Effects of doxorubicin mediated by gold nanoparticles and resveratrol in two human cervical tumor cell lines

Tomoaia, Gheorghe; Horovitz, Ossi; Mocanu, Aurora; NIŢĂ, A.; Avram, Alexandra; Rácz, Csaba; Şoriţău, Olga; Cenariu, Mihai; Tomoaia-Cotişel, Maria

doi:10.1016/j.colsurfb.2015.08.036

Cited by 54 publications

(26 citation statements)

References 42 publications

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“…The zeta potential (ZP) of CAO-AuNPs was determined to be −20 mV, indicating that the CAO-AuNPs had a high negatively charged surface, which could be beneficial for the delivery of positively charged drugs [2,35]. Moreover, it has been reported that the gold core is a double electron layer structure [36], which may explain the ready reduction of AuNPs by negatively charged carbohydrate.…”

Section: Resultsmentioning

confidence: 99%

Green Synthesis of Gold Nanoparticles Using Carrageenan Oligosaccharide and Their In Vitro Antitumor Activity

et al. 2018

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Gold nanoparticles (AuNPs) have been widely used in catalysis, photothermal therapy, and targeted drug delivery. Carrageenan oligosaccharide (CAO) derived from marine red algae was used as a reducing and capping agent to obtain AuNPs by an eco-friendly, efficient, and simple synthetic route for the first time. The synthetic conditions of AuNPs were optimized by response surface methodology (RSM), and the CAO-AuNPs obtained were demonstrated to be ellipsoidal, stable and crystalline by means of transmission electron microscopy (TEM), scanning electron microscopy (SEM) and X-ray diffraction (XRD). The CAO-AuNPs showed localized surface plasmon resonance (LSPR) oscillation at about 530 nm with a mean diameter of 35 ± 8 nm. The zeta potential of CAO-AuNPs was around −20 mV, which was related to the negatively charged CAO around AuNPs. The CAO-AuNPs exhibited significant cytotoxic activities to HCT-116 and MDA-MB-231 cells, which could be a promising nanomaterial for drug delivery.

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Section: Resultsmentioning

confidence: 99%

Green Synthesis of Gold Nanoparticles Using Carrageenan Oligosaccharide and Their In Vitro Antitumor Activity

et al. 2018

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“…These substrates showed good stability in cell culture, since a significant lost of scaffold material was not observed by dissolution in cellular medium during three weeks of experiments. The surface morphology of these substrates was examined by SEM and AFM [31][32][33][34][35][36][37][38]. Then, after the traditional sterilization in ethylene oxide [6,8] these substrates were investigated in cell culture for at least 21 days (21d).…”

Section: Preparation Of Hap and Hap-sr Multilayered Substratesmentioning

confidence: 99%

In vitro Response of Human Osteoblasts Cultured on Strontium Substituted Hydroxyapatites

Răpuntean¹,

Frangopol²,

Hodisan³

et al. 2019

Rev. Chim.

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The goal of this study was to analyze the response of osteoblasts cultured on strontium substituted hydroxyapatites (HAP-Sr) of well-defined high crystallinity deposited as thin films on glass plates. Up to now, this aspect has not been carefully investigated in the context of bio-ceramics. In this study, we present the osteoblasts activity on synthesized HAP-Sr for different amounts of strontium substitution for calcium within the hydroxyapatite (Ca10(PO4)6(OH)2, HAP) lattice, namely HAP-5%Sr, HAP-10%Sr, HAP-15%Sr and HAP-59.2%Sr (Sr-HAP, of formula Sr10(PO4)6(OH)2), in comparison with stoichiometric pure HAP, chosen as control. Each bio-ceramic was deposited as thin multilayers self-assembled substrate (scaffold) and chemically bonded to the surface of glass plates. These coatings revealed by AFM and SEM imaging a granular texture formed from bio-ceramic nanoparticles. They possessed a high degree of crystallinity, i.e. 68% to 86%, depending on the Sr amount within the HAP lattice, as judged by XRD. Osteoblasts were cultured up to 21days and displayed enhanced adhesion and proliferation particularly evidenced on relatively high strontium contents (especially 5 and 10 weight %, determined by SEM-EDX), where the alkaline phosphatase activity and type I collagen were strongly evidenced. These bio-ceramics showed a high in vitro biocompatibility stimulating the activity of osteoblasts in the process of bone formation. These nano biomaterials can have applications in orthopedic and dental surgery improving the osteointegration as coatings of bone implants as well as for bone repair and regeneration.

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“…Moreover, couple of studies [10,22] showed that 20 nm gold nanoparticles decrease cancer cells growth mouse model. AuNPs may also used as delivery agents for phytochemicals such as Gallic acid or chemotherapeutic agents such as doxorubicin can be used as replacement for cervical cancer therapy to decrease radiotherapy and chemotherapy side effects [14,28]. Retinoic acid loaded on gold nanoparticle showed promising anticervical cancer effect [30].…”

Section: Discussionmentioning

confidence: 99%

Gold Nanoparticles Targeting Human Cervical Cancer Cells

Merkadh¹,

Hameed²

2019

SIJOG

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The most disturbing gynecologic malignancies are cervical cancer particularly in the developing world with the same high incidence in Iraqi women. Cervical carcinoma has a high rate of mortality. The high death rate is associated with presence of human papillomavirus (HPV) infection. Cervical carcinoma is hard to treat, and conventional therapies are very aggressive which lead for the need for new approaches of therapy. Nanoparticles is a promising treatment modality to produce non-toxic and efficient cancer therapy. Gold nanoparticles (AuNPs) accumulate in cancer cells selectively. The current work was aimed to study cytotoxicity and cell death induced by AuNPs on cervical carcinoma cells. Methods: Cytotoxicity of AuNPs was assessed by MTT viability assay and analysed using multiple comparison ANOVA tests. Results: AuNPs nanoparticles from 12.5 up to 50 µg/mL for 72 hours showed concentration-dependent killing activity. Conclusion: Gold nanoparticles have anti-cervical carcinoma cells activity by cell death induction.

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Effects of doxorubicin mediated by gold nanoparticles and resveratrol in two human cervical tumor cell lines

Cited by 54 publications

References 42 publications

Green Synthesis of Gold Nanoparticles Using Carrageenan Oligosaccharide and Their In Vitro Antitumor Activity

Green Synthesis of Gold Nanoparticles Using Carrageenan Oligosaccharide and Their In Vitro Antitumor Activity

In vitro Response of Human Osteoblasts Cultured on Strontium Substituted Hydroxyapatites

Gold Nanoparticles Targeting Human Cervical Cancer Cells

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