Recent implications of weight loss inlung cancer management

Chlebowski, Rowan T.; Palomares, Melanie R.; Lillington, Linda; Grosvenor, Mary B.

doi:10.1016/0899-9007(95)00075-5

Cited by 22 publications

(3 citation statements)

References 49 publications

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“…In the current study, the most frequent gastrointestinal symptoms were anorexia (80/104, 76.92%), nausea (53/104, 50.96%), constipation (49/104, 47.12%), vomiting (48/104, 46.15%), taste disorders (40/104, 38.46%), early satiety (32/104, 30.77%), diarrhea (13/104, 12.50%), and dysphagia (2/104, 1.92%). A similar prevalence of gastrointestinal symptoms was found in other studies [18][19][20] .…”

Section: Discussionsupporting

confidence: 90%

“…The prevalence of unintentional weight loss in patients with NSCLC has been reported to be 38% [16] . Moreover, most patients with advanced NSCLC also present with malnourishment [17][18][19] . The present study observed similar results, and 65.38% (68/104) of the patients experienced unintentional weight loss, whereas 30.77% and 12.5% of the patients manifested ≥ 5% and ≥ 10% degrees of weight loss, respectively, within 6 months before first-line chemotherapy was administered.…”

Section: Discussionmentioning

confidence: 99%

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Nutritional status changes in patients with advanced non-small cell lung cancer receiving first-line chemotherapy

Sun

Liu

Peng

et al. 2018

Oncology and Translational Medicine

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ObjectiveThis study aimed to assess the real-life nutritional status changes and gastrointestinal symptoms in patients with advanced non-small cell lung cancer (NSCLC) receiving chemotherapy.MethodsA total of 104 patients with metastatic NSCLC receiving first-line chemotherapy were included in this study. Unintentional weight loss, body mass index (BMI) changes, and gastrointestinal symptoms were recorded and evaluated. Biochemical parameters [hemoglobin (Hb) and albumin levels] were compared before and after two chemotherapy cycles using SPSS software.ResultsOf these patients, 65.38% (68/104) experienced unintentional weight loss, whereas 30.77%and 12.5% presented with ≥ 5% and ≥ 10% degrees of weight loss, respectively, within 6 months before first-line chemotherapy was administered. Then, 48.08% (50/104) of the patients experienced unintentional weight loss after two chemotherapy cycles. The mean body weight after chemotherapy was 61.47 ± 10.37 kg, which was significantly decreased relative to that before chemotherapy (P< 0.05). The mean BMI after chemotherapy was 22.66 ± 3.34 kg/m2, which was also significantly diminished with respect to that during the previous chemotherapy cycle (P < 0.05). The most common gastrointestinal symptoms reported among all the study patients were anorexia (80/104, 76.92%), nausea (53/104, 50.96%), constipation (49/104, 47.12%), vomiting (48/104, 46.15%), taste disorders (40/104, 38.46%), and early satiety (32/104, 30.77%). The mean Hb levels after chemotherapy were 117.06 ± 16.67 g/L, which were significantly lower than those before chemotherapy (132.73 ± 16.42 g/L) (P < 0.05). No significant difference was noted between the mean albumin levels before and after chemotherapy (38.29 ± 4.22 g/L vs 38.17 ± 4.54 g/L; P = 0.798).ConclusionWeight loss history, gastrointestinal symptoms, and Hb level decreases are determinant factors of nutritional status in patients with advanced NSCLC and must be included in the screening, evaluation, and treatment of lung carcinoma.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Nutritional status changes in patients with advanced non-small cell lung cancer receiving first-line chemotherapy

Sun

Liu

Peng

et al. 2018

Oncology and Translational Medicine

View full text Add to dashboard Cite

show abstract

“…Cachexia is detrimental since it results in an accelerated loss of skeletal muscle in relation to adipose tissue due of altered metabolism. However, in simple starvation fat instead of glucose is the preferred fuel to spare lean body mass (Chlebowski et al, 1996, Tisdale, 1997.…”

Section: Anorexia and Cachexiamentioning

confidence: 99%