Effects of dopamine on cellular and humoral immune responses in septic patients

Abstract

In vitro and in vivo studies have demonstrated that apart from its hemodynamic action dopamine can modulate immune responses. Dopamine reduces the synthesis of proinflammatory and induces the synthesis of anti-inflammatory mediators. Dopamine inhibits neurohormone synthesis, lymphocyte proliferation and platelet aggregation. It reduces the phagocytic activity of neutrophils and induces apoptosis. Particularly with regard to sepsis, where high serum dopamine levels are reached by enhanced endogenous production, exogenous application and impaired clearance, this immunomodulation may have a clinical impact. This review summarizes dopamine-mediated immunomodulating effects to advance the knowledge regarding dopamine as an immune regulator under septic conditions.

A New Sensor for Simultaneous Determination of Tyrosine and Dopamine Using Iron(III) Doped Zeolite Modified Carbon Paste Electrode

“…Tyrosin plays as a precursor for dopa, DA, thyroxin, noradrenalin and adrenalin as the hormone or NTM in mammalian central nervous systems. 7 Trace-level presentation of Tyr can modulate and control acetylcoline (Ach) receptors metabolic stability in muscle cells. 8 The high concentration of Tyr in culture medium results in increased sister chromatid exchange, while absence of Tyr could lead to impair of protein synthesis, thus it causes development imbalance in biological systems.…”

Fabrication of a novel enzymatic electrochemical biosensor for determination of tyrosine in some food samples

“…The content of Tyr in the body is correlated to the healthy state of the person [1,2]. Tyr is a precursor for thyroxin, dopa, dopamine, noradrenalin and adrenalin as the hormone or non-tuberculosis mycobacterial in central nervous systems [3]. Tyr can be made in the body of a person who receives enough amounts of phenylalanine.…”