Effects of dysthyroidism in plus maze and social interaction tests

Roca, Josefina Sala; Martí-Carbonell, Maria Assumpció; Garau, A; Darbra, Sònia; Balada, Ferran

doi:10.1016/s0091-3057(02)00718-9

Cited by 24 publications

(16 citation statements)

References 45 publications

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“…In the present study we investigated the effect of a chemically induced model of adult onset hypothyroidism on behavioral parameters (fear/ anxiety and learning/memory) and on the activity of two isoforms of the AChE in five specific brain regions of male mice. In our experimental set-up, adult onset hypothyroidism was effectively performed as indicated by the decreased body weight gain of hypothyroid mice at the end of KClO 4 treatment, in accordance to our previous findings [45] and the literature [17,47,48]. In addition, our biochemical studies were performed in the same animals used for the OF and EPM tasks as mentioned in Materials and methods.…”

Section: Discussionsupporting

confidence: 81%

“…In addition, the effects of hypothyroidism on anxiety-like behavior and locomotor activity are rather independent of the species and the gender used. Moreover, it has been shown that MMI-induced perinatal hypothyroidism increases the locomotor activity of the animals as measure with the EPM test, indicating thus that age maybe a factor of regulating differential response to hypothyroidism [17]. Furthermore, mice deficient in thyrotropin-releasing hormone receptor isoform 1 (TRH-receptor-1) an alternative, well established hypothyroid mutant, also exhibited anxiety-like behavior when performing EPM test.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, thyroid hormone deficiency increases the probability of depressive illness [16], whereas thyroid excess increases the probability of mania in susceptible individuals [15]. In addition, increased fear/anxiety and depression-like behavior, decreased locomotor activity and loss of memory have been established also in hypothyroid rodents [12,17].…”

Section: Introductionmentioning

confidence: 99%

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Effect of adult onset hypothyroidism on behavioral parameters and acetylcholinesterase isoforms activity in specific brain regions of male mice

Vasilopoulou

Constantinou

Giannakopoulou

et al. 2016

Physiology & Behavior

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of adult onset hypothyroidism on behavioral parameters and acetylcholinesterase isoforms activity in specific brain regions of male mice

Vasilopoulou

Constantinou

Giannakopoulou

et al. 2016

Physiology & Behavior

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“…In animals, hyperthyroidism in adulthood leads to increased activity in the open field test [46,50], and both experimental hypo- [25] and hyperthyroidism [46] have been reported to increase immobility behavior in the forced swim test. Spatial learning and memory deficits have been found in the genetically hypothyroid hyt/hyt mouse [3], and in congenitally hypothyroid animals [1,2,32].…”

Section: Introductionmentioning

confidence: 99%

Behavioral inhibition and impaired spatial learning and memory in hypothyroid mice lacking thyroid hormone receptor α

Wilcoxon

Nadolski

Samarut

et al. 2007

Behavioural Brain Research

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Thyroid hormone insufficiency leads to impaired neurogenesis, behavioral alterations and cognitive deficits. Thyroid hormone receptors, expressed in brain regions involved in these behaviors, mediate the effects of thyroid hormone deficiency or excess. To determine the contribution of thyroid hormone receptor alpha (TRα) in these behaviors, we examined the behavior of euthyroid as well as hypo-and hyperthyroid mice lacking all isoforms of the TRα (TRα o/o ). The hypothyroxinemic TRα o/o mice demonstrated behavioral inhibition, manifested in decreased activity and increased anxiety/fear in the open field test (OFT) and increased immobility in the forced swim test (FST) compared to C57BL/6J mice. TRα o/o mice also showed learning and recall impairments in the Morris water maze (MWM), which were exaggerated by hypothyroidism in TRα o/o mice. These impairments were concurrent with increased thigmotaxis, suggesting an increased anxiety-like state of the TRα o/o mice in the MWM. Expression of genes, known to be involved in processes modulating learning and memory, such as glucocorticoid receptor (GR), growth-associated protein 43 (GAP-43) and neurogranin (RC3), were significantly decreased in the hippocampus of TRα o/o mice. GR expression was also decreased in the frontal cortex and amygdala of TRα o/o mice, indicating that expression of GR is regulated, probably developmentally, by one or more isoforms of TRα in the mouse brain. Taken together these data demonstrate behavioral alterations in the TRα o/o mice, indicating the functional role of TRα, and a delicate interaction between TRα and TRβ-regulated genes in these behaviors. Thyroid hormone-regulated genes potentially responsible for the learning deficit found in TRα o/o mice include GR, RC3 and GAP-43.

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“…The somatic symptoms include weight loss, tachycardia, excessive sweating, increased appetite, tremor and changes in bowel patterns (4). Two third of patients with thyroid disease have been reported to have psychological symptoms (5,6). Hyperthyroidism has been associated with anxiety, depression, irritability, insomnia and low concentration in several studies (7,8).…”

Section: Introductionmentioning

confidence: 99%

Dose the Clinical Characteristics of Patients with Anxiety due to Hyperthyroidism Differ from Patients with Generalized Anxiety Disorder? A Comparative Study

Mowla

Kalantarhormozi

Khazraee

2016

Iran J Psychiatry Behav Sci

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Background: Hyperthyroidism is associated with anxiety symptoms. Objectives: The aim of this study was to compare the clinical characteristics of patients with anxiety due to hyperthyroidism with patients with generalized anxiety disorder (GAD). Materials and Methods:This study was carried out in Abolfazl psychiatry clinic affiliated to Bushehr University of Medical Sciences from September 2012 to September 2013. Anxiety severity and characteristics of thirty-two patients with GAD was compared to 34 patients with anxiety due to hyperthyroidism. Hamilton anxiety rating scale (HAM-A) was used to evaluate the overall anxiety severity and anxiety symptom profile of the two groups. Results: There was no significant difference regarding overall anxiety severity between the two groups (P = 0.65). Autonomic symptoms were more sever in hyperthyroid patients (P = 0.003) whereas anxious mood and fears were more prominent in patients with GAD (P = 0.001 and P = 0.045, respectively). Conclusions: This study demonstrated that patients with GAD reported more psychology symptoms of anxiety whereas physical symptoms of anxiety were more prominent in hyperthyroid patients. Our findings may help differentiate these two disorders in the clinic, based on the symptom profile. However, it is important to note that this study is preliminary, and larger studies are needed to confirm the results.

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Effects of dysthyroidism in plus maze and social interaction tests

Cited by 24 publications

References 45 publications

Effect of adult onset hypothyroidism on behavioral parameters and acetylcholinesterase isoforms activity in specific brain regions of male mice

Effect of adult onset hypothyroidism on behavioral parameters and acetylcholinesterase isoforms activity in specific brain regions of male mice

Behavioral inhibition and impaired spatial learning and memory in hypothyroid mice lacking thyroid hormone receptor α

Dose the Clinical Characteristics of Patients with Anxiety due to Hyperthyroidism Differ from Patients with Generalized Anxiety Disorder? A Comparative Study

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