Effects of Drug Pretreatment on Antipyrine Elimination in the Rabbit

Chambers, D M; Jefferson, Gordon C

doi:10.1159/000137581

Cited by 12 publications

(6 citation statements)

References 15 publications

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“…Consider ation of both sets of data illustrates the diffi culties in the extrapolation of studies of drug metabolism in animals to man. A similar interspecies difference was reported by Chambers and Jefferson [7] who observed lit tle effect of the potent inhibitor of hepatic oxidative drug metabolism, SKF 525A [10] on antipyrine kinetics in the rabbit. The inac tivity of propoxyphene in the rabbit could reflect differences in its hepatic metabolism or distribution in the rabbit compared to man, or the ability of the rabbit to switch to an alternative pathway for antipyrine elimi nation, which is not available to the same extent in man.…”

Section: Discussionsupporting

confidence: 83%

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Absence of Effect of Propoxyphene on Antipyrine Kinetics in the Rabbit

Paxton¹

1983

Pharmacology

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The effect of propoxyphene on the elimination kinetics of antipyrine was examined in New Zealand white rabbits. Serum concentrations of antipyrine were measured by high-performance liquid chromatography (HPLC). No significant alterations in the elimination half-life, apparent volume of distribution or total plasma clearance of antipyrine were observed with propoxyphene pretreatment. These results are in contrast to the reported impaired clearance of antipyrine by propoxyphene in man.

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Section: Discussionsupporting

confidence: 83%

“…Recently Chambers and Jefferson [6,7] have suggested that the antipyrine test carried out in rabbits is of value in studies of agents capable of altering oxidative drug metabolism. Thus the effect of propoxyphene on the elimination kinetics of antipyrine was examined in rabbits.…”

Section: Introductionmentioning

confidence: 99%

Absence of Effect of Propoxyphene on Antipyrine Kinetics in the Rabbit

Paxton¹

1983

Pharmacology

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“…NS = 0.05; **p < 0.01 vs. controls. Not significant; * p < tive of an inhibition of liver drug-metaboliz ing enzymes induced by tetanus vaccine [Chambers and Jefferson, 1982;André et al, 1984], Interestingly, the transient inhibitory influence of tetanus vaccine is consonant with previous investigations: Meredith et al [1985] noted a decreased rate of theophylline oxidation 1 day but not 7 days after in fluenza vaccination.…”

Section: Discussionmentioning

confidence: 57%

“…In order to test whether tetanus and ty phoid vaccines might impair liver drug-me tabolizing enzymes, their influence has been studied on pentobarbital-induced sleeping time in mice and antipyrine elimination in rabbits, both good indicators of hepatic drug metabolism [Chambers and Jefferson, 1982;André et al, 1984],…”

Section: Introductionmentioning

confidence: 99%

Influence of Tetanus and Typhoid Vaccines on Hepatic Drug Metabolism

Descotes

Guillermin²,

Evreux³

1988

Pharmacology

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Several experiments suggested that vaccines might inhibit liver drug-metabolizing enzymes, an assumption in agreement with other findings obtained with most immuno-enhancing agents. A direct, non-specific activation of macrophages with subsequent release of interleukin 1 may account for this inhibition. The purpose of the present study was to investigate whether tetanus and typhoid vaccines exerted such an influence on pentobarbital sleeping time in mice and antipyrine elimination in rabbits, both in vivo correlates of the activity of these enzymes. It is shown that tetanus (unlike typhoid) vaccination in both species can lead to a marked but transient impairment of hepatic drug metabolism in these conditions. The reason for this discrepancy is unclear. The assumption that aluminium hydroxide might play a critical role, as this adjuvant is included in the formulation of tetanus vaccine in contrast to that of typhoid vaccine, is not supported by our findings since aluminium hydroxide alone failed to exert any influence in our experimental conditions. Further studies are therefore warranted to elucidate the mechanism of this inhibition of the activity of hepatic drug-metabolizing enzymes.

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“…This latter type of interaction has been reported for a large number of drugs ranging from phenobarbitone with antipyrine (Chambers & Jefferson 1982), to cimetidine and warfarin (Serlin et al 1979). In the former case the clearance of the antipyrine was increased due to the induction of drug-metabolizing enzymes after pretreatment with phenobarbitone.…”

mentioning

confidence: 67%

The effect of intravenous pretreatment with small liposomes on the pharmacokinetics and metabolism of antipyrine in rabbits

Badiola

Al‐Angary

Halbert

1992

Journal of Pharmacy and Pharmacology

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The effect of intravenous pre-treatment with empty small liposomes on the pharmacokinetics and metabolism of antipyrine in rabbits has been investigated. The measured half-life of antipyrine was 104 min and the volume of distribution was 830 mL kg-1. The excretion of metabolites in a 24 h urine sample was measured, the main metabolite 4-hydroxyantipyrine was excreted to a level of 10% with the free drug accounting for 4%. The norantipyrine and 3-hydroxymethylantipyrine metabolites were excreted to a level of 8 and 7%, respectively. The intravenous administration of liposomes at a dose equivalent to 8 mg of egg yolk phosphatidylcholine daily for one week, had no significant effect on any of the measured pharmacokinetic parameters. The half-life after liposome treatment was 110 min and the volume of distribution was 790 mL kg-1, the metabolic pattern in the urine was also unaltered. The results suggest that the repeated administration of low doses of liposomes do not affect the pharmacokinetics and metabolism of antipyrine.

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Effects of Drug Pretreatment on Antipyrine Elimination in the Rabbit

Cited by 12 publications

References 15 publications

Absence of Effect of Propoxyphene on Antipyrine Kinetics in the Rabbit

Absence of Effect of Propoxyphene on Antipyrine Kinetics in the Rabbit

Influence of Tetanus and Typhoid Vaccines on Hepatic Drug Metabolism

The effect of intravenous pretreatment with small liposomes on the pharmacokinetics and metabolism of antipyrine in rabbits

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