Effects of dimethoate in male mice reproductive parameters

Jallouli, Manel; Dhouib, Ines Bini; Dhouib, Hanène; Gharbi, N.; Fazâa, Saloua El

doi:10.1016/j.yrtph.2015.10.010

Cited by 17 publications

(11 citation statements)

References 30 publications

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“…In our study, MDA levels significantly increased, while SOD and GPx activities significantly decreased after dimethoate administration. The same is true for semen parameter findings, which support earlier dimethoate reports ( 3 , 4 , 5 ). Jallouli et al ( 5 ) reported a significant drop in sperm concentration, motility, viability, and antioxidant enzyme activities and a significant rise in abnormal-shaped spermatozoa and LPO level in dimethoate-treated mice.…”

Section: Discussionsupporting

confidence: 91%

“…The same is true for semen parameter findings, which support earlier dimethoate reports ( 3 , 4 , 5 ). Jallouli et al ( 5 ) reported a significant drop in sperm concentration, motility, viability, and antioxidant enzyme activities and a significant rise in abnormal-shaped spermatozoa and LPO level in dimethoate-treated mice. Ben Abdallah et al ( 3 ) observed that dimethoate concentrations of 50, 100, and 200 μmol/L caused significant oxidative injury in spermatozoa, accompanied with increased MDA levels, and significantly lower sperm motility, viability, and SOD, CAT, and GPx activities.…”

Section: Discussionsupporting

confidence: 91%

“…Dimethoate is a widely used organophosphorus insecticide, toxic to vertebrates when taken by ingestion, inhalation, and dermal absorption ( 1 , 2 ). It may cause reproductive toxicity, including low sperm count, sperm motility, blood testosterone, testis weight, and fertility and may lead to abnormal sperm development ( 3 , 4 , 5 ). It causes cellular injury and oxidative stress by overgeneration of reactive radicals and stimulation of lipid peroxidation (LPO) ( 6 ).…”

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confidence: 99%

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Cherry laurel fruit extract counters dimethoate-induced reproductive impairment and testicular apoptosis

Sarıözkan

Endirlik

Kılıç³

et al. 2020

Archives of Industrial Hygiene and Toxicology

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Dimethoate is an organophosphorus pesticide used against agricultural insects, which causes oxidative stress and damage in many organs, including the reproductive ones. Cherry laurel (Laurocerasus officinalis Roem.) fruit is rich in vitamins and phenolic compounds with antioxidant effect. The aim of this study was to investigate how effective its extract would be against dimethoate-induced testis and sperm damage in rats. Sixty animals were divided in six groups of 10. Group 1 (control) received only 1 mL of saline (0.9 % NaCl). Group 2 received 7 mg/kg of dimethoate in 1 mL of saline. Group 3 received 4 mg/kg of extract in 1 mL of saline. Group 4 received the extract 30 min before dimethoate administration. Group 5 received vitamin C (positive control, 100 mg/kg in 1 mL of saline) 30 min before dimethoate administration. Group 6 received only dimethoate for the first four weeks and then a combination of dimethoate and extract for another four weeks. All doses were administered daily by oral gavage. After eight weeks of treatment, the rats were euthanised and their reproductive organs removed. We took their body and reproductive organ weights and evaluated testicular oxidative stress, semen characteristics, sperm DNA damage, testicular apoptosis, and histopathological changes. Dimethoate significantly decreased body and reproductive organ weights, sperm motility and concentration, testicular superoxide dismutase, and glutathione-peroxidase activities and significantly increased lipid peroxidation, abnormal sperm rate, sperm DNA damage, testicular apoptosis, and caused histopathological lesions. Cherry laurel extract significantly countered many dimethoate-induced adverse effects, both as pre- and post-treatment, including reproductive organ weight, semen parameters, oxidant-antioxidant balance, sperm DNA integrity, testicular apoptosis, and histological structure. Our findings clearly suggest that the beneficial effects of the extract are associated with countering oxidative stress, lipid peroxidation in particular.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

mentioning

confidence: 99%

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Cherry laurel fruit extract counters dimethoate-induced reproductive impairment and testicular apoptosis

Sarıözkan

Endirlik

Kılıç³

et al. 2020

Archives of Industrial Hygiene and Toxicology

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“…On the other hand, observations made in groups of rats exposed to dimethoate gavage show a slight decrease in body weight for both sexes males and females, as shown in Figure 3 and Figure 4. Our results are in line with the works of Jallouli on mice poisoned by the diméthoate [15].…”

Section: Effect Of Dimethoate On Body Weightsupporting

confidence: 92%

Effect of Dimethoate on Object Recognition Memory in Wistar Rats and Essay of Treatment with Nettle

Samih¹,

N’Go²,

Belaaouja³

et al. 2017

JBBS

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Pesticides were economically important chemicals in agriculture. Their use has permitted agricultural progress, through the eradication of harmful insect and the fight against vectors of disease. However, several studies question the beneficial effects of organophosphorus compounds, showing that their deregulated use causes various problems of environmental pollution and human health. The present study shows that chronic exposure to a subtoxic dose of dimethoate is likely to affect cognitive and behavioral functions of rats (both males and females). Our results show that exposure to dimethoate affects both short and long-term memory capacities. The short-term memory results are more pronounced. Treatment with nettle extract allowed a significant improvement in cognitive and behavioral performance of the rats after their exposure to dimethoate.

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“…A significant decrease in weight was also recorded Figure 1. These results are in perfect agreement with Jallouli's work on mice intoxicated by Dimethoate [20].…”

Section: Systemic Effects Of Chronic Exposure To Dimethoatesupporting

confidence: 91%

Effects of Dimethoate Exposure on Locomotor Activity and Anxiety-Like Behavior in Female Wistar Rat

Samih¹,

N’Go²,

Belaaouja³

et al. 2017

JBBS

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Developmental exposure to organophosphate insecticide is well known to induce neurobehavioral impairments, at late period. The present study aims to investigate the effects of subchronic exposure to Dimethoate, on locomotors skills and anxiety like behavior among wistar rat. Two groups of female's rats are used. The intoxicated group receives daily, during five weeks, by intragastric gavage, a dose of Dimethoate dissolved in corn oil (100 mg/kg body weight). The control group receives only the corn oil. Spontaneous locomotors activity is evaluated using the Open Field test (OF) and anxiety-like behavior is measured using Elevated Plus-Maze (EPM). Dimethoate induced significant impairment of spontaneous locomotors activities, which is reflected by high decrease of number of squares crossed (SC) in OF. Females exposed to Dimethoate develop further anxiety-like response, expressed by significant reductions of the time spent in open arm of Elevated Plus-Maze.

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Effects of dimethoate in male mice reproductive parameters

Cited by 17 publications

References 30 publications

Cherry laurel fruit extract counters dimethoate-induced reproductive impairment and testicular apoptosis

Cherry laurel fruit extract counters dimethoate-induced reproductive impairment and testicular apoptosis

Effect of Dimethoate on Object Recognition Memory in Wistar Rats and Essay of Treatment with Nettle

Effects of Dimethoate Exposure on Locomotor Activity and Anxiety-Like Behavior in Female Wistar Rat

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