Effects of Different Environmental Factors and Virulence Factors, dupA and iceA Genes, of Helicobacter pylori on Peptic Ulcer

Babaei, Vahid; Saghaei, Yassaman; Gohardani, Hamidreza Zeraatgar; Vali, Farzaneh; Teimourian, Shahram

doi:10.5812/jjm.40161

Cited by 3 publications

(3 citation statements)

References 28 publications

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“…Only one isolate from a nonulcer dyspepsia patient yielded both iceA1 and iceA2 in the PCR product. Babaei et al [91] have confirmed that there is a strong relationship between duodenal ulcer and the genotypes of iceA1 (+)/ iceA2 (−) [91]. The study identified a 61% iceA1 (+) /iceA2 (−) prevalence in peptic ulcer patients and 17.6% prevalence of this genotype for H. pylori infected nonpeptic ulcer disease patients.…”

Section: Resultsmentioning

confidence: 68%

“…Tobacco usage has also been reported to be a dependent ulcerogenic risk factor for the development of gastroduodenal disorders including peptic ulcers and cancers of the GI tract [91]. Smoking acts indirectly in the promotion of gastroduodenal conditions by adversely affecting the mucosal protective mechanisms of the GI tract and also increasing the risk of H. pylori infection [92].…”

Section: Resultsmentioning

confidence: 99%

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Helicobacter pyloriInfection, Virulence Genes’ Distribution and Accompanying Clinical Outcomes: The West Africa Situation

Ofori

Adinortey

Bockarie

et al. 2019

BioMed Research International

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Data on Helicobacter pylori (H. pylori) infection and virulence factors in countries across West Africa are scattered. This systematic review seeks to present an update on the status of H. pylori infection focusing on prevalence rate, distribution of virulent genes, and their link to clinical outcomes across countries in the western part of Africa. This information is expected to broaden the knowledge base of clinicians and researchers regarding H. pylori infection and associated virulence factors in West African countries. Search Method. A comprehensive search of the scientific literature in PubMed and ScienceDirect was conducted using the search terms including “Helicobacter pylori infection in West Africa”. Databases were sourced from January 1988 to December 2018. Results. Data on the incidence of H. pylori infection and related pathological factors were found for some countries, whereas others had no information on it. Smoking, alcohol, exposure to high levels of carcinogens and diet were reported to be involved in the pathogenesis of gastroduodenal diseases and gastric cancer. Besides the environmental factors and genetic characteristics, there are important characteristics of H. pylori such as the ability to infect, replicate, and persist in a host that have been associated with the pathogenesis of various gastroduodenal diseases. Concluding Remarks. This systematic search has provided information so far available on H. pylori virulence factors and clinical outcomes in West Africa. Accordingly, this piece has identified gaps in the body of knowledge highlighting the need for more studies to clarify the role of H. pylori virulence factors and associated clinical outcomes in the burden of this bacterial infection in West Africa, as data from these countries do not give the needed direct relation.

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Section: Resultsmentioning

confidence: 68%

Section: Resultsmentioning

confidence: 99%

Helicobacter pyloriInfection, Virulence Genes’ Distribution and Accompanying Clinical Outcomes: The West Africa Situation

Ofori

Adinortey

Bockarie

et al. 2019

BioMed Research International

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“…Babaei et al [19] revealed a strong correlation of iceA with PUD (P < 0.05). This correlation also supported our findings since we also established greater rates of PUD among patients with iceA strain.…”

Section: Discussionmentioning

confidence: 92%

Association of dupA, iceA, homB Genes of Helicobacter pylori with Gastritis, Peptic Ulcer Disease and Gastric Cancer

Bajwa

Idrees²,

Maheshwari

2020

JPRI

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Objective: To determine the association of dupA, iceA, homB genes of Helicobacter pylori with gastro-duodenal diseases such as gastritis, peptic ulcer disease PUD and gastric cancer. Materials and Methods: This cross-sectional analytical study was conducted at Gastroenterology Department, Shaikh Zayed Hospital Lahore. Patients with gastro-duodenal diseases and positive H. pylori were included. Gastric biopsies were taken from fundus, body and antrum. H. pylori DNA were removed utilizing Gentra DNA extraction Kit (Life Technologies, USA) as per the technique and Qualitative PCR for the recognition of H. Pylori DNA. The PCR primers sets were designed for the specific detection of dupA, iceA and homB genes of H. pylori. All the data was recorded in proforma and analyzed by SPSS version 20. Results: Mean age of the cases was 41.22+8.04 years. Males were more affected 118(60.2%). HomB was the most common 76(38.8%) followed by dupA and iceA 28.6% and 24.5% respectively. Peptic ulcer disease and gastritis were higher among patients having dup A and iceA positive strains as compared to homB gene patients, while gastric cancer was significantly higher among HomB gene infected patients, p-values were quite significant. Conclusion: It was concluded that homB gene was most frequent in H. pylori infected population. Peptic ulcer disease and gastritis are markedly associated with dupA and iceA genes, while homB gene infected patients are at high risk of gastric cancer.

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A systematic review and meta-analysis of outcomes of infection with Helicobacter pylori dupA+ strains in Iranian patients

et al. 2020

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Effects of Different Environmental Factors and Virulence Factors, dupA and iceA Genes, of Helicobacter pylori on Peptic Ulcer

Cited by 3 publications

References 28 publications

Helicobacter pyloriInfection, Virulence Genes’ Distribution and Accompanying Clinical Outcomes: The West Africa Situation

Helicobacter pyloriInfection, Virulence Genes’ Distribution and Accompanying Clinical Outcomes: The West Africa Situation

Association of dupA, iceA, homB Genes of Helicobacter pylori with Gastritis, Peptic Ulcer Disease and Gastric Cancer

A systematic review and meta-analysis of outcomes of infection with Helicobacter pylori dupA+ strains in Iranian patients

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