Effects of Drug Vehicles on Ocular Uptake of Tetracycline

Ocular Pharmacokinetics

“…7. In fact, examination of about 300 papers reporting such experiments revealed only three or four sets of data that were HARDBERGER et al 1975;h KLEINBERG et al 1979;i GREEN and MACKEEN 1976;i BEASLEY et al 1975;k SIEG and ROBINSON 1976;I LAZARE and HORLINGTON 1975;m TAKASE (cited MISIllMA 1981); n PIllLLIPS et al ° YAMAUCHI et al 1975;P KUPFERMAN and LEIBOWITZ 1976;Q SHORT et al 1966;'JAIN and BATRA 1979;s ROSENBLUM et al 1967;, KUPFERMAN and LEIBOWITZ 1975;u BLOOME et al 1970;v BLEEKER and MAAS 1955;W SENDELBECK et al 1975;x SCHMITT et al 1980;Y KUPFERMAN and LEIBOWITZ 1974 b k"…”

Doxycycline in the Management of Pseudomonas Corneal Melting

“…Therapeutic topical application therefore is limited. 39 In a study of tetracycline levels in rabbit and human eyes, orally and intravenously administered levels had detectable levels in the aqueous, but topical administration showed little penetration through an intact cornea into the aqueous. 38 Another study showed that although tetracycline can be detected in the aqueous after systemic administration, vitreous levels were negative.…”

Benzalkonium Chloride and Gentamicin Cause a Leak in Corneal Epithelial Cell Membrane

“…Besides, super®cial corneal epithelial cells, whether healthy or not, may be disrupted when in contact with these antibiotic/preservative solutions, and may exert even less protective effect on the basal cells. When antibiotic ointments are used, the celldisrupting effect may be even more signi®cant by its prolonged continuous contact as well as poor dilution and washout of the ointment by the tearing effect (Hardberger, Hanna and Goodart, 1975). Unfortunately, these eyes are usually those most pathologic eyes and need intensive antibiotic treatment, with or without preservatives.…”