Effects of Dietary Zinc Levels on the Activities of Enzymes, Weights of Organs, and the Concentrations of Zinc and Copper in Growing Rats

Sun, Jiazeng; Jing, M.; Weng, Xiao-Yan; Fu, L J; Xu, Zhenghao; Zi, Nai-Tao; Wang, J F

doi:10.1385/bter:107:2:153

Cited by 51 publications

(39 citation statements)

References 41 publications

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“…Yu et al (2010) found that the chelation of zinc by low molecular weight ligands leads to the formation of a soluble complex that can increase Zn absorption. The activity of ALP was greatly increased by Zn addition regardless of sources in this study which is in agreement with other studies (Sun et al 2005;Rocha et al 2015). The Cu-ZnSOD, in which Zn is an integral part, is an important antioxidant defense in nearly all living cells exposed to oxygen (Paz Matias et al 2014).…”

Section: Discussionsupporting

confidence: 94%

Effects of zinc sources and levels on zinc bioavailability, blood parameters, and nutrient balance of male mink (Neovison vison)

Hu¹,

Nie²,

Zhang³

et al. 2018

CZECH J ANIM SCI

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. (2018): Effects of zinc sources and levels on zinc bioavailability, blood parameters, and nutrient balance of male mink (Neovison vison). Czech J. Anim. Sci., 63, 174-181.The objective of this study was to investigate the effects of different sources and levels of zinc (Zn) on nutrient digestibility, plasma metabolites, and relative Zn bioavailability in male mink. Animals in the control group were fed a basal diet, consisting mainly of corn, soybean oil, meat and bone meal, and fish meal, with no Zn supplementation. Mink in the other 9 treatments were fed the basal diet supplemented with Zn from grade Zn sulfate (ZnSO 4 . 7H 2 O), Zn glycinate (ZnGly), or Zn pectin oligosaccharides (ZnPOS) chelate at concentrations of either 100, 300, or 900 mg Zn/kg dry matter. The results showed that zinc levels increased the AD of fat linearly (P < 0.05). The AD of fat in Zn-900 was higher (P < 0.05) than that of the control. Fecal Zn and urinary Zn were affected by dietary Zn addition (P < 0.01). Moreover, Zn supplementation increased Zn retention compared with the control group (P < 0.05). The N retention in ZnPOS was higher (P < 0.05) than that of the control. The effect of Zn level was linear (P < 0.01) for N retention. In addition, the activity of alkaline phosphatase was higher in groups supplemented with 900 mg/kg Zn (P < 0.05) compared with the control group. There were significant interactions (P < 0.05) among Zn sources on the activity of Cu-Zn superoxide dismutase (Cu-ZnSOD). Compared with ZnSO 4 , relative bioavailability values were 148% and 173% for ZnGly and ZnPOS, respectively, based on Cu-ZnSOD activity. In conclusion, our data show that the relative bioavailability of ZnPOS was greater than that of ZnSO 4 . 7H 2 O and ZnGly and Zn supplementation can enhance the Cu-ZnSOD of male mink, and mink can efficiently utilize ZnGly and ZnPOS.Keywords: zinc pectin oligosaccharides chelate; nutrient digestibility; relative bioavailability List of abbreviations: ZnPOS = zinc pectin oligosaccharides chelate, ZnGly = zinc glycinate, DM = dry matter, CP = crude protein, EE = ether extract, AD = apparent digestibility, ALP = alkaline phosphatase, ALB = albumin, ALT = alanine transaminase, TP = total protein, GGT = glutamyl transpeptidase, AST = aspartate aminotransferase, GLU = glucose, Cu-ZnSOD = Cu-Zn superoxide dismutase, GSH-Px = glutathione peroxidase

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Section: Discussionsupporting

confidence: 94%

Effects of zinc sources and levels on zinc bioavailability, blood parameters, and nutrient balance of male mink (Neovison vison)

Hu¹,

Nie²,

Zhang³

et al. 2018

CZECH J ANIM SCI

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“…However, the exact mechanism underlying this regulation remains to be determined. In the present study, food intake was suspected to decrease dramatically in the ZD group, because it has been reported that a zinc-deficient diet causes severe growth retardation and a reduction in food intake (46,47). As the PF group was fed according to the food intake of the ZD group, the intake of the PF group was thought to be severely limited; as a result, the PF group appeared to change its requirements for several minerals and a stress response was triggered.…”

Section: Discussionmentioning

confidence: 71%

Zinc Deficiency Increases Serum Concentrations of Parathyroid Hormone through a Decrease in Serum Calcium and Induces Bone Fragility in Rats

Suzuki

Kajita

Katsumata

et al. 2015

J Nutr Sci Vitaminol

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SummaryWe hypothesized that a zinc-deficient diet alters the mineral (calcium, magnesium, and phosphorus) components of bones, as well as hormones related to bone remodeling, and negatively affects bone metabolism. Four-week-old male Wistar rats were randomly assigned to one of three groups for 4 wk: a zinc-adequate group (C, 30 ppm); a zinc-deficient group (ZD, 1 ppm); and a pair-fed group (PF, 30 ppm), which was pair-fed to the ZD group. Bone mineral density and bone mechanical properties were reduced in the ZD group compared to the C and PF groups. Compared with the C and PF groups, serum osteocalcin, a bone formation marker, was reduced in the ZD group. Conversely, urine deoxypyridinoline, a bone resorption marker, was increased in the ZD group compared to the C and PF groups. Calcium and phosphorus concentrations in bone were not different among all groups. The bone magnesium concentration was significantly higher in the ZD group than in the PF and C groups. Interestingly, compared with the C and PF groups, the ZD group showed a reduction in serum calcium concentration along with an increase in serum parathyroid hormone (PTH) concentration. Although serum 1,25-dihydroxycholecalciferol concentration was significantly higher in the ZD and PF groups than in the C group, the rate of apparent calcium absorption was significantly lower in the ZD group than in the C and PF groups. Therefore, zinc deficiency is suspected to cause an increase in serum PTH concentration owing to an inability to maintain calcium homeostasis, resulting in bone fragility.

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“…These findings indicate that excessive intake of zinc supplements have also potential risk to humans [6]. Reports of the studies examining the zinc effects with different doses on healthy rats are limited and more studies are needed [6,31]. Reseachers observed that zinc deficiency was not only related with the ethanol intake directly but also dependent on the level of the liver damage [3].…”

Section: Discussionmentioning

confidence: 99%

The effect of zinc on ethanol-induced oxidative stress in rat liver

Caglar¹,

Bi̇lgi̇han²,

Turkcu³

et al. 2012

Turk J Bioch

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Aim Zinc is known as an essential trace element and has antioxidant functions. This study was planned to investigate the effects of zinc on oxidative stress induced by ethanol in the rat liver tissue. Methods: Thirty-nine male rats were divided into four groups as control, ethanol (EtOH), zinc (Zn), ethanol plus zinc (EtOH+Zn). The control group (n=10) were injected intraperitoneally (i.p.) with 0.9% saline, EtOH group (n=10) with 2g kg/day ethanol, Zn group (n=10) received orally, ZnSO 4 .7H 2 O at a dose of 7 mg kg/day and EtOH+Zn group (n=9) received zinc (orally) and ethanol (i.p.). On the 13th day, rats were euthanized. Liver tissues were removed and malondialdehyde (MDA), advanced oxidation protein products (AOPP), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione-S-transferase (GST) activities were measured. Tissue zinc levels were determined. Histological analyses of liver tissue specimens were also performed. Results: In EtOH group MDA levels, GPx, SOD activities increased compared with control group. In accordance with histological findings, ethanol induced oxidative stress. But AOPP levels decreased in EtOH group due to supressive effect of ethanol on neutrophil activation and reactive oxygen species (ROS) production. In EtOH+Zn group, MDA, AOPP levels and GPx, SOD activities significantly changed. Besides, histological findings showed that zinc supplementation reduced oxidative stress. But in healthy rats MDA levels increased due to ROS mediated zinc damage. Conclusion: Zinc supplementation was found to offer protection against ethanol-induced liver damage and oxidative stress in rats. However, zinc might increase oxidative stress in healthy rats. Key Words: Ethanol, zinc; oxidative stress, antioxidant, liver Conflict of interest: Authors did not declare any conflict of interest. ÖZETAmaç: Çinko antioksidan etkileri olan esansiyel bir eser elementtir. Bu çalışma, rat karaciğerinde etanolle indüklenen oksidatif strese çinkonun etkilerini incelemek amacıyla planlanmıştır. Gereç ve Yöntemler: Otuz dokuz erkek rat 4 gruba ayrılmıştır. Kontrol, etanol (EtOH), çinko (Zn), etanol ve çinko (EtOH+Zn). Kontrol grubuna (n=10) intraperitonel (i.p.) % 0.9 tuz çözeltisi, EtOH grubuna (n=10) 2g/kg/gün etanol, Zn grubuna (n=10) oral olarak 7 mg/ kg/gün ZnSO 4 .7H 2 O ve ETOH+Zn grubuna (n=9) oral olarak çinko ve i.p. ethanol verilmiştir. Onüçüncü gün ratlar feda edilmiştir. Karaciğer dokuları çıkarılarak malondialdehit (MDA), ileri okside protein ürünleri (AOPP) düzeyleri, süperoksit dismutaz (SOD), glutatyon peroksidaz (GPx), glutatyon redüktaz (GR), ve glutatyon-S-transferaz (GST) aktiviteleri ve doku çinko düzeyleri ölçülmüştür.Karaciğer dokularının histolojik incelemeleri gerçekleştirilmiştir. Bulgular: Etanol grubunda hepatik MDA düzeyleri, GPx, SOD aktiviteleri kontrol grubuna göre artmıştır ve histolojik bulguların da desteklediği gibi etanolün oksidatif stresi artırdığını göstermektedir.Ancak EtOH grubundaki AOPP düzeylerindeki düşüş, etanolün nötro...

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Effects of Dietary Zinc Levels on the Activities of Enzymes, Weights of Organs, and the Concentrations of Zinc and Copper in Growing Rats

Cited by 51 publications

References 41 publications

Effects of zinc sources and levels on zinc bioavailability, blood parameters, and nutrient balance of male mink (Neovison vison)

Effects of zinc sources and levels on zinc bioavailability, blood parameters, and nutrient balance of male mink (Neovison vison)

Zinc Deficiency Increases Serum Concentrations of Parathyroid Hormone through a Decrease in Serum Calcium and Induces Bone Fragility in Rats

The effect of zinc on ethanol-induced oxidative stress in rat liver

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