Effects of Eicosapentaenoic Acid on Tumour Growth and Cachexia in Mouse Colon Cancer1

Tisdale, Michael J.; Beck, S. A.; Hudson, Elizabeth

doi:10.1159/000423999

Cited by 3 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, these fatty acids have also been involved in retarding the appearance of cancer-associated cachexia. 7 Epidemiological studies involving Mediterranean countries strongly suggest that the olive-oil rich diet decreases the risk of both coronary heart disease and certain types of cancer. [8][9][10] In fact, although it is well established in laboratory animal models that high-fat diets promote the development of different types of tumor (as previously commented), a very high-fat diet containing mainly oleic acid is unable to promote tumorigenesis.…”

Section: P O L Y U N S a T U R A T E D N -3 F A T T Y A C I D Smentioning

confidence: 99%

Prevention of cancer and cardiovascular diseases: A common strategy?

et al. 1998

View full text Add to dashboard Cite

Section: P O L Y U N S a T U R A T E D N -3 F A T T Y A C I D Smentioning

confidence: 99%

Prevention of cancer and cardiovascular diseases: A common strategy?

et al. 1998

View full text Add to dashboard Cite

Recent implications of weight loss inlung cancer management

et al. 1996

View full text Add to dashboard Cite

Polyunsaturated Fatty Acids and Disease-associated and Cytokine-induced Neurological Manifestations

Turrin

Plata‐Salamán

1998

Nutritional Neuroscience

View full text Add to dashboard Cite

Fish oil supplementation is suggested as possible mean to improve neurological manifestations of chronic diseases and cytokine immunotherapies. Preclinical and clinical studies show that fish oil supplementation seems able to reduce disease-associated anorexia and body weight loss. This improvement could be due to shifts in metabolism and changes in proinflammatory cytokine production and action. ω-3 Polyunsaturated fatty acids (PUFAs), especially eicosapentaenoic acid, are used as substrates for eicosanoid synthesis, competing for enzymes with arachidonic acid, which is a substrate for the synthesis of proinflammatory immunomodulators, such as prostaglandin E2. Fish oil supplementation is generally found to lower production of cytokines including interleukin-1 and tumor necrosis factor-α, thereby reducing various immune responses, including inflammation. However, conflicting results regarding the effects of fish oil interventions have been reported. The main factor that emerges from the contradictory reports is the variety of models, assays and methodologies that have been used. This brief review presents an overall perspective on the potential use of ω-3 PUFAs as a nutritional intervention to ameliorate disease-associated and cytokine-induced neurological manifestations. We conclude that substantial further research is required to understand the exact nature of n-3 PUFA-induced immunomodulation in health and disease.

show abstract

Effects of Eicosapentaenoic Acid on Tumour Growth and Cachexia in Mouse Colon Cancer1

Cited by 3 publications

References 0 publications

Prevention of cancer and cardiovascular diseases: A common strategy?

Prevention of cancer and cardiovascular diseases: A common strategy?

Recent implications of weight loss inlung cancer management

Polyunsaturated Fatty Acids and Disease-associated and Cytokine-induced Neurological Manifestations

Contact Info

Product

Resources

About