Effect of adult onset hypothyroidism on behavioral parameters and acetylcholinesterase isoforms activity in specific brain regions of male mice

Vasilopoulou, Catherine G.; Constantinou, Caterina; Giannakopoulou, Dimitra; Giompres, Panagiotis; Margarity, Marigoula

doi:10.1016/j.physbeh.2016.06.016

Cited by 12 publications

(4 citation statements)

References 70 publications

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“…Several behavioral studies reported that adult-onset hypothyroidism in rodents induces learning and memory impairment. In particular the identified alterations did not involve only short-term and long-term forms of memory but also the acquisition phase of the different behavioral tests used [107,108]. This data is further corroborated by the evidence that thyroid hormone deficiency is able to produce electrophysiological and biochemical alterations in the hippocampus, an area that plays a key role in memory processes.…”

Section: Classical Thyroid Hormone Effects On Adult Brainsupporting

confidence: 60%

Effects of Thyroid Hormones and their Metabolites on Learning and Memory in Normal and Pathological Conditions

Accorroni

Chiellini

Origlia

2017

CDM

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Section: Classical Thyroid Hormone Effects On Adult Brainsupporting

confidence: 60%

Effects of Thyroid Hormones and their Metabolites on Learning and Memory in Normal and Pathological Conditions

Accorroni

Chiellini

Origlia

2017

CDM

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“…With respect to euthyroid mice, hypothyroid animals showed a greater anxiety, assessed with the open-field test, along with worse spatial orientation, assessed with the water Morris maze test, and reduced motor activity in the forced swim test [103]. Similarly, hypothyroid adult rodents showed greater emotional vulnerability, displaying more frequent anxious behaviours and a state of fear, as evaluated with the open-field and elevated plus-maze tests [102,104,105].…”

Section: Ths and In Vivo Models Of Cognitive/emotional Impairmentmentioning

confidence: 98%

“…Aside from cognitive abilities, emotional behaviours such as fear and anxiety are also modified by TH deficiencies, as assessed using elevated plus-maze and open-field tests [102]. With respect to euthyroid mice, hypothyroid animals showed a greater anxiety, assessed with the open-field test, along with worse spatial orientation, assessed with the water Morris maze test, and reduced motor activity in the forced swim test [103].…”

Section: Ths and In Vivo Models Of Cognitive/emotional Impairmentmentioning

confidence: 99%

Factors and Mechanisms of Thyroid Hormone Activity in the Brain: Possible Role in Recovery and Protection

Sabatino,

Lapi,

Del Seppia

2024

Biomolecules

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Thyroid hormones (THs) are essential in normal brain development, and cognitive and emotional functions. THs act through a cascade of events including uptake by the target cells by specific cell membrane transporters, activation or inactivation by deiodinase enzymes, and interaction with nuclear thyroid hormone receptors. Several thyroid responsive genes have been described in the developing and in the adult brain and many studies have demonstrated a systemic or local reduction in TH availability in neurologic disease and after brain injury. In this review, the main factors and mechanisms associated with the THs in the normal and damaged brain will be evaluated in different regions and cellular contexts. Furthermore, the most common animal models used to study the role of THs in brain damage and cognitive impairment will be described and the use of THs as a potential recovery strategy from neuropathological conditions will be evaluated. Finally, particular attention will be given to the link observed between TH alterations and increased risk of Alzheimer’s Disease (AD), the most prevalent neurodegenerative and dementing condition worldwide.

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“…- Vasilopoulou et al 2016: this in vivo study investigated the effects of adult onset hypothyroidism (induced by administration of 1% w/v KClO4 in their drinking water for 8 weeks in adult male Balb/cJ mice) on acetylcholinesterase (AChE) activity and on related behavioral parameters. They found that adult onset hypothyroidism (TH levels were not measured in this study) caused decrease of memory and increased fear/anxiety (i.e., 51%…”

Section: │ 175mentioning

confidence: 99%

Adverse Outcome Pathway on inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment

Rolaki

Pistollato

Munn

et al. 2019

OECD Series on Adverse Outcome Pathways

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This Adverse Outcome Pathway (AOP) on Inhibition of Na+/I-symporter (NIS) leads to learning and memory impairment, has been developed under the auspices of the OECD AOP Development Programme, overseen by the Extended Advisory Group on Molecular Screening and Toxicogenomics (EAGMST), which is an advisory group under the Working Group of the National Coordinators for the Test Guidelines Programme (WNT). The AOP has been reviewed internally by the EAGMST, externally by experts nominated by the WNT, and has been endorsed by the WNT and the Working Party on Hazard Assessment (WPHA) in May 2019. Through endorsement of this AOP, the WNT and the WPHA express confidence in the scientific review process that the AOP has undergone and accept the recommendation of the EAGMST that the AOP be disseminated publicly. Endorsement does not necessarily indicate that the AOP is now considered a tool for direct regulatory application. The Joint Meeting of the Chemicals Committee and the Working Party on Chemicals, Pesticides and Biotechnology agreed to declassification of this AOP on 26 June 2019. This document is being published under the responsibility of the Joint Meeting of the Chemicals Committee and the Working Party on Chemicals, Pesticides and Biotechnology. The outcome of the internal and external reviews are publicly available respectively in the AOP Wiki and the eAOP Portal of the AOP Knowledge Base at the following links: [internal review] [external review].

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Effect of adult onset hypothyroidism on behavioral parameters and acetylcholinesterase isoforms activity in specific brain regions of male mice

Cited by 12 publications

References 70 publications

Effects of Thyroid Hormones and their Metabolites on Learning and Memory in Normal and Pathological Conditions

Effects of Thyroid Hormones and their Metabolites on Learning and Memory in Normal and Pathological Conditions

Factors and Mechanisms of Thyroid Hormone Activity in the Brain: Possible Role in Recovery and Protection

Adverse Outcome Pathway on inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment

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