Effects of Eicosapentaenoic Acid Treatment on Epicardial and Abdominal Visceral Adipose Tissue Volumes in Patients with Coronary Artery Disease

Sato, Takao; Kameyama, Tomoki; Ohori, Takashi; Matsuki, Akira; Inoue, Hiroshi

doi:10.5551/jat.23390

Cited by 18 publications

(9 citation statements)

References 54 publications

(51 reference statements)

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“…For practical reasons we did not measure inflammatory responses in visceral fat, a depot known to be inherently more immune-cell infiltrated than subcutaneous fat. Some investigators have reported positive effects of v-3 fatty acid supplements on visceral fat (46,47), and others have noted that greater self-reported v-3 fatty acid intakes are negatively associated with visceral fat and percentage of body fat in healthy children (48). We cannot know whether there might have been a beneficial effect of v-3 fatty acids on visceral fat inflammation in our participants, but if there was it did not improve inflammatory markers (26) or insulin sensitivity.…”

Section: Discussioncontrasting

confidence: 40%

Very-long-chain ω-3 fatty acid supplements and adipose tissue functions: a randomized controlled trial

Hames¹,

Morgan‐Bathke²,

Harteneck³

et al. 2017

The American Journal of Clinical Nutrition

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Section: Discussioncontrasting

confidence: 40%

Very-long-chain ω-3 fatty acid supplements and adipose tissue functions: a randomized controlled trial

Hames¹,

Morgan‐Bathke²,

Harteneck³

et al. 2017

The American Journal of Clinical Nutrition

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“…The superior border for measuring the EAT volume was set at the lower surface of the left pulmonary artery origin. The inferior border for the measurement was set at the left ventricular apex 19) . The EAT area was calculated by tracing an ROI that included the heart and EAT.…”

Section: Eat Volume Measurement With Multislice Ctmentioning

confidence: 99%

The Effect of Dapagliflozin Treatment on Epicardial Adipose Tissue Volume and P-Wave Indices: An Ad-hoc Analysis of The Previous Randomized Clinical Trial

Sato

Aizawa

Yuasa

et al. 2020

JAT

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Aim: Epicardial adipose tissue (EAT) may be associated with arrhythmogenesis. P-wave indices such as P-wave dispersion and P-wave variation indicated a slowed conduction velocity within the atria. This study investigated the effect of dapagliflozin on EAT volume and P-wave indices.Methods: In the present ad hoc analysis, 35 patients with type 2 diabetes mellitus and coronary artery disease were classified into dapagliflozin group (n 18) and conventional treatment group (n 17). At baseline, EAT volume, HbA1c and plasma level of tumor necrotic factor-(TNF-) levels, echocardiography, and 12-lead electrocardiogram (ECG) were performed. EAT volume was measured using computed tomography. Using 12-lead ECG, P-wave indices were measured. dapagliflozin group only (-9.2 8.7 vs. 5.9 19.9 ms, p 0.01; -3.5 3.5 vs. 1.7 5.9 ms, p 0.01). The change in P-wave dispersion correlated with changes in EAT volume and plasma level of TNF-. In multivariate analysis, the change in EAT volume was an independent determinant of the change in P-wave dispersion. Conclusion: Dapagliflozin reduced plasma level of TNF-, EAT volume, and P-wave indices, such as P-wave dispersion. The changes in P-wave indices were especially associated with changes in EAT volume. The number and date of registration: UMIN000035660, 24/Jan/2019 Results: At baseline, EAT volumes in the dapagliflozin and conventional treatment groups were 113 20 and 110 27 cm 3 , respectively. Not only HbA1c and plasma level of TNF-but also echocardiography findings including left atrial dimension and P-wave indices were comparable between the two groups. After 6 months, plasma level of TNFas well as EAT volume significantly decreased in the dapagliflozin group only. P-wave dispersion and P-wave variation significantly decreased in the

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“…CT is the most frequently applied imaging technique to identify and measure the volume and thickness of EAT in clinical practice . With the high spatial resolution and axial scan, EAT could be easily distinguished from myocardium and paracardial adipose tissue particularly after application of iodine contrast agent . However, the application of CT is limited due to exposure of ionizing radiation especially when frequent assessment is needed (Figure ).…”

Section: The Link Between Af Obesity and Adipose Tissuementioning

confidence: 99%

Epicardial adipose tissue and atrial fibrillation: Possible mechanisms, potential therapies, and future directions

Zhou

Wang

Chen

et al. 2019

Pacing Clinical Electrophis

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Obesity plays an important role in the pathogenesis of atrial fibrillation (AF). Recently, rather than general fat distribution, epicardial adipose tissue (EAT) gains a growing concern. EAT is the local adipose deposition between myocardium and pericardium. Accumulated evidence revealed several distinguishing characteristics of EAT. It lies contiguously with the myocardium and could infiltration into myocardium, actively secrets cytokines and adipokines mediating inflammation or remodeling, and contains abundant ganglionated plexi. Clinical research also found EAT may be an independent risk factor of AF. Volume or thickness of EAT measured on CT or MRI could be applied as a predictor of presence, severity, and recurrence of AF. Some drugs, like antidiabetic drugs and lipid-lowing drugs, show ability to reduce EAT. Additional surgical ablation of EAT was also proved that it could improve outcome of pulmonary vein isolation for AF. In present review, we summarize recent epidemic, biological, and clinical findings about EAT and its possible role in AF. K E Y W O R D S atrial fibrillation, epicardial adipose tissue, mechanisms, therapies 1 2 THE LINK BETWEEN AF, OBESITY, AND ADIPOSE TISSUE Obesity and AFObesity is an already recognized risk factor of AF. 5,6 It is usually assessed by several indicators, such as body mass index (BMI), waist circumference, waist to hip ratio, and body fat rate. Compared with nonobese people, obese individuals possess higher probability (49%) of suffering AF, which may be associated with atrial enlargement, ventricular diastolic dysfunction, and ectopic fat depot increase. 5 Furthermore, previous literature showed that every 5 kg/m 2 increase in BMI could increase about 10-30% higher risks of AF, and also indicated that every 1 kg/m 2 reduction in BMI was associated with a significant 7% reduction in the risk of AF. 7 These pieces of evidence support that obesity is closely associated with AF occurrence. However, in general, the indicators to measure obesity, such as BMI, are relatively rough to reflect excess adipose; and individuals with similar BMI may have different risks of AF. More precise measurements are needed to predict the occurrence and development of AF.

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Effects of Eicosapentaenoic Acid Treatment on Epicardial and Abdominal Visceral Adipose Tissue Volumes in Patients with Coronary Artery Disease

Cited by 18 publications

References 54 publications

Very-long-chain ω-3 fatty acid supplements and adipose tissue functions: a randomized controlled trial

Very-long-chain ω-3 fatty acid supplements and adipose tissue functions: a randomized controlled trial

The Effect of Dapagliflozin Treatment on Epicardial Adipose Tissue Volume and P-Wave Indices: An Ad-hoc Analysis of The Previous Randomized Clinical Trial

Epicardial adipose tissue and atrial fibrillation: Possible mechanisms, potential therapies, and future directions

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