Effects of dispersion of fiber orientation on the mechanical property of the arterial wall

Ren, Jiusheng

doi:10.1016/j.jtbi.2012.02.019

Cited by 7 publications

(6 citation statements)

References 26 publications

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“…Though intima with endothelium and base membrane has its distinct function, it is a very thin layer and mechanical often combined with the intima for mechanical analysis. Thus the arterial wall is often divided into two layers for mechanical analysis: Intima-media layer and the adventitia layer with distinct material properties (Bellini et al, 2014; Rachev, 1997; Ren, 2012; Wang et al, 2006; Yu et al, 1993). However, previous artery buckling analyses were limited to single-layered uniform arterial wall assumption (Han, 2009; Rachev, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…Canham and colleagues showed that in contrast to media layer, collagen fiber orientation was dispersed in intima and adventitia layers (Canham et al, 1989). The idealized perfectly aligned two fiber family model, though well captures the feature of collagen alignment in the mdia, it is limited in capturing the dispersed distribution of collagen fibers in the adventitia (Gasser et al, 2006; Ren, 2012). An improved model with dispersed collagen fiber distribution is needed to better capture the actual wall structure.…”

Section: Introductionmentioning

confidence: 99%

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Artery buckling analysis using a two-layered wall model with collagen dispersion

Mottahedi

Han

2016

Journal of the Mechanical Behavior of Biomedical Materials

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Artery buckling has been proposed as a possible cause for artery tortuosity associated with various vascular diseases. Since microstructure of arterial wall changes with aging and diseases, it is essential to establish the relationship between microscopic wall structure and artery buckling behavior. The objective of this study was to developed arterial buckling equations to incorporate the two-layered wall structure with dispersed collagen fiber distribution. Seven porcine carotid arteries were tested for buckling to determine their critical buckling pressures at different axial stretch ratios. The mechanical properties of these intact arteries and their intima-media layer were determined via pressurized inflation test. Collagen alignment was measured from histological sections and modeled by a modified von-Mises distribution. Buckling equations were developed accordingly using microstructure-motivated strain energy function. Our results demonstrated that collagen fibers disperse around two mean orientations symmetrically to the circumferential direction (39.02°±3.04) in the adventitia layer; while aligning closely in the circumferential direction (2.06°±3.88) in the media layer. The microstructure based two-layered model with collagen fiber dispersion described the buckling behavior of arteries well with the model predicted critical pressures match well with the experimental measurement. Parametric studies showed that with increasing fiber dispersion parameter, the predicted critical buckling pressure increases. These results validate the microstructure-based model equations for artery buckling and set a base for further studies to predict the stability of arteries due to microstructural changes associated with vascular diseases and aging.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Artery buckling analysis using a two-layered wall model with collagen dispersion

Mottahedi

Han

2016

Journal of the Mechanical Behavior of Biomedical Materials

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“…We found mean angles between the predicted cell orientation and the transverse plane of the arterial wall of ±56.6° (±0.8°) at the inner surface of the media and ±55.5° (±1.2°) and the outer surface of the adventitia, respectively. These computed orientations are to be compared with the experimental values of 51.2° and 40° used for the media and adventitia, respectively, in the modelling of the anisotropic structure of the arterial wall [ 23 ]. The underlying assumption in this statement is that the cellular orientation within a loaded structure may be strongly correlated with the anisotropy of the collagen network, as proposed in the literature [ 6 ].…”

Section: Resultsmentioning

confidence: 99%

“…The blood pressure has been estimated to 13 kPa (100 mm Hg, assumed to be the mean arterial pressure as proposed in similar studies [ 21 , 22 ]). The dimensions of the two layers were taken from [ 23 ]. Layers were considered to be isotropic linear elastic and nearly incompressible; the elastic modulus of the media was taken from [ 24 ], and the ratio between adventitia and media elastic properties was taken from [ 23 ].…”

Section: Methodsmentioning

confidence: 99%

“…The dimensions of the two layers were taken from [ 23 ]. Layers were considered to be isotropic linear elastic and nearly incompressible; the elastic modulus of the media was taken from [ 24 ], and the ratio between adventitia and media elastic properties was taken from [ 23 ]. The preferential cell directions were computed at the inner surface of the media and the outer surface of the adventitia following the above procedure.…”

Section: Methodsmentioning

confidence: 99%

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An Attempt to Predict the Preferential Cellular Orientation in Any Complex Mechanical Environment

2017

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Cells respond to their mechanical environment in different ways: while their response in terms of differentiation and proliferation has been widely studied, the question of the direction in which cells align when subject to a complex mechanical loading in a 3D environment is still widely open. In the present paper, we formulate the hypothesis that the cells orientate in the direction of unitary stretch computed from the right Cauchy-Green tensor in a given mechanical environment. The implications of this hypothesis are studied in different simple cases corresponding to either the available in vitro experimental data or physiological conditions, starting from finite element analysis results to computed preferential cellular orientation. The present contribution is a first step to the formulation of a deeper understanding of the orientation of cells within or at the surface of any 3D scaffold subject to any complex load. It is believed that these initial preferential directions have strong implications as far as the anisotropy of biological structures is concerned.

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Influence of atherosclerosis on anisotropy and incompressibility of the human thoracic aortic wall

Kozuń

Chwiłkowska

Pezowicz

et al. 2021

Biocybernetics and Biomedical Engineering

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Effects of dispersion of fiber orientation on the mechanical property of the arterial wall

Cited by 7 publications

References 26 publications

Artery buckling analysis using a two-layered wall model with collagen dispersion

Artery buckling analysis using a two-layered wall model with collagen dispersion

An Attempt to Predict the Preferential Cellular Orientation in Any Complex Mechanical Environment

Influence of atherosclerosis on anisotropy and incompressibility of the human thoracic aortic wall

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