Effects of drug solubility on the release kinetics of water soluble and insoluble drugs from HPMC based matrix formulations

Chakraborty, Santanu; Khandai, Madhusmruti; Sharma, Anuradha; Patra, Chinam Niranjan; Patro, V. J.; Sen, Kalyan Kumar

doi:10.2478/v10007-009-0025-8

Cited by 35 publications

(21 citation statements)

References 14 publications

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“…Table III summarizes the calculated release parameters applying different models as zero‐order, first‐order, and Korsmeyer–Peppas 46. All data fit very well with Korsmeyer–Peppas model by R 2 ≥ 0.995, which confirms the release kinetics of a water‐insoluble drug 47. In the Korsmeyer–Peppas model, when the release exponent n = 0.43, it theoretically indicates a diffusion‐controlled mode, while n = 0.85 indicates a swelling‐controlled mode 46.…”

Section: Resultssupporting

confidence: 58%

Paclitaxel‐loaded silk fibroin nanospheres

Chen

Shao

Chen

2011

J Biomedical Materials Res

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Silk fibroin is a very promising biomedical material because of its renewability, nontoxicity, biocompatibility, and biodegradability. On the basis of a simple and mild method for the preparation of silk fibroin nanospheres with controllable size, the authors developed earlier, anti-cancer drug paclitaxel (PTX)-loaded silk fibroin nanospheres ranging from 270 to 520 nm were produced accordingly. The drug loading, encapsulation efficiency, and released property of PTX-loaded silk fibroin nanospheres are depended on the silk fibroin concentration and initial PTX-loading capacity. The maximum drug loading is about 6.9% and the release time of such a kind of nanospheres is over 9 days. The release time of PTX-loaded silk fibroin nanospheres can be as long as 2 weeks when the drug loading is about 3.0%. All these results imply that such a kind of biomacromolecule-based anti-cancer drug nanocarrier has a great potential for chemotherapy in clinical applications.

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Section: Resultssupporting

confidence: 58%

Paclitaxel‐loaded silk fibroin nanospheres

Chen

Shao

Chen

2011

J Biomedical Materials Res

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“…Chakraborty et al has explained that the release kinetics of a water-insoluble drug such as verapamil from HPMC based formulations follows Korsmeyer-Peppas model. It means that drug release occurred through diffusion in the hydrated matrix and polymer relaxation [65]. So it can be acceptable for water-insoluble paclitaxel too.…”

Section: In Vitro Drug Releasementioning

confidence: 98%

Preparation and characterization of biodegradable paclitaxel loaded alginate microparticles for pulmonary delivery

Alipour

Montaseri

Tafaghodi

2010

Colloids and Surfaces B: Biointerfaces

120

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“…However, many researchers involved in the development of the PPN sustained-release dosage forms met with problems, such as difficulty in the control of drug release due to the high aqueous solubility of PPN. These challenges led to the use of a large amount of polymer in the matrix tablets to support the sustained release of a drug with high water solubility[14]. Recently, it was shown that PPN could electrostatically interact with MAS to form intercalated complexes.…”

mentioning

confidence: 99%

“…Hydroxypropylmethylcellulose (HPMC) has been widely used as a hydrophilic matrix forming agent[14–17] and was employed in this study. Additionally, the effects of HPMC viscosity grades, compression pressures and calcium acetate incorporation on the PPN release characteristics of the PPN–MAS complex tablets were also examined.…”

mentioning

confidence: 99%

Use of propranolol-magnesium aluminium silicate intercalated complexes as drug reservoirs in polymeric matrix tablets

Rojtanatanya¹

2012

Indian J Pharm Sci

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The objective of the present study was to investigate the use of propranolol–magnesium aluminium silicate intercalated complexes as drug reservoirs in hydroxypropylmethylcellulose tablets. The matrix tablets containing the complexes were prepared and characterised with respect to propranolol release and were subsequently compared with those loading propranolol or a propranolol–magnesium aluminium silicate physical mixture. Additionally, the effects of varying viscosity grades of hydroxypropyl methylcellulose, compression pressures and calcium acetate incorporation on the drug release characteristics of the complex-loaded tablets were also examined. The results showed that the complex-loaded tablets have higher tablet hardness than those containing propranolol or a physical mixture. The drug release from the complex-loaded tablets followed a zero-order release kinetic, whereas an anomalous transport was found in the propranolol or physical mixture tablets. The drug release rate of the complex tablet significantly decreased with increasing hydroxypropylmethylcellulose viscosity grade. Increase in the compression pressure caused a decrease in the drug release rate of the tablets. Furthermore, the incorporation of calcium ions could accelerate propranolol release, particularly in acidic medium, because calcium ions could be exchanged with propranolol molecules intercalated in the silicate layers of magnesium aluminium silicate. These findings suggest that propranolol-magnesium aluminium silicate intercalated complexes show strong potential for use as drug reservoirs in matrix tablets intended for modifying drug release.

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Effects of drug solubility on the release kinetics of water soluble and insoluble drugs from HPMC based matrix formulations

Cited by 35 publications

References 14 publications

Paclitaxel‐loaded silk fibroin nanospheres

Paclitaxel‐loaded silk fibroin nanospheres

Preparation and characterization of biodegradable paclitaxel loaded alginate microparticles for pulmonary delivery

Use of propranolol-magnesium aluminium silicate intercalated complexes as drug reservoirs in polymeric matrix tablets

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