Effects of different classes of pesticides on pentobarbital anesthesia and toxicity in Japanese quail

Abstract

The substance isolated from feed extracts and authentic TUA had identical R f values in a number of solvent systems, and both were hydrolyzed under autoclave conditions to yield similar ratios of tylosin and desmycosin as a function of pH. In addition, controlled regeneration of both substances at constant p H and different temperatures yielded equivalent rate constants. SLMMARYThe evidence presented in this report indicates that tylosin reacts with urea to form a n antimicrobially inactive compound, which has been identified as TUA. The formation of TUA does not represent an actual loss of available tylosin.Elucidation of this reversible tylosin-urea reaction affords the opportunity to investigate the application of TUA as a stabilized form of tylosin in urea-containing mixtures. Investigation is continuing to determine if TUA would be a useful therapeutic agent for ruminant production and management. The results of on-station and feedlot experience with TUA in cattle, as well as in vitro and in uico hydrolysis and rumen function data, will be reported elsewhere.