Benzalkonium Chloride and Gentamicin Cause a Leak in Corneal Epithelial Cell Membrane

Effects of Benzalkonium Chloride, a Preservative in Topical Drugs, on the Barrier Function of Human Corneal Epithelial Cells

“…This agrees with prior research linking BAK to epithelial barrier dysfunction. 3 – 5 , 39 , 40 Notably, 0.01% and 0.02% BAK raised capacitance threefold within the first hour, remaining high and showing no recovery during the monitoring period.…”

Effects of Benzalkonium Chloride, a Preservative in Topical Drugs, on the Barrier Function of Human Corneal Epithelial Cells

“…This agrees with prior research linking BAK to epithelial barrier dysfunction. 3 – 5 , 39 , 40 Notably, 0.01% and 0.02% BAK raised capacitance threefold within the first hour, remaining high and showing no recovery during the monitoring period.…”

Comparative effects of antiglaucoma drugs on voltage-dependent calcium channels

“…Corneal epithelial cells may express L-type VDDCs [50] and hence an interaction of topical benzalkonium chloride with these channels could affect the physiology of the corneal surface. Interestingly, benzalkonium chloride has been found to increase intracellular Ca 2+ in cultured rabbit corneal epithelial cells [18] and cause a leak in corneal epithelial cell membrane [8]. Cytotoxic effects of benzalkonium chloride have also been recorded, but whether this involves an interaction with L-type VDCCs is unknown.…”

The Effects of Epithelial Viability on Stromal Keratocyte Apoptosis in Porcine Corneas Stored in Optisol-GS

“…27 Optisol-GS contains gentamicin 0.1 mg/mL and streptomycin sulfate 0.2 mg/mL. It is not known whether this concentration would cause a change in the corneal epithelial and/or endothelial cell membrane after prolonged storage in the medium.…”

Effects of Benzalkonium Chloride, a Preservative in Topical Drugs, on the Barrier Function of Human Corneal Epithelial Cells

“…This agrees with prior research linking BAK to epithelial barrier dysfunction. 3 – 5 , 39 , 40 Notably, 0.01% and 0.02% BAK raised capacitance threefold within the first hour, remaining high and showing no recovery during the monitoring period.…”

Comparative effects of antiglaucoma drugs on voltage-dependent calcium channels

“…Corneal epithelial cells may express L-type VDDCs [50] and hence an interaction of topical benzalkonium chloride with these channels could affect the physiology of the corneal surface. Interestingly, benzalkonium chloride has been found to increase intracellular Ca 2+ in cultured rabbit corneal epithelial cells [18] and cause a leak in corneal epithelial cell membrane [8]. Cytotoxic effects of benzalkonium chloride have also been recorded, but whether this involves an interaction with L-type VDCCs is unknown.…”

The Effects of Epithelial Viability on Stromal Keratocyte Apoptosis in Porcine Corneas Stored in Optisol-GS

“…27 Optisol-GS contains gentamicin 0.1 mg/mL and streptomycin sulfate 0.2 mg/mL. It is not known whether this concentration would cause a change in the corneal epithelial and/or endothelial cell membrane after prolonged storage in the medium.…”

Effects of Benzalkonium Chloride, a Preservative in Topical Drugs, on the Barrier Function of Human Corneal Epithelial Cells

“…This agrees with prior research linking BAK to epithelial barrier dysfunction. 3 – 5 , 39 , 40 Notably, 0.01% and 0.02% BAK raised capacitance threefold within the first hour, remaining high and showing no recovery during the monitoring period.…”

Comparative effects of antiglaucoma drugs on voltage-dependent calcium channels

“…Corneal epithelial cells may express L-type VDDCs [50] and hence an interaction of topical benzalkonium chloride with these channels could affect the physiology of the corneal surface. Interestingly, benzalkonium chloride has been found to increase intracellular Ca 2+ in cultured rabbit corneal epithelial cells [18] and cause a leak in corneal epithelial cell membrane [8]. Cytotoxic effects of benzalkonium chloride have also been recorded, but whether this involves an interaction with L-type VDCCs is unknown.…”

The Effects of Epithelial Viability on Stromal Keratocyte Apoptosis in Porcine Corneas Stored in Optisol-GS

“…27 Optisol-GS contains gentamicin 0.1 mg/mL and streptomycin sulfate 0.2 mg/mL. It is not known whether this concentration would cause a change in the corneal epithelial and/or endothelial cell membrane after prolonged storage in the medium.…”