Effects of domperidone on serum prolactin levels in human beings.

Abstract

Effects of domperidone, a dopaminergic antagonist, on serum prolactin levels were studied in 6 normal men and 6 normal cyclic women at the different phases of their menstrual cycles (i.e., the follicular, the preovulatory and the luteal phases). Domperidone (10 mg, i.v.) caused significant increases in serum prolactin in all cases within 15 min after the injection. The prolactin response was significantly (p<0.01) higher in women than in men, and there was no significant difference in the prolactin responses among the three phases of the menstrual cycles. These results indicate that domperidone may be an effective stimulator of serum prolactin secretion in human beings.

Hyperprolactinemia associated with psychotropics—a review

“…Quetiapine has a high affinity for serotonin 5HT2A receptors and lower affinity for dopamine D2 receptors. In addition, quetiapine appears to be selective for mesolimbic and mesocortical dopamine receptors, with relative sparing of TIDA system (Goldstein, 1999a). Quetiapine has a transient dopamine D2 occupancy and thus only temporarily elevates prolactin levels.…”

Rapid prolactin induction in adult male rats after treatment with diethylstilbestrol

“…Several drugs can increase serum PRL levels via various mechanisms, such as by decreasing DP, by increasing 5‐HT and by the potentiation of neurotransmitters such as VIP . Most medications that increase PRL act by inhibiting dopaminergic pathways and include DP receptor antagonists . Oestrogen acts directly and indirectly on the pituitary lactotrophs to stimulate PRL release.…”

Drugs and prolactin

“…These drugs cause hyperprolactinemia in over 50% of patients and commonly cause symptoms of amenorrhea and galactorrhea in women and erectile dysfunction in men [91][92][93]. Cisapride, another drug used to promote gastric emptying, does not block dopamine receptors and does not cause hyperprolactinemia.…”