Effects of Different Exercise Modalities on Fatigue in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Year-long Randomised Controlled Trial

Taaffe, Dennis R.; Newton, Robert U.; Spry, Nigel; Joseph, David; Chambers, Suzanne K.; Gardiner, Robert A.; Wall, Bradley A; Cormie, Prue; Bolam, Kate A.; Galvão, Daniel A.

doi:10.1016/j.eururo.2017.02.019

Cited by 116 publications

(132 citation statements)

References 26 publications

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“…Resistance training scored better in increasing cardiovascular fitness than aerobic [17,18]. Four studies found a significant improvement on cardiovascular fitness after physical exercises, measured by different tests [13,26,29,35].…”

Section: Blood Biomarkersmentioning

confidence: 99%

The effectiveness of lifestyle interventions to reduce side effects of androgen deprivation therapy for men with prostate cancer: a systematic review

2019

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Purpose The aim of this review is to systematically review randomized controlled trials on lifestyle interventions on PCa patients undergoing androgen deprivation therapy. Methods A literature search was conducted using the electronic databases Medline and PubMed. To be eligible, studies had to be randomized controlled trials (RCTs) that focused on side effects of ADT and lifestyle interventions to reduce side effects for men undergoing ADT with PCa. Lifestyle interventions were defined as interventions that included any dietary or behavioral components. Results Twenty-nine trials were included. Most of them focused on exercise interventions, while some investigated the effect of dietary or behavioral interventions. The effect of different lifestyle influencing modalities aimed to improve on the adverse effects of ADT varied greatly. Conclusions It is not possible to draw one conclusion on the effect of exercise-based interventions, but noted on several adverse effects of ADT improvement. Further studies are necessary to develop personalized lifestyle interventions in order to mitigate the adverse effects.

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Section: Blood Biomarkersmentioning

confidence: 99%

The effectiveness of lifestyle interventions to reduce side effects of androgen deprivation therapy for men with prostate cancer: a systematic review

2019

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“…Men with prostate cancer could improve their strength, physical functioning, and cardiovascular health by increasing their physical activity. 80,81 Finally, physical exercise significantly improves QoL, although it is not entirely clear whether it affects metabolic risk factors in patients with androgen deprivation therapy-treated prostate cancer.…”

Section: Adt and The Risk Of Cardiovascular Diseasementioning

confidence: 99%

Adverse effects of androgen deprivation therapy in patients with prostate cancer: focus on metabolic complications

Tzortzis

Samarinas

Zachos

et al. 2017

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Prostate cancer is the most common cancer among men and androgen deprivation therapy (ADT) is the most effective treatment for this disease. The cornerstone of the treatment of prostate cancer is inhibition of testosterone production which interrupts testosterone-induced growth of the prostate tumor. The dramatic decrease in testosterone levels, however, has several undesirable effects on the metabolic profile and bone metabolism and can also lead to fatigue, loss of libido, gynecomastia, and anemia, provoke vasomotor flushing, and generally affect the quality of life. Due to the long-term survival rates of patients with prostate cancer, treatmentrelated adverse effects are highly relevant and thus, in each clinical setting, the benefits of ADT must be weighed against treatment-related adverse effects. The current review focuses on the more recently described metabolic complications of androgen deprivation therapy, including obesity, diabetes, lipid alterations, metabolic syndrome, and cardiovascular disease. In addition, it provides practical management recommendations drawn from the available guidelines issued

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“…Most randomized controlled trials (RCTs) in exercise oncology have only compared aerobic exercise with usual care, strength exercise to usual care, or combined exercise to usual care . A small number of exercise oncology RCTs have compared aerobic with strength exercise or compared combined exercise with aerobic only or strength only, but we are unaware of any exercise oncology trial that has conducted a full factorial comparison of exercise modality (ie, combined exercise, aerobic only, strength only, and usual care). Consequently, it is unknown what single or combined exercise modality is optimal for QoL in cancer survivors.…”

Section: Introductionmentioning

confidence: 99%

Modality‐specific exercise guidelines and quality of life in kidney cancer survivors: A cross‐sectional study

et al. 2018

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Effects of Different Exercise Modalities on Fatigue in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Year-long Randomised Controlled Trial

Abstract: We compared the effects of different exercise modes on fatigue in men on androgen deprivation therapy. All exercise programs reduced fatigue and enhanced vitality. We conclude that undertaking some form of exercise will help reduce fatigue, especially in those who are the most fatigued.

Cited by 116 publications

References 26 publications

The effectiveness of lifestyle interventions to reduce side effects of androgen deprivation therapy for men with prostate cancer: a systematic review

The effectiveness of lifestyle interventions to reduce side effects of androgen deprivation therapy for men with prostate cancer: a systematic review

Adverse effects of androgen deprivation therapy in patients with prostate cancer: focus on metabolic complications

Modality‐specific exercise guidelines and quality of life in kidney cancer survivors: A cross‐sectional study

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