Effects of different Lactobacillus reuteri on inflammatory and fat storage in high-fat diet-induced obesity mice model

Gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis

“…The presence of a population of neomycin-sensitive gut bacteria and its association with obesity-related traits (figure 4D) suggests a potential beneficial interplay between these bacteria and energy regulation and metabolism. In the present study, H1 treatment did not affect the level of known commensal bacteria that possess anti-obesogenic properties, such as A. muciniphila ,23 56 L. reuteri 57 or L. johnsonii 58 (figure 4C). Further study of the functional gut microbiota and examination of their mechanism of action will be required to identify new strategies to prevent and treat obesity and related metabolic disorders 59…”

High-fat-diet–induced obesity is associated with decreased antiinflammatory Lactobacillus reuteri sensitive to oxidative stress in mouse Peyer's patches

“…We recently found that oral administration of L3 prevented HFD induce obesity and low grade chronic inflammation in mice [45], demonstrating the importance of this specific commensal phenotype keep intestine immune homeostasis. Similar strain should be isolated and identified by comparing Lactobacillus reuteri composition in obese and lean human or gut microbiota humanized animal.…”

Current evidence on the use of probiotics in liver diseases

“…Several studies have reported on the role of the gut microbiota in energy production and fat storage (Qiao et al, 2015). In an animal study, compared with normal mice, germ-free mice with no gut microbiota had 42% less body fat despite consuming more food (Backhed et al, 2004).…”

“…possess more diverse enzymes capable of digesting and extracting calories from complex polysaccharides . It is important to mention that bacterial strains of the same species could possess different effects on inflammatory and obesity (Qiao et al, 2015); however the causality of this relationship is still a debate. Nonalcoholic fatty liver disease (NAFLD) includes a spectrum of conditions that go from isolated steatosis to active lesions with inflammation, a condition named NASH, which can cause cirrhosis and hepatocellular carcinoma.…”