Effects of early statin treatment on inflammatory biomarkers and clinical deterioration in patients with acute ischemic stroke

Sakurai, Kenzo; Isahaya, Kenji; Takaishi, Satoshi; Kato, Bunta; Shimizu, K; Shimomura, Kana; Tokuyama, Yoshiaki; Hasegawa, Yasuhiro

doi:10.5692/clinicalneurol.51.6

Cited by 3 publications

(5 citation statements)

References 25 publications

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“…The diagnosis was verified by computer or magnetic resonance tomography of brain in acute stage of the disease (24-48 hours from the first symptoms onset). The consciousness level of the patients varied from clear to moderate stupor (13)(14)(15) points by the Glasgow coma scale). The patients were being enrolled during 2008-2010.…”

Section: Methodsmentioning

confidence: 99%

“…Функционирование неповрежденного эндотелия во многом определяет поддержание адекватного гомеостаза путем регуляции равновесного состояния противоположных процессов -тонуса сосудов (вазодилатация/вазокон-стрикция); их структуры (синтез/ингибирование факторов пролиферации); коагуляции (синтез и ингибирование факторов фибринолиза и агрегации тромбоцитов); мест-ного воспаления (выработка про-и противовоспалитель-ных факторов) [12][13][14][15][16][17]. При этом каждая из четырех вы-шеперечисленных функций эндотелия, определяющих тромбогенность сосудистой стенки, напрямую или кос-венно связана с развитием и прогрессированием атеро-склероза [18][19][20].…”

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“…Adequate homeostasis is maintained due to the function of undamaged endothelium which keeps balance in the following contrary processes: vessel tonus (vasodilatation/vasoconstriction); vessel structure (synthesis/inhibition of proliferative factors); coagulation (synthesis and inhibition of fibrinolysis and platelets aggregation factors); local inflammation (production of pro-and anti-inflammatory factors) [12][13][14][15][16][17]. At that each of these four endothelium functions, determining thrombogenicity of vascular wall, is directly or indirectly associated with atherosclerosis onset and progression [18][19][20].…”

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confidence: 99%

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The Efficacy of High-Dose Simvastatin in Acute Period of Ischemic Stroke

Yakusevich

Malygin

Lychenko

et al. 2012

Racionalʹnaâ farmakoterapiâ v kardiologii

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Aim. To estimate in a 12-month study mortality and frequency of recurrent cardiovascular events, dynamics of neurological deficit and endothelial dysfunction in patients with the first-time ischemic stroke treated with simvastatin 40 mg/day in acute period of the disease. Materials and methods. The efficacy of high-dose simvastatin (40 mg/day) therapy initiated in acute stage of ischemic stroke was evaluated in 12-month comparative randomized study. Patients of the first group (n=97) received standard stroke therapy, and patients of the second group (n=86) also received standard treatment and simvastatin additionally. Combined endpoint (cardiovascular death + recurrent cardiovascular events + necessity of readmission), dynamics of neurological status and endothelial function were considered. Results. Primary combined endpoint was achieved in 66 cases in the first group (68.04%) and in 47 (54.65%) in the second one (p=0.043). Neurological status evaluated by National Institutes of Health Stroke Scale (NIHSS), Mini-Mental State Examination (MMSE) scale, and Scandinavian scales had a faster positive dynamics in patients receiving simvastatin. The same patients revealed more intense and quick decrease in desquamated plasma endotheliocytes. Conclusion. Simvastatin 40 mg/day prescribed along with neuroprotective and antihypertensive treatment in acute stage of ischemic stroke leads to lowering of recurrent cardiovascular events number, positive dynamics of neurological status, regression of endothelial dysfunction reflected by significant decrease in number of circulating desquamated endotheliocytes.

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Section: Methodsmentioning

confidence: 99%

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mentioning

confidence: 99%

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The Efficacy of High-Dose Simvastatin in Acute Period of Ischemic Stroke

Yakusevich

Malygin

Lychenko

et al. 2012

Racionalʹnaâ farmakoterapiâ v kardiologii

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“…Administration of atorvastatin has been reported to contribute to anatomical and functional recovery and to promote the neurogenesis and regeneration of noradrenergic neurons after cerebral ischemia [77]. Clinical trials have demonstrated the effectiveness of statins in reducing the risk of recurrent strokes and improving overall outcomes in individuals with a history of stroke, but there is no consensus on their routine use in the acute phase [78]. Edaravone is a drug used as a neuroprotective agent in the treatment of ischemic stroke.…”

Section: Pharmacotherapymentioning

confidence: 99%

Targeting Neurogenesis in Seeking Novel Treatments for Ischemic Stroke

Nagase,

Kin,

Yasuhara

2023

Biomedicines

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The interruption of cerebral blood flow leads to ischemic cell death and results in ischemic stroke. Although ischemic stroke is one of the most important causes of long-term disability and mortality, limited treatments are available for functional recovery. Therefore, extensive research has been conducted to identify novel treatments. Neurogenesis is regarded as a fundamental mechanism of neural plasticity. Therefore, therapeutic strategies targeting neurogenesis are thought to be promising. Basic research has found that therapeutic intervention including cell therapy, rehabilitation, and pharmacotherapy increased neurogenesis and was accompanied by functional recovery after ischemic stroke. In this review, we consolidated the current knowledge of the relationship between neurogenesis and treatment for ischemic stroke. It revealed that many treatments for ischemic stroke, including clinical and preclinical ones, have enhanced brain repair and functional recovery post-stroke along with neurogenesis. However, the intricate mechanisms of neurogenesis and its impact on stroke recovery remain areas of extensive research, with numerous factors and pathways involved. Understanding neurogenesis will lead to more effective stroke treatments, benefiting not only stroke patients but also those with other neurological disorders. Further research is essential to bridge the gap between preclinical discoveries and clinical implementation.

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“…It has since been demonstrated that statins have some pleiotropic effects, including antithrombotic, inhibiting inflammatory responses, antioxidant activities, stabilizing atherosclerotic plaque, improving endothelial function, increasing endothelial Nitric Oxide (NO) levels, immunomodulatory actions, and reducing cell apoptosis. [5][6][7][8][9][10][11][12][13] Several studies, both experimental and clinical trials, have been conducted to investigate the effects of simvastatin and several other classes of statins on stroke. Statins were found to modulate endothelial Nitric Oxide Synthase (eNOS), reduce Nitric Oxide, and improve cerebral blood flow in the penumbra area in experiments.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Simvastatin on Acute Phase Functional Outcome of Ischemic Stroke

Fidiana

Sugianto

2022

AKSONA : Aksona: Journal of Neurology and Neuroscience

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Introduction: Stroke is one of the leading causes of death and disability worldwide, and especially in Indonesia. Several studies showed the pleiotropic and neuroprotective effect of simvastatin in addition to lowering blood cholesterol levels. Objective: This trial was conducted to investigate if the administration of simvastatin in acute ischemic stroke management can improve functional outcomes. Methods: This randomized, double-blind, placebo-controlled trial of simvastatin was conducted in patients with acute ischemic stroke with an NIHSS score of 4-14. Participants were randomly assigned to receive 40 mg of simvastatin or placebo for seven days. The NIHSS scale was compared on admission day, 4th and 8th day after administration of simvastatin between the two groups. Results: 52 individuals were randomized: 28 to simvastatin and 24 to placebo. There was no significant improvement of functional outcome between the two groups (p > 0.05). Conclusion: Administration of simvastatin had no significant effect on outcome (measured by NIHSS) in patients with acute ischemic stroke.

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Effects of early statin treatment on inflammatory biomarkers and clinical deterioration in patients with acute ischemic stroke

Cited by 3 publications

References 25 publications

The Efficacy of High-Dose Simvastatin in Acute Period of Ischemic Stroke

The Efficacy of High-Dose Simvastatin in Acute Period of Ischemic Stroke

Targeting Neurogenesis in Seeking Novel Treatments for Ischemic Stroke

The Effect of Simvastatin on Acute Phase Functional Outcome of Ischemic Stroke

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