Effect of Dimethoate on Object Recognition Memory in Wistar Rats and Essay of Treatment with Nettle

Abstract

Pesticides were economically important chemicals in agriculture. Their use has permitted agricultural progress, through the eradication of harmful insect and the fight against vectors of disease. However, several studies question the beneficial effects of organophosphorus compounds, showing that their deregulated use causes various problems of environmental pollution and human health. The present study shows that chronic exposure to a subtoxic dose of dimethoate is likely to affect cognitive and behavioral functions of rats (both males and females). Our results show that exposure to dimethoate affects both short and long-term memory capacities. The short-term memory results are more pronounced. Treatment with nettle extract allowed a significant improvement in cognitive and behavioral performance of the rats after their exposure to dimethoate.

Neuroprotective effects of Clitoria ternatea L. against propionic acid-induced behavior and memory impairment in autistic rat model

“…After a postponement of 24 h, the rats were again positioned in the device, but this time, one of the two identical objects was replaced by another entirely different (B). The animal is permitted to explore the two different objects for 5 min [13,14].…”

“…Recognition index =time spent in discovering the object B /Sigma time spent exploring objects A and B [13]. All the values in the tabular column represent the Mean ± SD (Standard deviation), n = 6 (6 rats in each group).…”