Green Synthesis of Gold Nanoparticles Using Carrageenan Oligosaccharide and Their In Vitro Antitumor Activity

Abstract

Gold nanoparticles (AuNPs) have been widely used in catalysis, photothermal therapy, and targeted drug delivery. Carrageenan oligosaccharide (CAO) derived from marine red algae was used as a reducing and capping agent to obtain AuNPs by an eco-friendly, efficient, and simple synthetic route for the first time. The synthetic conditions of AuNPs were optimized by response surface methodology (RSM), and the CAO-AuNPs obtained were demonstrated to be ellipsoidal, stable and crystalline by means of transmission electron microscopy (TEM), scanning electron microscopy (SEM) and X-ray diffraction (XRD). The CAO-AuNPs showed localized surface plasmon resonance (LSPR) oscillation at about 530 nm with a mean diameter of 35 ± 8 nm. The zeta potential of CAO-AuNPs was around −20 mV, which was related to the negatively charged CAO around AuNPs. The CAO-AuNPs exhibited significant cytotoxic activities to HCT-116 and MDA-MB-231 cells, which could be a promising nanomaterial for drug delivery.

Gold Nanoparticles Using Ecklonia stolonifera Protect Human Dermal Fibroblasts from UVA-Induced Senescence through Inhibiting MMP-1 and MMP-3

“…The secondary metabolites of marine algae play an important role in the green synthesis of gold nanoparticles (GNPs) containing active substances with antioxidant properties. The green synthesis of GNPs could also be mediated by marine algae extracts containing molecules that serve as reducing, stabilizing, and capping agents [ 12 , 13 , 14 ]. GNPs have been used to treat a number of diseases by virtue of their biocompatibility and unique properties, such as conductivity, optical catalytic activity, and better structural characteristics than their bulk counterparts.…”

Green synthesis characterization and antimicrobial activity againstStaphylococcus aureusof silver nanoparticles using extracts of neem, onion and tomato

“…[16][17][18] The bactericidal activity of AgNPs depends not only on their size but also on the pH, salt concentration and the medium in which it is diffused. 19 Nano-silver's unique physical and chemical properties make it highly bioactive such that it can react with cells, microorganisms and macro-organisms. 14,20,21 The present work is based on a green synthesis of AgNPs using extracts of neem leaves (NE) alone and a mixture of neem, onion and tomato (NOT) at different pHs: pH 5, pH 7 and pH 9.…”

Biomedical Applications of Green Synthesized-Metallic Nanoparticles: A Review

“…Saratale et al [1] produced AgNPs using extract of Taraxacum officinale with elevated cytotoxic activity against human liver cancer cells (HepG2). In another report, AuNPs synthesized using carrageenan of marine red algae, displayed activities against HCT-116 and MDA-MB-231 cells [160].…”