Effects of early nutrition and sanitary conditions on antibody levels in early and later life of broiler chickens

Hollemans, M.S.; Reilingh, G. de Vries; Vries, S. de; Parmentier, H.K.; Lammers, A.

doi:10.1016/j.dci.2020.103954

Cited by 6 publications

(8 citation statements)

References 43 publications

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“…Western blot was conducted for determining the liver protein expression level related to NF-κB signaling pathway. Four replicates per treatment were randomly selected, which was referred to previous studies ( Hollemans et al., 2021 ; Xing et al., 2021 ). Cytoplasmic protein and nuclear protein were obtained using the Nuclear and Cytoplasmic Protein Extraction kit (Beyotime Biotechnology, Shanghai, China) according to the manufacturer's instructions.…”

Section: Methodsmentioning

confidence: 99%

Trans-anethole ameliorates lipopolysaccharide-induced acute liver inflammation in broilers via inhibiting NF-κB signaling pathway

Tong

Xie

et al. 2022

Poultry Science

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Section: Methodsmentioning

confidence: 99%

Trans-anethole ameliorates lipopolysaccharide-induced acute liver inflammation in broilers via inhibiting NF-κB signaling pathway

Tong

Xie

et al. 2022

Poultry Science

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“…More read-out parameters which have already described to be associated in visualizing trained innate immunity and transgenerational epigenetics in mammals, including histone modification analyses or transcriptomics, may be worth considering ( 41 , 47 ). The inconsistency between the outcomes of both experiments could be explained by the biological variation and/or life history of the hens whereby environmental confounding factors such as temperature, hygienic circumstances and the effects of intestinal microbiota should not be ignored ( 48 , 49 ). This indicates the importance of unraveling the mechanisms that are influencing transgenerational inheritance.…”

Section: Discussionmentioning

confidence: 99%

Transgenerational Effects of Maternal Immune Activation on Specific Antibody Responses in Layer Chickens

et al. 2022

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Activation of the maternal immune system may affect innate and adaptive immune responses in the next generation and may therefore have implications for vaccine efficacy and dietary immune modulation by feed additives. However, transgenerational effects on immune responses in chickens have been investigated to a limited extend. The present study investigated effects of intratracheal (i.t) specific and aspecific immune activation of laying hens on specific antibody production in the next generation. In two experiments laying hens received intratracheally an immune stimulus with human serum albumin (HuSA) or lipopolysaccharide (LPS). In experiment 1, hatchlings of the immune activated hens were at 4 weeks i.t. immunized with HuSA or HuSA+LPS. Maternal immune activation with LPS increased HuSA specific IgY and IgM responses in offspring. These results suggest a transgenerational effect of the maternal immune system on the specific antibody response in the next generation. In experiment 2 hatchlings received either β-glucan-enriched feed or control feed and were i.t. immunized with HuSA. Maternal immune activation with LPS decreased IgY anti-HuSA responses after HuSA immunization within hatchlings that received β-glucan enriched feed. The results of Experiment 2 suggest a transgenerational link between the innate immune system of mother and specific antibody responses in offspring. Despite variabilities in the outcomes of the two experiments, the observations of both suggest a link between the maternal innate immune system and the immune system of the offspring. Furthermore, our results may imply that maternal activation of the innate immune system can influence immune modulating dietary interventions and vaccine strategies in the next generation.

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“…The latter could be essential for future implementation of long-term effects of trained innate immunity as a feed or vaccine approach within the poultry husbandry sector. It is important to investigate variability and plasticity of the immune system at early and later life physiology as immune modulating effects also have consequences on metabolism (performance) [92] and behavior (endocrine function) and vice versa [97,98]. What the optimal circumstances are awaits further research wherein this thesis provided valuable information and insights on this.…”

Section: Feed Additive and Vaccine Applicationmentioning

confidence: 96%

“…Tissues suffering from an injury are becoming hypoxic tissues (low oxygen level) and are potentially a site of pathogenic infiltration [91]. Probably under the tight control of HIF-1α, macrophages are apt to infiltrate hypoxic tissues whereby they switch their metabolic program to glycolysis [92]. Furthermore, it has been found that not only the glycolysis but also glutaminolysis and lipogenesis are involved in trained innate immunity [93].…”

Section: ) Metabolic Reprogrammingmentioning

confidence: 99%

“…Differences in animal age, β-glucan/LPS dosage, exposure time, β-glucan/LPS purity and β-glucan/LPS origin might all cause changes that affect gene transcription. Also environmental factors such as temperature, hygienic circumstances and the effects of intestinal microbiota do affect the physiology of an individual and are probably also important explanatory factors for variation in transgenerational effects and immune responses [92,93]. One may speculate that differences in epigenetic profiles between the two experiments in chapter 2 may explain the differential effects on HuSA-specific IgY responses of the offspring.…”

Section: Transgenerational Effects Of the Innate Immune Systemmentioning

confidence: 99%

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Trained innate immunity and transgenerational effects in chickens : A conceptual approach of non-genetic inheritability

Verwoolde

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CHAPTER 1 General introduction CHAPTER 2 Transgenerational effects of maternal immune activation on specific antibody responses in layer chickens CHAPTER 3 Training of Primary Chicken Monocytes Results in Enhanced Pro-Inflammatory Responses CHAPTER 4 Innate immune training and metabolic reprogramming in primary monocytes of broiler and laying hens CHAPTER 5 Transgenerational effects of innate immune activation in broiler breeders on growth performance and immune responsiveness CHAPTER 6 General Discussion

show abstract

Effects of early nutrition and sanitary conditions on antibody levels in early and later life of broiler chickens

Cited by 6 publications

References 43 publications

Trans-anethole ameliorates lipopolysaccharide-induced acute liver inflammation in broilers via inhibiting NF-κB signaling pathway

Trans-anethole ameliorates lipopolysaccharide-induced acute liver inflammation in broilers via inhibiting NF-κB signaling pathway

Transgenerational Effects of Maternal Immune Activation on Specific Antibody Responses in Layer Chickens

Trained innate immunity and transgenerational effects in chickens : A conceptual approach of non-genetic inheritability

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