The effectiveness of lifestyle interventions to reduce side effects of androgen deprivation therapy for men with prostate cancer: a systematic review

Abstract

Purpose The aim of this review is to systematically review randomized controlled trials on lifestyle interventions on PCa patients undergoing androgen deprivation therapy. Methods A literature search was conducted using the electronic databases Medline and PubMed. To be eligible, studies had to be randomized controlled trials (RCTs) that focused on side effects of ADT and lifestyle interventions to reduce side effects for men undergoing ADT with PCa. Lifestyle interventions were defined as interventions that included any dietary or behavioral components. Results Twenty-nine trials were included. Most of them focused on exercise interventions, while some investigated the effect of dietary or behavioral interventions. The effect of different lifestyle influencing modalities aimed to improve on the adverse effects of ADT varied greatly. Conclusions It is not possible to draw one conclusion on the effect of exercise-based interventions, but noted on several adverse effects of ADT improvement. Further studies are necessary to develop personalized lifestyle interventions in order to mitigate the adverse effects.

Effects of leuprolide acetate on the quality of life of patients with prostate cancer: A prospective longitudinal cohort study

“…To improve the QOL of patients receiving ADT, it is important to conduct routine screening to identify fatigue in patients. 21 In our study, the dyspnea scale score increased by 13 points over 12 months compared with the pretreatment values. The mechanism underlying dyspnea in patients with cancer is not well understood due to the heterogeneous origins of shortness of breath.…”

Randomised controlled trial to investigate the effectiveness of the symptom management after radiotherapy (SMaRT) group intervention to ameliorate lower urinary tract symptoms in men treated for prostate cancer

“…Diepernick et al (37) in a follow-on study found that that pelvic floor muscle strength of men in their intervention study diminished over the 3 years post-intervention but that men still had better LUTS than men in their control group. The evidence for lifestyle interventions for reducing PCa treatment adverse effects is growing [38,39]. Furthermore, whilst a recent systematic review [40] has classified the important components of benign LUTS self-management, the active components or behavioural interventions that contribute to these are far from clear.…”

“…The evidence for lifestyle interventions for reducing PCa treatment adverse effects is growing [ 38 , 39 ]. Furthermore, whilst a recent systematic review [ 40 ] has classified the important components of benign LUTS self-management, the active components or behavioural interventions that contribute to these are far from clear.…”

Self‐reported lack of energy or feeling depressed 12 months after treatment in men diagnosed with prostate cancer within a population‐based registry

“…It should be noted that these interventions may have potential adverse effects such as increased anxiety, so the patient should still be monitored appropriately as with other interventions 24 . Vigorous monitored exercise is particularly effective in treating the side effects of ADT in men with metastatic disease 25 . It is also important to consider the experience of partners, who can suffer profound depression and anxiety because of a PCa diagnosis in a loved one and may need assistance in identifying depression or anxiety and accessing appropriate care.…”

“…24 Vigorous monitored exercise is particularly effective in treating the side effects of ADT in men with metastatic disease. 25 It is also important to consider the experience of partners, who can suffer profound depression and anxiety because of a PCa diagnosis in a loved one and may need assistance in identifying depression or anxiety and accessing appropriate care. It may be appropriate for individual patients and couples to be referred for psychosexual therapy and sexual rehabilitation.…”