Effects of different wavelengths of low-level laser therapy on orthodontically induced inflammatory root resorption in rats investigated with micro–computerized tomography

Keklikci, Hasibe Baser; Yağcı, Ahmet

doi:10.1016/j.ajodo.2020.10.020

Cited by 4 publications

(5 citation statements)

References 33 publications

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“…In the current study, an energy density of 8 J/cm 2 has been used, which is similar to that employed by Yousry et al [ 35 ], as well as Goymen and Gulec [ 24 ]. By reviewing the literature, a wide range of energy density values have been documented with laser administration, where several authors used lower energy doses such as 3.6 J/cm 2 [ 22 ], and 4.8 J/cm 2 [ 16 , 21 ], and others used higher doses such as 54 J/cm 2 [ 36 ], and 75 J/cm 2 [ 20 ]. In the present work, the administered laser energy dose was 8 J/cm 2 , delivered through a single application of 8 s against the maxillary canine root, dispensing a beam spot size of 1 cm 2 using the flat top handpiece.…”

Section: Discussionmentioning

confidence: 99%

The influence of two photobiomodulation protocols on orthodontically induced inflammatory root resorption (a randomized controlled clinical trial)

et al. 2022

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Background Controversial results have been reported regarding the impact of photobiomodulation (PBM) on orthodontically induced inflammatory root resorption (OIIRR). The aim of this study was to evaluate the influence of two PBM protocols, one of them requiring a high application frequency (on days 0, 3, 7, 14, then every 2 weeks), while the second requires less frequent applications (every 3 weeks), on OIIRR accompanying orthodontic treatment. Methods Twenty female patients were recruited for this randomized controlled trial, requiring the therapeutic extraction of maxillary first premolars, and they were randomly divided into 2 equal groups. In Group A, one side of the maxillary arch randomly received PBM on days 0, 3, 7, 14, and every 2 weeks thereafter, while in Group B, one side was randomly chosen to receive PBM every 3 weeks. The laser applied was a Diode laser with a wavelength of 980 nm, in a continuous mode. Canine retraction in both groups was carried out using closed-coil springs, delivering 150 g of force, and the force level was checked every 3 weeks, over a 12-week study period. Pre-retraction and post-retraction cone-beam computed tomography (CBCT) was done for the evaluation of OIIRR. Results No significant differences in the amount of OIIRR have been reported between the laser and control sides in both groups A and B. Also, no significant differences have been reported between the laser sides in both groups. Conclusions Photobiomodulation does not affect OIIRR, whether by increasing or decreasing its occurrence, with both laser application protocols. Therefore, it can be stated that PBM does not result in root resorption less than the commonly observed range elicited with conventional orthodontic treatment, and that it has no effect on OIIRR. Trial registration Two Low-level Laser Irradiation Protocols on the Rate of Canine Retraction (NCT04926389), 15/06/2021—retrospectively registered. https://clinicaltrials.gov/ct2/show/NCT04926389.

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Section: Discussionmentioning

confidence: 99%

The influence of two photobiomodulation protocols on orthodontically induced inflammatory root resorption (a randomized controlled clinical trial)

et al. 2022

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“…Moreover, PBM therapy provides a more precise scope of action compared to pulsed electromagnetic fields. Furthermore, PBM therapy possesses strong controllability, as different light parameters can lead to varying outcomes [42][43][44], allowing for personalized adjustments based on specific circumstances and patient responses [156]. Also, PBM therapy does not cause tissue damage, inflammation, or infection; instead, it may provide relief from these conditions [160].…”

Section: Comparison Between Pbm and The Other Methods In Otmmentioning

confidence: 99%

“…Despite these advantages, PBM therapy also has some limitations. The efficacy of PBM therapy in OTM may vary among individuals and there is a lack of standardized protocols regarding the optimal light parameters for PBM therapy [42][43][44], which makes it challenging to establish uniform treatment guidelines and contributes to variations in treatment outcomes. Additionally, although some studies have investigated the effects of PBM therapy in orthodontics, the existing evidence on the efficacy of PBM therapy in orthodontic tooth movement is limited, and further high-quality studies, especially well-designed RCTs, are needed to confirm its benefits and limitations in clinical practice.…”

Section: Comparison Between Pbm and The Other Methods In Otmmentioning

confidence: 99%

“…It also displayed more molar mesialization than other wavelengths [42,43]. Keklikci et al [44] also compared the effect of 405 nm, 532 nm, 650 nm, and 940 nm light on OIIRR. The results showed all wavelengths could inhibit root resorption and decrease the number of lacunae except 405 nm light because of its limited penetration depth in tissue.…”

Section: The Efficacy Of Pbm Therapy On Otm In Cell and Animal Experi...mentioning

confidence: 99%

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The Effects and Mechanisms of PBM Therapy in Accelerating Orthodontic Tooth Movement

et al. 2023

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Malocclusion is one of the three major diseases, the incidence of which could reach 56% of the imperiled oral and systemic health in the world today. Orthodontics is still the primary method to solve the problem. However, it is clear that many orthodontic complications are associated with courses of long-term therapy. Photobiomodulation (PBM) therapy could be used as a popular way to shorten the course of orthodontic treatment by nearly 26% to 40%. In this review, the efficacy in cells and animals, mechanisms, relevant cytokines and signaling, clinical trials and applications, and the future developments of PBM therapy in orthodontics were evaluated to demonstrate its validity. Simultaneously, based on orthodontic mechanisms and present findings, the mechanisms of acceleration of orthodontic tooth movement (OTM) caused by PBM therapy were explored in relation to four aspects, including blood vessels, inflammatory response, collagen and fibers, and mineralized tissues. Also, the cooperative effects and clinical translation of PBM therapy in orthodontics have been explored in a growing numbers of studies. Up to now, PBM therapy has been gaining popularity for its non-invasive nature, easy operation, and painless procedures. However, the validity and exact mechanism of PBM therapy as an adjuvant treatment in orthodontics have not been fully elucidated. Therefore, this review summarizes the efficacy of PBM therapy on the acceleration of OTM comprehensively from various aspects and was designed to provide an evidence-based platform for the research and development of light-related orthodontic tooth movement acceleration devices.

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“…Same as previous research, the assessment of OIIRR was measured by micro-CT. 40,41 The detection was performed on the coronal plane slice of the mesial root of the maxillary rst molar. The outer and inner boundaries of the mesial root were determined from the cementoenamel junction to the root apex (Fig.…”

Section: Assessment Of Oiirrmentioning

confidence: 99%

A sustained-release Trametinib bio-multifunction hydrogel inhibits orthodontically induced inflammatory root resorption

Bao

et al. 2022

RSC Adv.

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Effects of different wavelengths of low-level laser therapy on orthodontically induced inflammatory root resorption in rats investigated with micro–computerized tomography

Cited by 4 publications

References 33 publications

The influence of two photobiomodulation protocols on orthodontically induced inflammatory root resorption (a randomized controlled clinical trial)

The influence of two photobiomodulation protocols on orthodontically induced inflammatory root resorption (a randomized controlled clinical trial)

The Effects and Mechanisms of PBM Therapy in Accelerating Orthodontic Tooth Movement

A sustained-release Trametinib bio-multifunction hydrogel inhibits orthodontically induced inflammatory root resorption

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