Effects of Early Intervention With Maternal Fecal Bacteria and Antibiotics on Liver Metabolome and Transcription in Neonatal Pigs

Wan, Jiajia; Lin, Chun-Hui; Ren, Erdu; Su, Yong; Zhu, Weiyun

doi:10.3389/fphys.2019.00171

Cited by 17 publications

(10 citation statements)

References 36 publications

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“…The symbiosis of these core microbiome plays an important role in regulating nutrient metabolism and immunity of the host, ultimately contributing to the health and production performance of pigs ( Geng et al., 2018 ; Kang et al., 2017 ). To date, a myriad of studies have reported that gut microbiota has a high correlation with the immunity, intestinal development, and production performance of swine ( Arnal et al., 2014 ; McCormack et al., 2017 ; Saavedra and Dattilo, 2012 ; Wan et al., 2019 ; Yang et al., 2018a , 2018b ). Specifically, Mach et al.…”

Section: Swine Gut Microbiota and Their Influencing Factorsmentioning

confidence: 99%

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Swine gut microbiota and its interaction with host nutrient metabolism

Wang

Zhang

et al. 2020

Animal Nutrition

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Gut microbiota is generally recognized to play a crucial role in maintaining host health and metabolism. The correlation among gut microbiota, glycolipid metabolism, and metabolic diseases has been well reviewed in humans. However, the interplay between gut microbiota and host metabolism in swine remains incompletely understood. Given the limitation in conducting human experiments and the high similarity between swine and humans in terms of anatomy, physiology, polyphagy, habits, and metabolism and in terms of the composition of gut microbiota, there is a pressing need to summarize the knowledge gained regarding swine gut microbiota, its interplay with host metabolism, and the underlying mechanisms. This review aimed to outline the bidirectional regulation between gut microbiota and nutrient metabolism in swine and to emphasize the action mechanisms underlying the complex microbiome–host crosstalk via the gut microbiota–gut–brain axis. Moreover, it highlights the new advances in knowledge of the diurnal rhythmicity of gut microbiota. A better understanding of these aspects can not only shed light on healthy and efficient pork production but also promote our knowledge on the associations between gut microbiota and the microbiome–host crosstalk mechanism. More importantly, knowledge on microbiota, host health and metabolism facilitates the development of a precise intervention therapy targeting the gut microbiota.

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Section: Swine Gut Microbiota and Their Influencing Factorsmentioning

confidence: 99%

“…In addition, other intervention approaches (e.g. faecal microbial transplantation and early feeding) affect the composition and function of gut microbiota ( Cheng et al., 2018 ; Lin et al., 2018 ; Shi et al., 2018 ; Wan et al., 2019 ; Xu et al., 2020 ).…”

Section: Swine Gut Microbiota and Their Influencing Factorsmentioning

confidence: 99%

Swine gut microbiota and its interaction with host nutrient metabolism

Wang

Zhang

et al. 2020

Animal Nutrition

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“…Altered patterns of community assembly in young hosts has been associated with dysbiosis ( Neuman et al, 2018 ) and increased susceptibility to disease ( Arruda et al, 2013 ). Conversely, microbiome management strategies are often most successful when applied in the earlier stages of community assembly in host microbiomes ( Lin et al, 2018 ; Wan et al, 2019 ; Wang et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Age Matters: Community Assembly in the Pig Fecal Microbiome in the First Month of Life

Jurburg

Bossers

2021

Front. Microbiol.

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Despite the wealth of research into strategies for microbiome modulation, studies of microbiome management in pig hosts have found mixed results. A refined understanding of the patterns of microbiome assembly during the host’s early life, when management strategies are most commonly applied, is necessary for the development of successful management practices. Here, we study the development of the pig gut microbial community in a monitoring experiment, sampling the microbiome of pigs in a commercial farm intensively during the first month of life. We found that the community’s taxonomic richness increased linearly with host age. Furthermore, rapid changes across communities occurred in stages, and non-linear patterns in relative abundance were commonly observed among dominant taxa across host age, consistent with primary succession. Our results highlight the importance of understanding the patterns of microbiome assembly during host development, and identify successional stages as windows of opportunity for future research.

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“…The down-regulation of 1-Pyrroline-5-carboxylate dehydrogenase might be related to the inhibition of the TCA cycle and the oxidative decarboxylation of isocitrate, which would reduce the production of energy and the supplementation of NADP. Additionally, arginosuccinate synthetase catalyzes the transformation of aspartate into arginine, which serves as the penultimate step of arginine biosynthesis [41], all of this information suggests that protein synthesis was inhibited during treatment with actinomycin D.…”

Section: Discussionmentioning

confidence: 99%

Multi-Omics Analysis Reveals Anti-Staphylococcus aureus Activity of Actinomycin D Originating from Streptomyces parvulus

Lin

Huang

Zhang

et al. 2021

IJMS

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Staphylococcus aureus (S. aureus) is a common pathogen that causes various serious diseases, including chronic infections. Discovering new antibacterial agents is an important aspect of the pharmaceutical field because of the lack of effective antibacterial drugs. In our research, we found that one anti-S. aureus substance is actinomycin D, originating from Streptomyces parvulus (S. parvulus); then, we further focused on the anti-S. aureus ability and the omics profile of S. aureus in response to actinomycin D. The results revealed that actinomycin D had a significant inhibitory activity on S. aureus with a minimum inhibitory concentration (MIC) of 2 μg/mL and a minimum bactericidal concentration (MBC) of 64 μg/mL. Bacterial reactive oxygen species (ROS) increased 3.5-fold upon treatment with actinomycin D, as was measured with the oxidation-sensitive fluorescent probe DCFH-DA, and H2O2 increased 3.5 times with treatment by actinomycin D. Proteomics and metabolomics, respectively, identified differentially expressed proteins in control and treatment groups, and the co-mapped correlation network of proteomics and metabolomics annotated five major pathways that were potentially related to disrupting the energy metabolism and oxidative stress of S. aureus. All findings contributed to providing new insight into the mechanisms of the anti-S. aureus effects of actinomycin D originating from S. parvulus.

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Effects of Early Intervention With Maternal Fecal Bacteria and Antibiotics on Liver Metabolome and Transcription in Neonatal Pigs

Cited by 17 publications

References 36 publications

Swine gut microbiota and its interaction with host nutrient metabolism

Swine gut microbiota and its interaction with host nutrient metabolism

Age Matters: Community Assembly in the Pig Fecal Microbiome in the First Month of Life

Multi-Omics Analysis Reveals Anti-Staphylococcus aureus Activity of Actinomycin D Originating from Streptomyces parvulus

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