Effects of Early Experience on the Response to Transplanted Tumor

Newton, G. L.; Bly, C. G.; Mccrary, Cedric

doi:10.1097/00005053-196206000-00004

Cited by 22 publications

(13 citation statements)

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“…These results, and especially the enhanced activity of NK cells that are known to be involved in the killing of tumor cells, are in agreement with previous work showing that postnatal stress can enhance tumor resistance in adulthood (Ader & Friedman, 1965;Dechambre & La Barba, 1978;Levine, 1962;Newton et al, 1962). On the other hand, the increase in T-lymphocyte reactivity appears to be in contrast with the depressed T-cell response, assessed by the plaque-forming cell response to sheep blood cells in adult mice following postnatal stress (Michaut et al, 1981;Raymond et al, 1986).…”

Section: Discussionsupporting

confidence: 92%

Influence of early life events on immune reactivity in adult mice

Neveu

Deleplanque

Puglisi-Allegra

et al. 1994

Developmental Psychobiology

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The effects of postnatal manipulations on different immune parameters were investigated in adult female mice. Postnatal stress consisted of a 15-min daily exposure to clean bedding (temperature maintained at 35 degrees C) for the first 2 weeks of life in the absence of the mother but in the presence of littermates. Controls were unhandled until weaning. At 60 days of age, female mice stressed during postnatal development showed enhanced immune reactivity as assessed by NK-cell activity and T-cell mitogenesis in comparison with unhandled mice. By contrast, B-lymphocyte proliferation induced by lipopolysaccharide (LPS) was not affected by alterations of postnatal environment. Furthermore, the association between immune reactivity and behavioral lateralization observed in adult mice was not altered by postnatal stress.

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Section: Discussionsupporting

confidence: 92%

Influence of early life events on immune reactivity in adult mice

Neveu

Deleplanque

Puglisi-Allegra

et al. 1994

Developmental Psychobiology

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“…It should be noted, however, that although we previously found that 10 inescapable shock sessions had effects that went beyond simply blocking the acute stress-induced tumor enhancement and actually inhibited tumor growth relative to nonshocked controls such an effect was not evident in the present experiment. This is not entirely surprising, in view of the fact that the inhibition we previously observed was quite small and the chronic stress regimens typically employed in studies reporting inhibited tumor growth are considerably more extensive (see [30][31][32][33][34][35][36][37][38][39][40][41][42].…”

Section: Methodsmentioning

confidence: 77%

“…The mitigation of the acute stress effects and the inhibitory effects of chronic stress that have been reported (30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42) may be attributable to factors other than the chronicity of the stress regimen. Specifically, it has been demonstrated that the stage of tumor development at which stress is introduced may influence the subsequent effects of stress (15,30,35).…”

Section: Methodsmentioning

confidence: 99%

“…With respect to the infra-human investigations, it has been reported that stress may either exacerbate (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) or inhibit (14,(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42) tumorigenicity. Aside from stress type and social conditions (2,43), two important factors that contribute to these contradictory findings are ability to control stress and chronicity of stress.…”

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confidence: 99%

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Adaptation to the Tumor-Enhancing Effects of Stress

Sklar¹,

Bruto²,

Anisman³

1981

Psychosomatic Medicine

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Growth of P815 mastocytoma in syngeneic DBA/2J male mice was evaluated following several stress regimens. Although escapable shock did not enhance tumor growth, an equivalent amount of inescapable shock applied in a yoked paradigm markedly augmented tumor development. If mice received repeated stress sessions on 5-10 consecutive following tumor cell transplantation, the tumor-enhancing effects of an acute session were abrogated. This effect was not due to an antitumor effect exerted by a shock session applied several days after cell transplantation. It seems that the tumorigenic effects of stress are subject to adaptation since stress exposure prior to cell transplantation also inhibited the effects of an acute stress session. The data were discussed in relation to stress-induced neurochemical alterations.

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“…In general, the latter data as well as reviews to date suggest that emotional stress may exert a facilitating influ ence on cancer growth. The effect of preweaning stimulation, handling and rearing in large groups has been evaluated in rats and mice either predisposed to the lesion or injected at a later period with the tumor [1,2,9,11,14,16,17].…”

Section: Introductionmentioning

confidence: 99%

Influence of Stress on Lesion Growth and on Survival of Animals Bearing Parenteral and Intracerebral Leukemia L1210 and Walker Tumors

Gershbein¹,

Benuck²,

Shurrager³

1974

Oncology

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Rats with Walker tumor injected intramuscularly in both hind legs and subjected to forced swimming for 15 min daily for 10 days displayed a trend toward decreased lesion size, especially in older intact animals as compared to unexercised intact or bilaterally adrenalectomized controls. Secondary tumor nodules occurred at the lower abdominal or inguinal areas and appeared to be more extensive in the older exercised rats. The survival rates offorced exercised rats bearing Walker tumor cortically did not differ significantly from the respective controls as was also the case with adult BDF₁ mice with intraperitoneal or cortical L1210 tumor and subjected daily to electroshock at 0.25 mA for 15 min.

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Effects of Early Experience on the Response to Transplanted Tumor

Cited by 22 publications

References 0 publications

Influence of early life events on immune reactivity in adult mice

Influence of early life events on immune reactivity in adult mice

Adaptation to the Tumor-Enhancing Effects of Stress

Influence of Stress on Lesion Growth and on Survival of Animals Bearing Parenteral and Intracerebral Leukemia L1210 and Walker Tumors

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