Effects of dopamine on retinal and choroidal blood flow parameters in humans

Abstract

Aim: To investigate the effect of dopamine on retinal and choroidal blood flow in humans. Methods: We investigated the effect of two doses of intravenous dopamine (5 and 10 mg/kg/min) via a randomised double-masked crossover study in 12 healthy subjects chosen from a total of 16. Blood flow parameters in retina, optic nerve head and choroid were assessed with bi-directional laser Doppler velocimetry, laser Doppler flowmetry and laser interferometric measurement of fundus pulsation amplitude, respectively. Results: Intravenous dopamine dose-dependently increased retinal blood cell velocity and fundus pulsation amplitude (p,0.001). At the highest administered dose red blood cell velocity in retinal vessels increased by 37% and fundus pulsation amplitude by 24%. By contrast, optic nerve head blood flow did not change with dopamine administration. Conclusions: Our data indicate that dopamine has a pronounced enhancing effect on the retinal perfusion in humans. Further studies are required to establish the exact role of dopamine in the regulation of choroidal and optic nerve head blood flow.

Endothelial dysfunction in glaucoma

“…Nitric oxide has also been shown to play a role in the regulation of choroidal blood flow during isometric exercise (Luksch et al. 2003), light−dark transitions (Huemer et al. 2007) and in the flicker‐induced vasodilator response in the retina (Dorner et al.…”

Amblyopia Treatment Strategies and New Drug Therapies

“…95 According to Witkovsky, 97 dopamine is released by a unique set of amacrine cells and activates D1 and D2 dopamine receptors distributed throughout the retina, where it plays as a chemical messenger for light adaptation and multiple trophic capabilities. 96 These findings were supported by Huemer et al, 98,99 who indicated that dopamine has a distinct effect on retinal vessel diameters, which implies a role of dopamine in retinal blood flow hemodynamics. However, other studies 100,101 show that the effect of dopamine would take place mainly at the cortical level.…”

Molecular Mechanisms and Clinical Manifestations of Catecholamine Dysfunction in the Eye in Parkinson’s Disease As a Basis for Developing Early Diagnosis

“…Следующий наружный ядерный слой образован ядрами фоторецепторов, после которого следует наружный плексиформный слой, расположенный между наружным и внутренним ядерными слоями. [20][21][22] Радужка: адреналин, норадреналин, α 1адренорецепторы [26][27][28] Хрусталик: предшественник дофамина (ДОФА), β 2адренорецепторы [38][39][40] Цилиарное тело: [26,28,29] Слеза: адреналин, норадреналин, дофамин, метаболиты дофамина (ДОФУК, ГВК) [23][24][25] Влага: адреналин, норадреналин, дофамин, метаболит дофамина (ДОФУК) [19] Склера: D1-рецепторы к дофамину [30] Стекловидное тело: норадреналин, адреналин, дофамин, метаболит дофамина (ДОФУК) [31] Хориоидея: [32] Зрительный нерв: D1-и D2-рецепторы к дофамину [33,34] Сетчатка: адреналин, норадреналин, дофамин, α 1 -адренорецепторы, D1-и D2-рецепторы к дофамину [35][36][37] Рис. [14,18,46].…”

“…Практически во всех клетках сетчатки обнаружены рецепторы к дофамину [47,48]. Кроме того, ДА синтезируется во многих клетках сетчатки -фоторецепторах, амакриновых, биполярных, интерплексиформных и горизонтальных клетках [32,[35][36][37]49]. Наибольшее содержание ДА обнаружено в амакриновых клетках, которые участвуют в передаче импульса в горизонтальном направлении от биполярных клеток к амакриновым и далее к ганглионарным клеткам сетчатки [36,50].…”