improve the cognitive impairment of AD. In addition to this, acupuncture can treat AD by regulating Aβ deposition (including inhibiting Aβ production and promoting Aβ clearance), inhibiting tau protein phosphorylation, improving the structure and function of neurons and synapses, promoting nerve regeneration, relieving chronic neuroinflammation, regulating energy metabolism and cerebral blood flow of the brain, etc. It is worth noting that the effect of acupuncture on AD is related to the selections of acupoints, the form and frequency of acupuncture, etc. Some special acupuncture methods, such as Sanjiao acupuncture and "olfactory three-needle" therapy, also provide new perspectives for AD. The therapeutic effect and potential mechanism of acupuncture on AD summarized in this study provide scientific and reliable evidence for acupuncture application for AD.

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Effects of electroacupuncture at Guanyuan (CV 4) or Sanyinjiao (SP 6) on hypothalamus-pituitary-ovary axis and spatial learning and memory in female SAMP8 mice

Cited by 13 publications

References 5 publications

Effect of Moxibustion on Behavioral Changes and Expression of APP and BACE1 in Hippocampus of SAMP8 Mice

Effect of Moxibustion on Behavioral Changes and Expression of APP and BACE1 in Hippocampus of SAMP8 Mice

Acupuncture for Premenstrual Syndrome at Different Intervention Time: A Systemic Review and Meta-Analysis

The Effectiveness and Mechanisms of Acupuncture in Treating Alzheimer's Disease

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