Effects of Different Anesthetic Methods on Cellular Immune and Neuroendocrine Functions in Patients With Hepatocellular Carcinoma Before and After Surgery

Sun, Huizhen; Song, Yonggui; Wang, Xiangyun

doi:10.1002/jcla.22000

Cited by 35 publications

(27 citation statements)

References 38 publications

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“…The advanced concept of surgery, anesthesia, infusion, heat preservation, and analgesia during the operation reflect the superiority of ERAS programs. The combined anesthesia can reduce surgical stress and relieve postoperation pain very well . The minimally invasive surgery can reduce surgical trauma, but the good exposure of the surgical field and accurate completion of the surgical procedure should be considered first .…”

Section: Discussionmentioning

confidence: 99%

Safety and efficacy of enhanced recovery after surgery (ERAS) programs in patients undergoing hepatectomy: A prospective randomized controlled trial

Chen

Cao

et al. 2018

Clinical Laboratory Analysis

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Section: Discussionmentioning

confidence: 99%

Safety and efficacy of enhanced recovery after surgery (ERAS) programs in patients undergoing hepatectomy: A prospective randomized controlled trial

Chen

Cao

et al. 2018

Clinical Laboratory Analysis

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“…HCC progression can be attributed to a series of complex factors, such as gene regulation alteration and histone modification . Although therapies such as resection, transplantation and ablation have been widely put into use, the prognosis of HCC patients is still poor because of the high metastasis frequency . Therefore, exploration of potential biomarkers of HCC is urgently needed.…”

Section: Introductionmentioning

confidence: 99%

Hsa_circ_101280 promotes hepatocellular carcinoma by regulating miR‐375/JAK2

Cao

Wang

et al. 2018

Immunol Cell Biol

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In this study, we sought to predict the effects of a certain circular RNA (circRNA), hsa_circ_101280 (also known as hsa_circ_0100929 and hsa_circ_SLAIN1), on hepatocellular carcinoma (HCC) cells and to determine the potential mechanism. After screening differentially expressed circRNAs in HCC tissues through Gene Expression Omnibus data analysis, hsa_circ_101280 was found to be highly expressed, and its high expression was verified in HCC cell lines with qRT‐PCR along with the low expression of its downstream miRNA miR‐375. Colony formation and flow cytometry assays showed that both hsa_circ_101280 silencing and miR‐375 overexpression restrained proliferation and promoted apoptosis in HCC cells. JAK2 was identified as a downstream mRNA target of miR‐375 by RNA pull‐down and dual‐luciferase reporter gene assays, its expression in HCC cell lines were positively regulated by hsa_circ_101280 and negatively by miR‐375 expression. Furthermore, the silencing of hsa_circ_101280 significantly inhibited the growth of HCC xenografts in nude mice, with the downregulated expression of JAK2. Overall, both the in vitro and in vivo studies revealed that hsa_circ_101280 largely facilitated the tumorigenesis of HCC, characterized by the promoted proliferation and suppressed apoptosis of HCC cells, by sponging miR‐375 and upregulating JAK2.

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“…Hepatocellular carcinoma is deemed the fifth most common tumor and the third leading cause for cancer‐related death worldwide . It is estimated that the annual number of newly diagnosed HCC is 21 000, accounting for approximately 700 000 deaths every year .…”

Section: Hepatocellular Carcinoma Metastasismentioning

confidence: 99%

Circular RNAs: Biogenesis, properties, roles, and their relationships with liver diseases

Yao

Chen

et al. 2017

Hepatology Research

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Circular RNAs (circRNAs) are a class of new-found RNA molecules that have a special covalent loop structure without a 5' cap and 3' tail. Researchers have found that circRNAs may be generated by intron-pairing-driven or lariat-driven circularization. They are cleared up by way of extracellular vesicles. They have some advantages such as stability, conservation, and tissue specificity. By serving as sponges of microRNAs, interacting with long non-coding RNAs, mRNA, or proteins, circRNAs regulate gene expression at transcriptional and post-transcriptional levels and contribute to carcinogenesis. In recent years, circRNAs have been found to be correlated with many cancers including hepatocellular carcinoma, one of the most common cancers with high mortality. This article will first introduce the biogenesis, properties, and functions of circRNAs. Then we focus on the molecular mechanisms underlying some circRNAs, including hsa_circ_0001649, hsa_circ_0005075, and cerebellar degeneration-related protein 1 antisense, on hepatocellular carcinoma metastasis.

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Effects of Different Anesthetic Methods on Cellular Immune and Neuroendocrine Functions in Patients With Hepatocellular Carcinoma Before and After Surgery

Cited by 35 publications

References 38 publications

Safety and efficacy of enhanced recovery after surgery (ERAS) programs in patients undergoing hepatectomy: A prospective randomized controlled trial

Safety and efficacy of enhanced recovery after surgery (ERAS) programs in patients undergoing hepatectomy: A prospective randomized controlled trial

Hsa_circ_101280 promotes hepatocellular carcinoma by regulating miR‐375/JAK2

Circular RNAs: Biogenesis, properties, roles, and their relationships with liver diseases

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