Trans-anethole ameliorates lipopolysaccharide-induced acute liver inflammation in broilers via inhibiting NF-κB signaling pathway

Seaweed-Derived Polysaccharides Attenuate Heat Stress-Induced Splenic Oxidative Stress and Inflammatory Response via Regulating Nrf2 and NF-κB Signaling Pathways

“…Likewise, Cheng et al [76] and Tong et al [77] demonstrated that the hepatic nuclear NF-κB p65 shows a strong expression signal in the control chicken group, which has a similar relative expression level with the current study. On the other hand, our study also observed significant WB bands of cytoplasmic IκBα in the TN group; this is similar to the results of earlier reports [10,77]. It appears to contradict the findings of nuclear translocation of p65 in the TN group.…”

The targeted anti-Salmonella bacteriophage attenuated the inflammatory response of laying hens challenged with Salmonella Gallinarum

“…The pathogenic pathogen-associated molecular in the intestine influence TLRs to initiate activation of nuclear factor-κB in macrophages and subsequent inflammatory responses ( Kamimura et al, 2017 ; Sutton et al, 2022 ; Tong et al, 2022 ). The TLR stimulation increase production of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 ( Al-Zghoul and Mohammad Saleh, 2020 ).…”

“…The activation of pathogen-associated molecules increases the production of pro-inflammatory cytokines ( Xie et al, 2002 ). Liver is one of the main organs for the synthesis of acute-phase proteins under influence of pro-inflammatory cytokines ( Da Silva et al, 2016 ; Tong et al, 2022 ). In the current study, the increase in liver and spleen weight can be associated with acute-phase proteins and upregulation of inflammatory cytokines including IL-6, TNF-α, and IFNγ.…”

Dietary Garlic Powder Alleviates Lipopolysaccharide-Induced Inflammatory Response and Oxidative Stress through Regulating the Immunity and Intestinal Barrier Function in Broilers

“…TLR4 is a vital sensor for LPS, and can trigger the intracellular association of MyD88 and then activate NF-κB pathway, which subsequently lures the generation and release of inflammatory cytokines [ 31 ]. The signal pathway of TLR4/NF-κB is a complex process involved in the inflammatory response and characterized by a cascade of the expression of both pro-inflammatory (TNF-α, IL-6, and IL-1β) and anti-inflammatory (IL-4 and IL-10) cytokines [ 32 ]. In the model of LPS, we found IL-4 and IL-10 in serum were detected to be decreased, whereas contents of detected pro-inflammatory cytokines were raised, which are consistent with a previous study by Tong et al [ 32 ].…”

“…The signal pathway of TLR4/NF-κB is a complex process involved in the inflammatory response and characterized by a cascade of the expression of both pro-inflammatory (TNF-α, IL-6, and IL-1β) and anti-inflammatory (IL-4 and IL-10) cytokines [ 32 ]. In the model of LPS, we found IL-4 and IL-10 in serum were detected to be decreased, whereas contents of detected pro-inflammatory cytokines were raised, which are consistent with a previous study by Tong et al [ 32 ]. Excessive inflammatory response has already been associated with growth impairment and immune disorder [ 33 ], and similar variations were presented in our study.…”